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个人简介

学习经历 1981年-1985年,南京大学,获得生物化学学士学位。 1985年-1988年,中国科学院微生物研究所,获得生物化学及酶学硕士学位。 1991年-1995年,美国的Rutgers大学,获得生物化学及分子生物学博士学位。 工作经历 1988年至1991年:中国科学院微生物研究所,助理研究员。 1995年至1997年:美国洛克菲勒大学,博士后。 1997年至2008年:美国杜邦农业化学公司,生物化学研究员、资深生物化学研究员。 2008年至2010年:美国杜邦公司研发中心,资深研究员。 2010年至今:中国科学院微生物研究所,研究员,博士生导师。工业微生物与生物技术研究室主任

研究领域

以代谢工程为基础的新型生物催化剂开发与利用

近期论文

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Zhang Y, Zhou H, Tao Y, Lin B (2020) Reconstitution of the ornithine cycle with arginine:glycine amidinotransferase to engineer Escherichia coli into an efficient whole-cell catalyst of guanidinoacetate. ACS synthetic biology 2020, doi:10.1021/acssynbio.0c00138 Feng J, Li R, Zhang S, Bu Y, Chen Y, Cui Y, Lin B, Chen Y, Tao Y, Wu B, Bioretrosynthesis of FunctionalizedN-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes. Advanced Science 2020, 2001188. Gao Q, Chen H, Wang W, Huang J, Tao Y, Lin B (2020) Menaquinone-7 production in engineered Escherichia coli. World journal of microbiology & biotechnology 2020, 36(9):132-132. Wang L, Piao X, Cui S, Hui M, Tao Y (2020) Enhanced production of beta-alanine through co-expressing two different subtypes ofl-aspartate-alpha-decarboxylase. Journal of Industrial Microbiology & Biotechnology 2020, 47(6-7):465-474. Zhu, J.; Yang, W.; Wang, B.; Liu, Q.; Zhong, X.; Gao, Q.; Liu, J.; Huang, J.; Lin, B.; Tao, Y., Metabolic engineering of Escherichia coli for efficient production of L-alanyl-L-glutamine. Microb Cell Fact 2020, 19 (1): 129. You, R.; Wang, L.; Shi, C.; Chen, H.; Zhang, S.; Hu, M.; Tao, Y., Efficient production of myo-inositol in Escherichia coli through metabolic engineering. Microb Cell Fact 2020, 19 (1): 109. Yao, J.; Li, J.; Xiong, D.; Qiu, Y.; Shi, G.; Jin, J. M.; Tao, Y.; Tang, S. Y., Development of a highly efficient and specific L-theanine synthase. Appl Microbiol Biotechnol 2020, 104 (8): 3417-3431. Yao, J.; He, Y.; Su, N.; Bharath, S. R.; Tao, Y.; Jin, J. M.; Chen, W.; Song, H.; Tang, S. Y., Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps. Nat Commun 2020, 11 (1): 1515. Xu, X.; Zhong, H.; Liu, W.; Tao, Y., Extension of Genetic Marker List Using Unnatural Amino Acid System: An Efficient Genomic Modification Strategy in Escherichia coli. Front Bioeng Biotechnol 2020, 8: 145. Wang, L.; Song, L.; He, X.; Teng, F.; Hu, M.; Tao, Y., Production of isofloridoside from galactose and glycerol using α-galactosidase from Alicyclobacillus hesperidum. Enzyme Microb Technol 2020, 134: 109480. Wang, L.; Piao, X.; Cui, S.; Hu, M.; Tao, Y., Enhanced production of β-alanine through co-expressing two different subtypes of L-aspartate-α-decarboxylase. J Ind Microbiol Biotechnol 2020. Ma, C.; Mu, Q.; Wang, L.; Shi, Y.; Zhu, L.; Zhang, S.; Xue, Y.; Tao, Y.; Ma, Y.; Yu, B., Bio-production of high-purity propionate by engineering L-threonine degradation pathway in Pseudomonas putida. Appl Microbiol Biotechnol 2020, 104 (12): 5303-5313. Zhang, S.; Yang, W.; Chen, H.; Liu, B.; Lin, B.; Tao, Y., Metabolic