个人简介

Ph.D., Concordia University (Montreal), 1983

研究领域

Physical Chemistry Chemical Biology Center for Structural Biology Biophysical Chemistry Biochemistry

Research in our laboratory seeks to characterize the structure and motions of proteins and nucleic acids, and the way in which they interact with other proteins, nucleic acids and drugs. We are in essence using the power of the chemistry approach to address key problems in biology and medicine. NMR spectroscopy is the primary experimental tool, though in studying these complex biomolecules, we make use of other biophysical and structural techniques, including X-ray crystallography, calorimetry, fluorescence spectroscopy and X-ray scattering.

近期论文

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Vaithiyalingam S., Arnett D.R., Aggarwal A., Eichman B.F., Fanning E., Chazin W.J. Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase. Journal of Molecular Biology. 2014, 426 (3): 558-69. Frank A.O., Vangamudi B., Feldkamp M.D., Souza-Fagundes E.M., Luzwick J.W., Cortez D., Olejniczak E.T., Waterson A.G., Rossanese O.W., Chazin W.J., Fesik S.W. Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A. Journal of Medicinal Chemistry. 2014, 0 (0): [Epub ahead of print]. Hwang H.S., Nitu F.R., Yang Y., Walweel K., Pereira L., Johnson C.N., Faggioni M., Chazin W.J., Laver D.R., George A. Jr., Cornea R.L., Bers D.M., Knollmann B.C. Divergent Regulation of RyR2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants. Circulation Research. 2014, 0 (0): [Epub ahead of print]. Soss S.E., Klevit R.E., Chazin W.J. Activation of UbcH5c similar to Ub Is the Result of a Shift in Interdomain Motions of the Conjugate Bound to U-Box E3 Ligase E4B. Biochemistry. 2013, 52 (17): 2991-2999. Damo S.M., Kehl-Fie T.E., Sugitani N., Holt M.E., Rathi S., Murphy W.J., Zhang Y.F., Betz C., Hench L., Fritz G., Skaar E.P., Chazin W.J. Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 2013, 110 (10): 3841-3846. Brosey C.A., Yan C.L., Tsutakawa S.E., Heller W.T., Rambo R.P., Tainer J.A., Ivanov I., Chazin W.J. A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Research. 2013, 41 (4): 2313-2327. Damo S., Chazin W.J., Skaar E.P., Kehl-Fie T.E. Inhibition of bacterial superoxide defense A new front in the struggle between host and pathogen. Virulence. 2012, 3 (3): 325-328. Pruneda J.N., Littlefield P.J., Soss S.E., Nordquist K.A., Chazin W.J., Brzovic P.S., Klevit R.E. Structure of an E3:E2 similar to Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases. Molecular Cell. 2012, 47 (6): 933-942. Shell S.M., Chazin W.J. XPF-ERCC1: On the Bubble. Structure. 2012, 20 (4): 566-568. Liu J.Z., Jellbauer S., Poe A.J., Ton V., Pesciaroli M., Kehl-Fie T.E., Restrepo N.A., Hosking M.P., Edwards R.A., Battistoni A., Pasquali P., Lane T.E., Chazin W.J., Vogl T., Roth J., Skaar E.P., Raffatellu M. Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut. Cell Host & Microbe. 2012, 11 (3): 227-239. Souza-Fagundes E.M., Frank A.O., Feldkamp M.D., Dorset D.C. Chazin W.J., Rossanese O.W., Olejniczak E.T., Fesik S.W. A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A. Analytical Biochemistry. 2012, 421 (2): 742-749. Guler G.D., Liu H.J., Vaithiyalingam S., Arnett D.R., Kremmer E., Chazin W.J., Fanning E. Human DNA Helicase B (HDHB) Binds to Replication Protein A and Facilitates Cellular Recovery from Replication Stress. Journal of Biological Chemistry. 2012, 287 (9): 6469-6481. Williams C.K., Vaithiyalingam S., Hammel M., Pipas J., Chazin W.J. Binding to retinoblastoma pocket domain does not alter the inter-domain flexibility of the J domain of SV40 large T antigen. Archives of Biochemistry and Biophysics. 2012, 518 (2): 111-118. Kehl-Fie T.E., Chitayat S., Hood M.I., Damo S., Restrepo N., Garcia C., Munro K.A., Chazin W.J., Skaar E.P. Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus. Cell Host & Microbe. 2011, 10 (2): 158-164. Liu Y., Vaithiyalingam S., Shi Q., Chazin W.J., Zinkel S.S. BID Binds to Replication Protein A and Stimulates ATR Function following Replicative Stress. Molecular and Cellular Biology. 2011, 31 (21): 4298-4309. Chagot B., Chazin W.J. Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5. Journal of Molecular Biology. 2011, 406 (1): 106-119. Soss S.E., Yue Y.Y., Dhe-Paganon S., Chazin W.J. E2 Conjugating Enzyme Selectivity and Requirements for Function of the E3 Ubiquitin Ligase CHIP. Journal of Biological Chemistry 2011, 286 (24): 2177-21286. Chazin W.J. Relating Form and Function of EF-Hand Calcium Binding Proteins. Acc Chem Res. 2011, 44 (3): 171-179. Nordquist K.A., Dimitrova Y.N., Brzovic P.S., Ridenour W.B., Munro K.A., Soss S.E., Caprioli R.M., Klevit R.E., Chazin W.J. Structural and Functional Characterization of the Monomeric U-Box Domain from E4B. Biochemistry. 2010, 49 (2): 347-355.