Guo, Peixuan - The Ohio State University - Center for RNA Nanobiotechnology and Nanomedicine

个人简介

Dr. Peixuan Guo received his Ph.D. in Microbiology and Genetics with training in biophysics from the University of Minnesota in 1987. He was a postdoc at NIH before joining Purdue University as an assistant professor in 1990, tenured in 1993, full Professor in 1997, and was honored as a Purdue Faculty Scholar in 1998. He founded two Interdisciplinary Graduate Programs and established a NIH Nanomedicine Development Center at Purdue. He was recruited to University of Cincinnati as the Dane & Mary Louise Miller Endowed Chair of Biomedical Engineering in 2007, and was Director of the NIH Nanomedicine Development Center relocated from Purdue to University of Cincinnati. He moved to University of Kentucky as William Farish Endowed Chair in Nanobiotechnology in 2012, and was the UK Director of Nanobiotechnology Center. In Jan 2016, he joined The Ohio State University College of Pharmacyas the first Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery Systems. He was recruited in collaboration with Ohio State’s Dorothy M. Davis Heart and Lung Research Institute (DHLRI) and will hold a joint appointment in the College of Medicine’s Department of Physiology & Cell Biology. He is also currently the Director of NCI Cancer Nanotechnology Platform Partnership Program in RNA Nanotechnology for Cancer Therapy, and the Director of Center for RNA Nanobiotechnology and Nanomedicine.

研究领域

Nanobiotechnology, including structure, function and applications of phi29 DNA-packaging nanomotor. RNA Nanotechnology and siRNA/drug delivery. Single molecule imaging and optical instrumentation to study the nanomotor and RNA nanoparticles. Single pore sensing and singe pore DNA sequencing using the connector of phi29 DNA packaging motor.

近期论文

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Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P. RNA Nanoparticles as Rubber for Complelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity. ACS Nano. 2020 Sep. Accepted.[link][PDF] Xu C, Zhang K, Yin H, Li Z, Krasnoslobodtsev A, Zheng Z, Ji Z, Guo S, Li S, Chiu W, Guo P. 3D RNA Nanocage for Encapsulation and Shielding of Hydrophobic Biomolecules to Improve the in vivo Biodistribution. Nano Research. 2020 Jul.[link][PDF] Li X, Vieweger M, Guo P. Self-assembly of four generations of RNA dendrimers for drug shielding with controllable layer-by-layer release. Nanoscale. 2020 Jul; 16514-16525.[link][PDF] Liang C, Tao W, Zhou L, Guo P. Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine. 2020 Jun.[link][PDF] Tao W, Zhou L, Li Z, Zhang L, Guo P. Nanotechnology application of bacteriophage DNA packaging nanomotors in single pore sensing of DNA, RNA, chemicals, and proteins. Reference Module in Life Sciences. 2020.[link][PDF] Guo P. High resolution structure of hexameric herpesvirus DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent debate. PROTEIN CELL. 2020 Apr.[link][PDF] Guo S, Vieweger M, Zhang K, Yin H, Wang H, Li X, Li S, Hu S, Sparreboom A, Evers M, Dong Y, Chiu W, Guo P. Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy. Nature Communications. 2020 Feb; 972.[link][PDF] Ji Z, Jordan M, Jayasinghe L, Guo P. Insertion of channel of phi29 DNA packaging motor into polymer membrane for high-throughput sensing. Nanomedicine: NBM. 2020 Feb; 102170.[link][PDF] Lee T, Mohammadniaei M, Zhang H, Yoon J, Choi H, Guo S, Guo P, Choi J. Single Functionalized pRNA/Gold Nanoparticle for Ultrasensitive MicroRNA Detection Using Electrochemical Surface-Enhanced Raman Spectroscopy. Adv. Sci. 2020 Feb;1902477.[link][PDF] Piao X, Yin H, Guo S, Wang H, Guo P. RNA Nanotechnology to Solubilize Hydrophobic Antitumor Drug for Targeted Delivery. Adv. Sci. 2019 Sep;1900951.[link][PDF] Guo S, Xu C, Yin H, Hill J, Pi F, Guo P. Tuning the size and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation. WIREs Nanomed Nanobiotechnol. 2019 Aug;311-312:43-49.[link][PDF] Li H, Wang S, Ji Z, Xu C, Shlyakhtenko, Guo P. Construction of RNA nanotubes. Nano Research. 2019 Aug;1952-1958.[link][PDF] Zheng Z, Li Z, Xu C, Guo B, Guo P. Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping. J Control Release. 2019 Oct;311-312:43-49.[link][PDF] Ji Z, Guo P. Channel from bacterial virus T7 DNA packaging motor for the differentiation of peptides composed of a mixture of acidic and basic amino acids. Biomaterials. 2019 May 21;214:119222.[link][PDF] Guo P, Driver D, Zhao Z, Zheng Z, Chan C, Cheng X. Controlling the Revolving and Rotating Motion Direction of Asymmetric Hexameric Nanomotor by Arginine Finger and Channel Chirality. ACS Nano. 2019 May 8;13(6):6207-6223.[link][PDF] Das S, Extracellular RNA Communication Consortium, et al. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 Apr 4;177(2):231-242.[link][PDF] Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D. Delivery of Anti-miRNA for Triple Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting to Stem Cell Marker CD133. Molecular Therapy. 2019 Jul 03;27(7):1252-1261.[link][PDF] Jasinski DL, Binzel DW, Guo P. One-Pot Production of RNA Nanoparticles via Automated Processing and Self-Assembly. ACS Nano. 2019 Apr 23;13(4):4603-4612.[link][PDF] Yin H, Wang H, Li Z, Shu D, Guo P. RNA Micelles for Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand. ACS Nano. 2019 Jan 22;13(1):706-717.[link][PDF] Xu C, Li H, Zhang K, Binzel D, Yin H, Chiu W, Guo P. Photo-controlled release of paclitaxel and model drugs from RNA pyramids. Nano Research. 2019;12: 41.[link][PDF]