engineering for efficient supply of acetyl-CoA from different carbon sources in Escherichia coli. Microb Cell Fact 2019, 18 (1): 130. Wang, T.; Teng, K.; Liu, Y.; Shi, W.; Zhang, J.; Dong, E.; Zhang, X.; Tao, Y.; Zhong, J., Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets. Front Microbiol 2019, 10: 90. Wang, J.; Zhao, H.; Zhao, G.; Chen, D.; Tao, Y.; Wu, S., Enhancing the atypical esterase promiscuity of the γ-lactamase Sspg from Sulfolobus solfataricus by substrate screening. Appl Microbiol Biotechnol 2019, 103 (10): 4077-4087. Teng, F.; You, R.; Hu, M.; Liu, W.; Wang, L.; Tao, Y., Production of d-glucuronic acid from myo-inositol using Escherichia coli whole-cell biocatalyst overexpressing a novel myo-inositol oxygenase from Thermothelomyces thermophile. Enzyme Microb Technol 2019, 127: 70-74. Piao, X.; Wang, L.; Lin, B.; Chen, H.; Liu, W.; Tao, Y., Metabolic engineering of Escherichia coli for production of L-aspartate and its derivative β-alanine with high stoichiometric yield. Metab Eng 2019, 54: 244-254. Mu, Q.; Cui, Y.; Tian, Y.; Hu, M.; Tao, Y.; Wu, B., Thermostability improvement of the glucose oxidase from Aspergillus niger for efficient gluconic acid production via computational design. Int J Biol Macromol 2019, 136: 1060-1068. Liu, B.; Xiang, S.; Zhao, G.; Wang, B.; Ma, Y.; Liu, W.; Tao, Y., Efficient production of 3-hydroxypropionate from fatty acids feedstock in Escherichia coli. Metab Eng 2019, 51: 121-130. Hou, Y.; Chen, S.; Wang, J.; Liu, G.; Wu, S.; Tao, Y., Isolating promoters from Corynebacterium ammoniagenes ATCC 6871 and application in CoA synthesis. BMC Biotechnol 2019, 19 (1): 76. Chen, W.; Yao, J.; Meng, J.; Han, W.; Tao, Y.; Chen, Y.; Guo, Y.; Shi, G.; He, Y.; Jin, J. M.; Tang, S. Y., Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis. Nat Commun 2019, 10 (1): 960. 刘波; 陶勇, 生物制造“细胞工厂”的设计与组装. 生物工程学报 2019, 35 (10): 1942-1954. 张译文; 林白雪; 陶勇, 氨甲酰磷酸不同合成途径在大肠杆菌中的比较. 微生物学通报 2019, 46 (09): 2111-2120. Yang, Y.; Zhang, Y.; Zhang, S.; Chen, Q.; Ma, K.; Bao, L.; Tao, Y.; Yin, W.; Wang, G.; Liu, H., Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis. J Nat Prod 2018, 81 (4): 1089-1092. Wang, T.; Teng, K.; Liu, G.; Liu, Y.; Zhang, J.; Zhang, X.; Zhang, M.; Tao, Y.; Zhong, J., Lactobacillus reuteri HCM2 protects mice against Enterotoxigenic Escherichia coli through modulation of gut microbiota. Sci Rep 2018, 8 (1): 17485. Ni, K.; Zhao, J.; Zhu, B.; Su, R.; Pan, Y.; Ma, J.; Zhou, G.; Tao, Y.; Liu, X.; Zhong, J., Assessing the fermentation quality and microbial community of the mixed silage of forage soybean with crop corn or sorghum. Bioresour Technol 2018, 265: 563-567. Lu, Y.; Wang, L.; Teng, F.; Zhang, J.; Hu, M.; Tao, Y., Production of myo-inositol from glucose by a novel trienzymatic cascade of polyphosphate glucokinase, inositol 1-phosphate synthase and inositol monophosphatase. Enzyme Microb Technol 2018, 112: 1-5. Liu, Z.; Jin, Y.; Liu, W.; Tao, Y.; Wang, G., Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly amongst IspD/IspE/IspF enzymes in the