吴琛 - 河北大学 - 生命科学学院

个人简介

1995年至1999年就读于河北大学生物系生物学专业，获学士学位；1999年至2002年就读于河北大学生命科学学院动物学专业，获硕士学位。2007年毕业于中国人民解放军军事医学科学院基础医学研究所，获博士学位。2009年1月-2010年12月于河北大学生物学博士后流动站从事博士后工作。分别于2014年及2017年赴美国Fred Hutchinson Cancer Research Center和City of Hope Medical Center进行访问学习。

研究领域

1）异常糖基化对肿瘤细胞生物学行为的影响及机制 2）DNA损伤修复机制及表观遗传修饰在肿瘤发生发展中的分子机制研究

近期论文

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1.Xiangfei Wang, Xiumin Wang, Yang Liu, Yating Dong, Yanan Wang, Muzaffer Ahmad Kassab, Wufang Fan, Xiaochun Yu*, Chen Wu*. LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway. Oncogenesis. 2018,7:57 2.Jinshuai Shan, Yang Liu, Yukun Wang, Yimiao Li, Xiaochun Yu*, Chen Wu*. GALNT14 Involves the Regulation of Multidrug Resistance in Breast Cancer Cells. Translational Oncology. 2018, 11(3):786-793 3.Tao Zuo, Jinshuai Shan, Yang Liu, Rong Xie, Xiaochun Yu*, Chen Wu*. EFEMP2 Mediates GALNT14-Dependent Breast Cancer Cell Invasion. Translational oncology. 2018, 11(2):346-352 4.Cohen SA#, Wu C#, Yu M, Gourgioti G, Wirtz R, Raptou G, Gkakou C, Kotoula V, Pentheroudakis G, Papaxoinis G, Karavasilis V, Pectasides D, Kalogeras KT, Fountzilas G, Grady WM. Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. Clin Colorectal Cancer. Clin Colorectal Cancer. 2016,15(2):164-169（*Co-first author） 5.Tian Huanna, Zuo Tao, Wang Xiangfei, An Longfei, Xie Yuanyuan, Wang Jianhua, Zhang Cuifang, Jiao Manjing, Cao Wenjing, Qin Shaochuan, Xu Feifei, Li Naikang, Zhang Jinchao, Wu Chen*. GALNT14 mediates tumor invasion and migration in breast cancer cell MCF-7. Molecular Carcinogenesis. 2015, 54(10):1159-1171 6.Chen Wu#, Yuanyuan Xie, Feng Gao, Yanan Wang, Yawei Guo, Huanan Tian, Yanshuang Li, Wufang Fan. Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. GENE, 2013, 525(1):18-25 7.Chen Wu*, Xiaobo Liu, Yuanyuan Wang, Huanna Tian, Yuanyuan Xie, Qinjian Li, Xiaokang Zhang, Fangming Liu. Insulin-like factor binding protein-3 promotes the G1 cell cycle arrest in several cancer cell lines. GENE, 2013,512（1）：127-133 8.Chen Wu*, Si-Si Ma, Jian-Feng Ge, Yuan-Yuan Wang, Huan-Na Tian, Xiao-Bo Liu, Bo Zhang, Fang-Min Liu, Xiao-Kang Zhang, Qin-Jian Li. Colocalization and Identification of Interaction Sites between IGFBP-3 and GalNAc-T14. GENE, 2012, 499(2):347-51 9.Chen Wu*, Xiaodan Guo, Weina Wang et al. N-Acetylgalactosaminyltransferase-14 as a potential biomarker for Breast Cancer by Immunohistochemistry. BMC cancer. 2010, 10, 123 10.Chen Wu#, Yaojun Shan, Xinxia Liu, Wenqian Song, Jiali Wang, Minji Zou, Min Wang, Donggang Xu. GalNAc-T14 may be involved in the regulation of apoptotic action of IGFBP-3. Journal of Biosciences. 2009,34(3):389-395 11.C Wu#, M J Zou, Y Y Wang, G Y Yao, P Wei, G Y Chen, J X Wang, D G Xu. Prokaryotic expression, purification, and production of polyclonal antibody against a human polypeptide N-acetylgalactosaminyltransferase 14. Protein Expression and Purification. 2007，56(1):1-7 12.C Wu#, GY Yao, MJ Zou et al. N-acetylgalactosaminyltransferase 14, A novel Insulin-like Growth Factor-binding Protein-3 Binding Partner. Biochemical and Biophysical Research Communications，2007,357(2):360-365