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KEY: * = Corresponding Author (Senior Author).
Total citations: >6300; H-index: 43
106. Liu, X.J. & Chen, F. * (2003). Cell differentiation and colony alteration of Nostoc flagelliforme, an edible terrestrial cyanobacterium, in different liquid suspension cultures. Folia Microbiologica, 48 (5), 619-626.
105. Wang, S.B., Hu, Q., Sommerfeld, M. & Chen, F.* (2003). An optimized protocol for isolation of soluble proteins from microalgae by two-dimensional gel electrophoresis analysis. Journal of Applied Phycology, 15, 485-496.
104. Lu, H.T., Jiang, Y. & Chen, F. (2003). Application of high-speed counter-current chromatography to the preparative separation and purification of baicalin from the Chinese medicinal plant Scutellaria baicalensis. Journal of Chromatography A, 1017,117-123.
103. Lai, J.P., He, X.W. & Chen, F. * (2003). Separation and determination of the antitumor drug piritrexim by molecularly imprinted microspheres in high performance liquid chromatography. Analytical and Bioanalytical Chemistry, 377(1), 208-213.
102. Liu, X.J., Chen, F.* & Jiang, Y. (2003). Differentiation of Nostoc flagelliforme , and its neighboring species using , fatty acid profiling as a chemotaxonomic tool. Current Microbiology, 47 (6), 467-474.
101. Wen, Z.Y. & Chen, F. * (2003). Heterotrophic production of eicosapentaenoic acid by microalgae. Biotechnology Advances, 21(4), 273-294. [Invited Article].
100. Li, X.Z., Dong, X.L., Zhao, C.X., Chen, Z. & Chen, F. (2003). Isolation and some properties of cellulose-degrading Vibrio sp. LX-3 with agar-liquefying ability from soil. World Journal of Microbiology & Biotechnology, 19, 375-379.
99. Lu, H.T., Jiang, Y. & Chen, F. * (2003). Preparative separation and purification of squalene from the microalga Thraustochytrium sp. by high-speed counter-current chromatography. Journal of Chromatography A, 994, 37-43.
98. Lai, J.P., He, X.W., Jiang, Y. & Chen, F. * (2003). Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait by molecularly imprinted solid phase extraction. Analytical and Bioanalytical Chemistry, 375, 264-269.
97. Wen, Z.Y. & Chen, F. * (2002). Perfusion culture of the diatom Nitzschia laevis for ultra-high yield production of eicosapentaenoic acid. Process Biochemistry, 38, 523-529.
96. Zhong, J.J., Pan, Z.W., Wang, Z.Y., Wu, J.Y., Chen, F., Takagi, M. & T. Yoshida (2002). Effect of mixing time on taxoid production in suspension cultures of Taxus chinensis in a centrifugal impeller bioreactor. Journal of Bioscience and Bioengineering, 94 (3), 244-250.
95. Shi, X.M., Jiang, Y. & Chen, F. * (2002). High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch culture. Biotechnology Progress, 18, 723-727.
94. Wen, Z.Y., Jiang, Y. & Chen, F. * (2002). High cell density culture of the diatom Nitzschia laevis for eicosapentaenoic acid production: fed-batch development. Process Biochemistry, 37, 1447-1453.
93. Li, H.B., Jiang, Y. & Chen, F. * (2002). Isolation and purification of lutein from the microalga Chlorella vulgaris by extraction after separation. Journal of Agricultural and Food Chemistry, 50, 1070-1072.
92. Li, H.B., Lai, J.P., Jiang, Y. & Chen, F. * (2002). Preparative isolation and purification of salvianolic acid B from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter-current chromatography. Journal of Chromatography A, 943(2), 235-239.
91. Wen, Z.Y. & Chen, F. * (2002). Continuous cultivation of the diatom Nitzschia laevis for eicosapentaenoic acid production: physiological study and process optimization. Biotechnology Progress, 18, 21-28.
90. Yuan, J.P., Chen, F.*, Liu, X. & Li, X.Z. (2002). Carotenoid composition in the green microalga Chlorococcum. Food Chemistry, 76(3), 319-325.
89. Li, H.B. & Chen, F. * (2001). Preparative isolation and purification of salidroside from the Chinese medicinal plant Rhodiola sacchalinensis by high-speed counter-current chromatography. Journal of Chromatography A, 932, 91-95.
88. Fan, W.K., Chen, F., Jones E.B.G. & Vrijmoed L.L.P. (2001). Eicosapentaenoic acid and docosahexaenoic acid production and okara uilizing potential of thraustochytrids. Journal of Industrial Microbiology & Biotechnology. 27(4), 199-202.
