Guo, Deliang - The Ohio State University - Molecular, Cellular and Developmental Biology

个人简介

I am an associate professor in the Department of Radiation Oncology at The Ohio State University and a member of the Translational Therapeutics Program at the OSUCCC – James, where my work is focused on determining the key molecular targets in cancer metabolism and translating those findings into the clinical setting. I am the co-holder of a patent on a novel strategy for targeting EGFR-activated glioblastoma, the most lethal form of brain cancer. My recent research includes work that first identifies that lipid droplets are unique organelles enriched in glioblastoma patient tumor tissues and suggests a novel therapeutic strategy to treat this disease by interrupting lipid-droplet metabolism. I have also been part of research targeting SREBP-1-driven lipid metabolism to treat cancer. I have co-authored a dozen articles in prestigious publications, such as Neuro-Oncology, Current Pharmaceutical Design, Clinical Cancer Research and Journal of Translational Medicine. He has also made presentations to various organizations, including the American Heart Association and American Association for Cancer Research.

研究领域

Glioblastoma Neoplasms Glioma Brain Neoplasms Melanoma

近期论文

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May 07, 2019 oHSV therapy increases trametinib access to brain tumors and sensitizes them in vivo.Yoo JY, Swanner J, Otani Y, Nair M, Park F, Banasavadi-Siddegowda Y, Liu J, Jaime-Ramirez AC, Hong B, Geng F, Guo D, Bystry D, Pelphs M, Quadri H, Lee TJ, Kaur B May 01, 2019 Longitudinal multi-omics of host-microbe dynamics in prediabetes.Wenyu Zhou W, M Reza Sailani MR, Kévin Contrepois K, Yanjiao Zhou Y, Sara Ahadi S, Shana R Leopold SR, Martin J Zhang MJ, Varsha Rao V, Monika Avina M, Tejaswini Mishra T, Jethro Johnson J, Brittany Lee-McMullen B, Songjie Chen S, Ahmed A Metwally AA, Thi Dong Binh Tran TDB, Hoan Nguyen H, Xin Zhou X, Brandon Albright B, Bo-Young Hong BY, Lauren Petersen L, Eddy Bautista E, Blake Hanson B, Lei Chen L, Daniel Spakowicz D, Amir Bahmani A, Denis Salins D, Benjamin Leopold B, Melanie Ashland M, Orit Dagan-Rosenfeld O, Shannon Rego S, Patricia Limcaoco P, Elizabeth Colbert E, Candice Allister C, Dalia Perelman D, Colleen Craig C, Eric Wei E, Hassan Chaib H, Daniel Hornburg D, Jessilyn Dunn J, Liang Liang L, Sophia Miryam Schüssler-Fiorenza Rose SMS, Kim Kukurba K, Brian Piening B, Hannes Rost H, David Tse D, Tracey McLaughlin T, Erica Sodergren E, George M Weinstock GM, Michael Snyder M January 21, 2018 Lipid metabolism reprogramming and its potential targets in cancer.Cheng C, Geng F, Cheng X, Guo D January 01, 2018 SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy.Cheng X, Li J, Guo D May 01, 2017 Lipid droplets, potential biomarker and metabolic target in glioblastoma.Geng F, Guo D January 24, 2017 Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.Ru P, Hu P, Geng F, Mo X, Cheng C, Yoo JY, Cheng X, Wu X, Guo JY, Nakano I, Lefai E, Kaur B, Chakravarti A, Guo D January 01, 2017 microRNA-29 mediates a novel negative feedback loop to regulate SCAP/SREBP-1 and lipid metabolism.Ru P, Guo D November 01, 2016 Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.Geng F, Cheng X, Wu X, Yoo JY, Cheng C, Guo JY, Mo X, Ru P, Hurwitz B, Kim SH, Otero J, Puduvalli V, Lefai E, Ma J, Nakano I, Horbinski C, Kaur B, Chakravarti A, Guo D January 09, 2016 Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.Ru P, Hu P, Geng F, Mo X, Cheng C, Yoo JY, Cheng X, Wu X, Guo JY, Nakano I, Lefai E, Kaur B, Chakravarti A, Guo D November 09, 2015 Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, Cheng X, Euthine V, Hu P, Guo JY, Lefai E, Kaur B, Nohturfft A, Ma J, Chakravarti A, Guo D