个人简介
教育背景
1999年1月— 2002年1月: 在新加坡国立大学化学与环境工程系攻读博士学位，并于2002年10月获工学博士学位
1995年9月—1998年7月: 在清华大学核能技术研究院学习，获工学硕士学位
1990年9月—1995年7月: 在清华大学化学工程系学习，获工学学士学位
工作经历
1998年7月—1998年12月：清华紫光英力公司，研发工程师
2002年2月— 2005年1月：新加坡国立大学化学及过程工程中心，博士后研究员
2005年2月—2007年6月：新加坡南洋理工大学化学与生物分子工程系，博士后研究员。其间2005年9月—2006年3月，在美国加州理工学院作博士后, 进行酶的定向进化研究
2007年7月—：浙江大学化学工程与生物工程学院，教授，博导
研究领域
酶定向进化及理性设计
酶催化手性药物拆分及合成的研究
代谢工程与合成生物学
近期论文
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Shen Bin, Zhou Pingping, Jiao Xue, Yao Zhen, Ye Lidan, Yu Hongwei, Fermentative production of Vitamin E tocotrienols in Saccharomyces cerevisiae under cold-shock-triggered temperature control, Nature Communications 11,5155,2020.
Yang XH, et al.,Engineering of Decameric D-fructose-6-phosphate Aldolase A by Combinatorial Modulation of Inter- and Intra-subunit Interactions, Chemical Communications, 2020.
Zhang, YY ; Wang, J ; Cao, XS ; Liu, W ; Yu, HW ; Ye, LDHigh-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm ENZYME AND MICROBIAL TECHNOLOGY 134, 109462, 2020
Su Bingmei et al.,Rational Design of Dehydrogenase Reductases Based on Comparative Structural Analysis of Prereaction-State and Free-State Simulations for Efficient Asymmetric Reduction of Bulky Aryl Ketones, ACS CATALYSIS 卷: 10 期: 1 页: 864-876 出版年: JAN 3 2020
Naeem, Muhammad; Li, Aipeng;Asymmetric Bioreduction of 4-hydroxy-2-butanone by Carbonyl Reductases PFODH and CpSADH Delivers 1,3-butanediol Enantiomers with Excellent R- and S-enantioselectivity. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 卷: 24 期: 6 页: 972-980 出版年: DEC 2019
Wu, XF ; Yang, SL ; Yu, HW ; Ye, LD; Su, BM ; Shao, ZH, Improved enantioselectivity of E. coli BioH in kinetic resolution of methyl (S)-3-cyclohexene-1-carboxylate by combinatorial modulation of steric and aromatic interactions BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 卷: 83 期: 7 页: 1263-1269 出版年: JUL 3 2019
Wang, WY ; Su, SS ; Wang, SZ ; Ye, LD ; Yu, HW Significantly improved catalytic efficiency of caffeic acid O-methyltransferase towards N-acetylserotonin by strengthening its interactions with the unnatural substrate's terminal structure. ENZYME AND MICROBIAL TECHNOLOGY 卷: 125 页: 1-5 出版年: JUN 2019
Pingping Zhou, Min Li, Bin Shen, Zhen Yao, Qi Bian, Lidan Ye*, and Hongwei Yu, Directed co-evolution of #-carotene ketolase and hydroxylase and its application in temperature-regulated biosynthesis of astaxanthin. Journal of agriculture and food chemistry.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 卷: 67 期: 4 页: 1072-1080 出版年: JAN 30 2019
Semi-rational engineering of carbonyl reductase YueD for efficient biosynthesis of halogenated alcohols with in situ cofactor regeneration Author(s): Naeem, Muhammad; Rehman, Ashfaq Ur; Shen, Bin; et al. Source: BIOCHEMICAL ENGINEERING JOURNAL Volume: 137 Pages: 62-70 Published: SEP 15 2018
Enhanced Isoprene Production by Reconstruction of Metabolic Balance between Strengthened Precursor Supply and Improved Isoprene Synthase in Saccharomyces cerevisiae Author(s): Yao, Zhen; Zhou, Pingping; Su, Bingmei; et al. Source: Acs Synthetic Biology Volume: 7 Issue: 9 Pages: 2308-2316 Published: SEP 2018
From molecular engineering to process engineering: development of high-throughput screening methods in enzyme directed evolution Author(s): Ye, Lidan; Yang, Chengcheng; Yu, Hongwei Source: Applied Microbiology and Biotechnology Volume: 102 Issue: 2 Pages: 559-567 Published: JAN 2018
Development of a temperature-responsive yeast cell factory using engineered Gal4 as a protein switch Author(s): Zhou, Pingping; Xie, Wenping; Yao, Zhen; et al. Source: Biotechnology and Bioengineering Volume: 115 Issue: 5 Pages: 1321-1330 Published: MAY 2018
Zhu Yongqiang et al., Yu Hongwei*, Enhanced synthesis of Coenzyme Q10 by reducing the competitive production of carotenoids in Rhodobacter sphaeroides, Biochemical Engineering Journal, Volume: 125 Pages: 50-55 Published: SEP 15 2017.
Zhu Yongqiang et al., Yu Hongwei*, Synergic Regulation of Redox Potential and Oxygen Uptake to Enhance Production of Coenzyme Q10 in Rhodobacter sphaeroides, Enzyme and Microbial Technology Volume: 101 Pages: 36-43 Published: JUN 2017.
Zhou Pingping et al., Ye Lidan*, Yu Hongwei, Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae, Enzyme and Microbial Technology Volume: 100 Pages: 28-36 Published: MAY 2017.
Wang Fan, et al., Ye Lidan*, Yu Hongwei*, Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae, Metabolic Engineering, Volume: 39 Pages: 257-266 Published: JAN 2017.
Yang Xiaohong, et al., Yu Hongwei* Engineering of D-Fructose-6-Phosphate Aldolase A for Improved Activity towards Cinnamaldehyde, Catalysis Science & Technology, Volume: 7 Issue: 2 Pages: 382-386 Published: 2017.
Lv Xiaomei, et al., Yu Hongwei*, Assembly of Biosynthetic Pathways in Saccharomyces cerevisiae Using A Ready-to-use Marker Recyclable Integrative Plasmid Toolbox, Frontiers of Chemical Science and Engineering, Volume: 11 Issue: 1 Pages: 126-132 Published: MAR 2017.
Yang ChengCheng, et al., Yu Hongwei*, Directed evolution of mandelate racemase by a novel high-throughput screening method, Applied Microbiology and Biotechnology, Volume: 101 Issue: 3 Pages: 1063-1072 Published: FEB 2017.
Xiaomei Lv, Fan Wang, Pingping Zhou, Lidan Ye, Wenping Xie, Haoming Xu & Hongwei Yu* Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae, Nature Communications, Volume: 7 Published: SEP 2016.
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