陈川 - 河北大学 - 生命科学学院

个人简介

2006年7月，毕业于厦门大学生物化学与分子生物学专业，获博士学位。2006年9月在成都康弘药业进行抗体类和病毒类国家一类新药的研发，担任项目负责人。2009年被引进至河北大学生命科学学院工作。

研究领域

1.重组蛋白类和病毒类基因工程药物的制备及机理研究 2.基于肿瘤和糖尿病分子靶点构建抑制剂筛选平台，对生物来源的天然产物进行药物筛选；使用分子生物学.细胞生物学.生物化学和药理学的方法研究药物的作用的机理，并探索肿瘤和糖尿病新的药物作用靶点

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Chen C, Cao M, Zhu S, Wang C, Liang F, Yan L, Luo D, Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2, Sci Rep, 2015, 5:17626 2.Chen C, Wang CC, Wang Z, Geng WY, H Xu, Song SM , Luo DQ, Cytotoxic activity of a synthetic deoxypodophyllotoxin derivative with an opened D-ring, 2016, DOI:10.1080/10286020.2015.1131679 3.Chen C, Hu SY, Luo DQ, Zhu SY, Zhou CQ, Potential antitumor agent from the endophytic fungus Pestalotiopsis photiniae induces apoptosis via the mitochondrial pathway in HeLa cells, Oncology Rep, 2013, 30: 1773-1781 4.Chen C, Yang RL, A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells, Brazilian Journal of Medical and Biological Research, 2013,46: 643-649 5.Liu L, Zhang J, Chen C, Teng J, Wang C, Luo D.Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea, Fungal Genet Biol, 2015,81:191-200. 6.Liu ZQ, Liu T, Chen C, Li MY, Wang ZY, Chen RS, Wei GX, Wang XY, Luo DQ, Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice, Toxicol Appl Pharmacol, 2015, 285:61-70 7.Wei PY, Liu LX, Liu T, Chen C, Luo DQ, Shi BZ, Three new pigment protein tyrosine phosphatases inhibitors from the insect parasite fungus Cordyceps gracilioides: terreusinone A, pinophilin C and cryptosporioptide A, Molecules,2015 20:5825-34 8.Chen C, Hu SY, Luo DQ, Zhu SY, Zhou CQ. Potential antitumor agent from the endophytic fungus Pestalotiopsis photiniae induces apoptosis via the mitochondrial pathway in HeLa cells. Oncology Rep. 30: 1773-1781, 2013 9.Luo DQ*, Chen YP, Zhang J, Chen C*. A New Glycine Derivative and a New Indole Alkaloid from the Fermentation Broth of the Plant Endophytic Fungus Pestalotiopsis podocarpi Isolated from the Chinese Podocarpaceae Plant Podocarpus macrophyllus. Helvetica Chimica Acta . 96: 309-312, 2013 10.Chen C, Huang CX, Chen SH, Liang J, Lin WB, Tao T, et al. Subunit–subunit interactions in the human 26S proteasome. Proteomics 8: 508-520, 2008. 11.Chen C, Tao tao. An interaction map of Chinese liver 26S proteasome subunits. Mol. Cell. Proteomics 2006, 5:S607. 12. 陈川, 朱思宇, 李丽, 胡淑媛, 罗都强.常规PCR法快速鉴别粗品肝素钠不同种属来源. 药学学报, 2014 13.陈川, 俞德超, 滕理送. 以VEGF/VEGFR为靶点的抗肿瘤药物的研究进展.中国肿瘤生物治疗杂志, 3:35-38, 2007. 14.陈川,王三英.嗜水气单胞菌耐四环素的蛋白质组学初步研究.微生物学报,44:396-398, 2004.