陈浩 - 中国科学院上海药物研究所 -

个人简介

教育经历 2005. 9-2009. 6，武汉大学，药学，理学学士 2014. 2-2015. 6，斯坦福大学，分子影像中心，联合培养博士 2009 .9-2015. 6，武汉大学，生物化学与分子生物学（药物化学方向），理学博士工作经历 2015. 6-2019. 2 斯坦福大学，分子影像中心，博士后 2019. 2-至今中国科学院上海药物研究所，研究员，课题组长

研究领域

1. 有机小分子诊疗药物研发 (荧光，PET-CT/SPECT-CT等，药物化学) 2. 分子影像技术在药物开发中的应用研究（药理学） 3. 短波红外或近红外二区新型成像系统，软件算法开发（仪器设备）

近期论文

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A. Ji#, H. Lou#, C. Qu, W. Lu, Y. Hao, J. Li, Y. Wu, T. Chang, H. Chen*, Z. Cheng*. Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance. Nature Communications, 2022 (accepted) H. Chen#, L. Liu#, K. Qian, H. Liu, Z. Wang, F. Gao, C. Qu, W. Dai, D. Lin, K. Chen, H. Liu*, Z. Cheng*. Bioinspired Large Stokes Shift Small Molecular Dyes for Biomedical Fluorescent Imaging. Science Advances, 2022 (accepted) Q. Qiu, T. Chang, Y. Wu, C. Qu*, H. Chen*, Z. Chen*. Liver injury long-term monitoring and fluorescent image-guided tumor surgery using self-assembly amphiphilic donor-acceptor NIR-II dye. Biosensors and Bioelectronics, 2022. doi: https://doi.org/10.1016/j.bios.2022.114371 L. Zheng#, Z. Wang#, X. Zhang, Y. Zhou, A. Ji, H. Lou, X. Liu*, H. Chen*, Z. Cheng*. Development of Mitochondria-Targeted Small-Molecule Dyes for Myocardial PET and Fluorescence Bimodal Imaging. Journal of Medicinal Chemistry, 2022, 65(1), 497-506. (封面文章) Y. Li#, H. Zhou#, R. Bi, X. Li, Y. Yang, J. Ni, W. H. Liew, M. Olivo, K. Yao, J. Liu*, H. Chen*, K. Li*. Acceptor Engineering of Small Molecule Fluorophores for NIR-II Fluorescent and Photoacoustic Imaging. Journal of Materials Chemistry B, 2021, 9 (48), 9951-9960. X. Zhang#, A. Ji#, Z. Wang, H. Lou, J. Li, L. Zheng, Y. Zhou, C. Qu*, X. Liu*, H. Chen*, Z. Cheng*. Azide-dye unexpected bone targeting for near-infrared window II osteoporosis imaging. Journal of Medicinal Chemistry, 2021, 64, 11543-11553. (封面文章) H. Chen#, H. Yang#, C. Zhang, S. Chen, X. Zhao, M. Zhu, Z. Wang, Y. Wang, H. T. Wo, K. Li*, Z. Cheng*. Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker. Research, 2021, 9798580. H. Chen, K. Shou, S. Chen, C. Qu, Z. Wang, L. Jiang, M. Zhu, B. Ding, K. Qian, A. Ji, H. Lou, L. Tong, A. Hsu, Y. Wang, D. W. Felsher, Z. Hu*, J. Tian*, Z. Cheng*. Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging. Advanced Materials, 2021, 2006902. （封面文章） Y. Yang, X. Fan, L. Li, Y. Yang, A. Nuernisha, D. Xue, C. He, J. Qian*, Q. Hu*, H. Chen*, J. Liu*, W. Huang. Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence. ACS Nano, 2020, 14 (2), 2509–2521. （高被引文章） H. Chen#, J. Wang#, X. Feng, H, M. Zhu, S. Hoffmann, A. Hsu, K. Qian, D. Huang, F. Zhao, W. Liu, H. Zhang*, Z. Cheng*. Mitochondria-targeted fluorescent molecules for high efficiency cancer growth inhibition and imaging. Chemical Science, 2019, 10, 7946-7951.