MEP pathway. Biosci Rep 2018, 38 (1): BSR20171370. Li, R.; Wijma, H. J.; Song, L.; Cui, Y.; Otzen, M.; Tian, Y.; Du, J.; Li, T.; Niu, D.; Chen, Y.; Feng, J.; Han, J.; Chen, H.; Tao, Y.; Janssen, D. B.; Wu, B., Computational redesign of enzymes for regio- and enantioselective hydroamination. Nat Chem Biol 2018, 14 (7): 664-670. Han, J.; Gao, Q. X.; Zhang, Y. G.; Li, L.; Mohamad, O. A. A.; Rao, M. P. N.; Xiao, M.; Hozzein, W. N.; Alkhalifah, D. H. M.; Tao, Y.; Li, W. J., Transcriptomic and Ectoine Analysis of Halotolerant Nocardiopsis gilva YIM 90087T Under Salt Stress. Front Microbiol 2018, 9: 618. Bu, Y.; Cui, Y.; Peng, Y.; Hu, M.; Tian, Y.; Tao, Y.; Wu, B., Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design. Appl Microbiol Biotechnol 2018, 102 (8): 3675-3685. 钟瑾; 倪奎奎; 杨军香; 玉柱; 陶勇, 我国饲用草产品加工技术的现状及展望. 科学通报 2018, 63 (17): 1677-1685. 谭华荣; 陶勇; 钟瑾, 我国放线菌和乳链菌肽产生菌遗传学研究的先行者——薛禹谷. 微生物学报 2018, 58 (08): 1505-1506. 刘姣; 刘伟丰; 陶勇; 马延和, 一种大肠杆菌快速连续CRISPR基因组编辑的新策略. 微生物学通报 2018, 45 (08): 1621-1631. Yang, Y. L.; Zhang, S.; Ma, K.; Xu, Y.; Tao, Q.; Chen, Y.; Chen, J.; Guo, S.; Ren, J.; Wang, W.; Tao, Y.; Yin, W. B.; Liu, H., Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Angew Chem Int Ed Engl 2017, 56 (17): 4749-4752. Xie, Z.; Zhang, Z.; Cao, Z.; Chen, M.; Li, P.; Liu, W.; Qin, H.; Zhao, X.; Tao, Y.; Chen, Y., An external substrate-free blue/white screening system in Escherichia coli. Appl Microbiol Biotechnol 2017, 101 (9): 3811-3820. Wang, P.; Yang, X.; Lin, B.; Huang, J.; Tao, Y., Cofactor self-sufficient whole-cell biocatalysts for the production of 2-phenylethanol. Metab Eng 2017, 44: 143-149. Ni, K.; Wang, F.; Zhu, B.; Yang, J.; Zhou, G.; Pan, Y.; Tao, Y.; Zhong, J., Effects of lactic acid bacteria and molasses additives on the microbial community and fermentation quality of soybean silage. Bioresour Technol 2017, 238: 706-715. Lv, X.; Cao, H.; Lin, B.; Wang, W.; Zhang, W.; Duan, Q.; Tao, Y.; Liu, X. W.; Li, X., Synthesis of Sialic Acids, Their Derivatives, and Analogs by Using a Whole-Cell Catalyst. Chemistry 2017, 23 (60): 15143-15149. Lin, B.; Tao, Y., Whole-cell biocatalysts by design. Microb Cell Fact 2017, 16 (1): 106. Li, H.; Liang, C.; Chen, W.; Jin, J. M.; Tang, S. Y.; Tao, Y., Monitoring in vivo metabolic flux with a designed whole-cell metabolite biosensor of shikimic acid. Biosens Bioelectron 2017, 98: 457-465. Fan, K.; Lin, B.; Tao, Y.; Yang, K., Engineering deacetoxycephalosporin C synthase as a catalyst for the bioconversion of penicillins. J Ind Microbiol Biotechnol 2017, 44 (4-5): 705-710. Cui, Q.; Zhou, F.; Liu, W.; Tao, Y., Avermectin biosynthesis: stable functional expression of branched chain α-keto acid dehydrogenase complex from Streptomyces avermitilis in Escherichia coli by selectively regulating individual subunit gene expression. Biotechnol Lett 2017, 39 (10): 1567-1574. 金应福; 韩莉; 张莎莎; 李世忠; 刘伟丰; 陶勇, 通过番茄红素环化酶的优化构建β-胡萝卜素高产菌株. 生物工程学报 2017, 33 (11): 1814-1826. 唐双焱; 陶勇, 新时期下的酶工程研究. 广西科学 2017, 24 (01): 3.

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