齐建勋 - 中国科学院微生物研究所 -

个人简介

2004-2008 中国科学院物理研究所凝聚态物理专业博士 2008-2011 中国科学院微生物研究所病原微生物与免疫学重点实验室,助理研究员 2011-2018 中国科学院微生物研究所病原微生物与免疫学重点实验室,副研究员 2018-今中国科学院微生物研究所病原微生物与免疫学重点实验室,研究员,研究组长

研究领域

1.采用X-ray，Cryo-EM以及SAXS等结构生物学手段，解析病原微生物入侵宿主细胞的分子机制，把不同层面、不同尺度的结构信息整合起来，并结合生化功能，解析病原微生物侵入宿主的分子机制 2.基于病原优势表位设计纳米颗粒亚单位疫苗（nano-paiticle vaccine），不仅使优势抗原表位有效暴露在纳米颗粒的表面，而且组装成多重拷贝、结构稳定的纳米颗粒疫苗来预防病原微生物的侵入 3.基于已有抗原优势表位信息设计1010数量级的特异性抗体，筛选排名靠前的抗体，并在分子水平，细胞水平和动物水平来评估抗体的保护效果；把不同表位抗体组合成鸡尾酒，高效阻断病原微生物的生命周期 4.基于病原生命周期中关键酶设计小分子抑制剂，基于小分子和靶蛋白原子层面的互作机制来优化小分子抑制剂，提高其亲和力和特异性以及药代动力学水平，进而开发成高效阻断病原的抑制剂

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Qihui Wang, Yanfang Zhang, Lili Wu, Sheng Niu, Chunli Song, Zengyuan Zhang, Guangwen Lu, Chengpeng Qiao, Yu Hu, Kwok-Yung Yuen, Qisheng Wang, Huan Zhou, Jinghua Yan and Jianxun Qi, Structural and functional basis of COVID-19 virus entry by using human ACE2; Cell, 2020,181:894-04 (入选Faulty of 1000). Ruili Liu, Yeping Sun,Yan Chai, Su Li, Shihua Li, Liang Wang, Jiaqi Su, Shaoxiong Yu, Jinghua Yan, Feng Gao, Gaiping Zhang, Hua-Ji Qiu, George F. Gao#, Jianxun Qi#, and Han Wang#, The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives; PNAS, 2020,117: 11000-11009. Fanli Yang*,Sheng Lin*, Fei Ye*, Jing Yang*， Jianxun Qi*, Zhujun Chen, Xi Lin, Jichao Wang, Dan Yue, Yanwei Cheng, Zimin Chen, Hua Chen, Yu You, Zhonglin Zhang, Yu Yang, Ming Yang, Honglu Sun, Yuhua Li, Yu Cao, Shengyong Yang, Yuquan Wei, George F. Gao, and Guangwen Lu，Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody，Cell Host & Microbe, 2020, 27:441-453. Ruchao Peng, Shuijun Zhanga, Yingzi Cui, Yi Shi, George F. Gao#, and Jianxun Qi#, Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus; PNAS, 2017,114: E8905-E8912. Shuguang Tan, Kefang Liu, Yan Chai, Catherine W.-H. Zhang, Shan Gao, George F. Gao, Jianxun Qi#, Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab, Protein & Cell, 2018, 9：135-139 Han Wang*, Yi Shi*, Jian Song*, Jianxun Qi*, Guangwen Lu, Jinghua Yan, George F. Gao, Ebola viral glycoprotein bound to its endosomal receptor Niemann-Pick C1, Cell, 2016,164: 258-268. Ying Wu, Christopher J Vavricka, Yan Wu, Qing Li, Santosh Rudrawar, Robin J. Thomson,Mark von Itzstein, George F. Gao and Jianxun Qi#, Atypical group1 neuraminidase pH1N1-N1 bound to a group1 inhibitor, Protein & Cell, 2015, 6: 771-773 Guangwen Lu*, Yawei Hu*, Qihui Wang*, Jianxun Qi*, Feng Gao*, Yan Li, Yanfang Zhang, Wei Zhang, Yuan Yuan, Jinku Bao, Buchang Zhang, Yi Shi, Jinghua Yan & George F. Gao，Molecular basis of binding between novel human coronavirus MERS-CoVand its receptor CD26, Nature, 2013, 500: 227-232