87. Wen, Z.Y. & Chen, F. * (2001). A perfusion-cell bleeding strategy for enhancing the productivity of eicosapentaenoic acid in the culture of Nitzschia laevis. Applied Microbiology and Biotechnology, 57, 316-322.
86. Wen, Z.Y. & Chen, F. * (2001). Optimization of nitrogen sources for heterotrophic production of eicosapentaenoic acid by the diatom Nitzschia laevis. Enzyme and Microbial Technology, 29, 341-347.
85. Wen, Z.Y. & Chen, F. * (2001). Application of statistically-based experimental designs for the optimization of eicosapentaenoic acid production by the diatom Nitzschia laevis. Biotechnology and Bioengineering, 75 (2), 159-169.
84. Li, H.B. & Chen, F. * (2001). Simultaneous determination of twelve water- and fat-soluble vitamins by high-performance liquid chromatography with diode array detection. Chromatographia, 54, 270-273.
83. Li, H.B. & Chen, F. * (2001). Preparative isolation and purification of six diterpenoids from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter-current chromatography. Journal of Chromatography A, 925, 109-114.
82. Li, H.B. & Chen, F. * (2001). Preparative isolation and purification of astaxanthin from the microalga Chlorococcum sp. by high-speed counter-current chromatogaphy. Journal of Chromatography A, 925, 133-137.
81. Yuan, J.P. & Chen, F.* (2001). Indirect photometric ion chromatographic analysis of anions in Haematococcus pluvialis culture media. Biotechnology Letters, 23(10), 757-760. (IF: 1.676)
80. Ma, R.Y.N. & Chen, F. * (2001). Enhanced production of free trans-astaxanthin by oxidative stress in the cultures of the green microalga Chlorococcum sp. Process Biochemistry, 36(12), 1175-1179.
79. Li, H.B., Chen, F. * & Xu, X.R. (2001). Determination of iodide in seawater and urine by size exclusion chromatography with iodine-starch complex. Journal of Chromatography A, 918, 335-339.
78. Li, H.B. & Chen, F. * (2001). Simultaneous determination of nine water-soluble vitamins in pharmaceutical preparations by high-performance liquid chromatography with diode array detection. Journal of Separation Science, 24, 271-274.
77. Yuan, J.P. & Chen, F. * (2001). Kinetics for the reversible isomerization reaction of trans-astaxanthin. Food Chemistry, 73(2), 131-137.
76. Ma, R.Y.N. & Chen, F. * (2001). Induction of astaxanthin formation by reactive oxygen species in mixotrophic culture of Chlorococcum sp. Biotechnology Letters, 23(7), 519-523.
75. Li, H.B., Chen, F. *, Zhang, T.Y., Yang, F.Q. & Xu, G.Q. (2001). Preparative isolation and purification of lutein from the microalga Chlorella vulgaris by high-speed counter-current chromatography. Journal of Chromatography A, 905, 151-155.
74. Li, H.B. & Chen, F. * (2000). Determination of viatmin B12 in pharmaceutical preparations by a highly sensitive fluorimetric method. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 368(8), 836-838.
73. Fan, K.W., Chen, F., Jones, E.B.G. & Vrijmoed, L.L.P. (2000). Utilization of food processing waste by Thraustochytrids. Fungal Diversity, 5, 185-194.
72. Wen, Z.Y. & Chen, F. * (2000). Heterotrophic production of eicosapentaenoic acid by the diatom Nitzschia laevis: effects of silicate and glucose. Journal of Industrial Microbiology and Biotechnology, 25, 218-224.
71. Chen, H., Chen, F. *, Chiu, F.C.K. & Lo, C.M.Y. (2001). The effect of yeast elicitor on the growth and secondary metabolism of hairy root cultures of Salvia miltiorrhiza. Enzyme and Microbiology Technology, 28, 100-105.
70. Vonshak, A., Cheung, S.M. & Chen, F. (2000). Mixotrophic growth modifies the response of Spirulina (Arthrospira) platensis (cyanobacteria) cells to light. Journal of Phycology, 36, 675-679.
69. Li, H.B. & Chen, F. * (2000). A highly sensitive fluorimetric method for the determination of fluoride in biological material with Al 3+-calcein complex. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 5, 501-504.
68. Li, H.B., Chen, F. * & Xu, X.R. (2000). A highly sensitive spectrophotometric method with solid phase extraction for the determination of methylmercury in human hair. Journal of Analytical Toxicology, 24(8), 704-707.
67. Li, H.B., Chen, F. * & Jiang, Y. (2000). Determination of vitamin B12 in multivitamin tablets and fermentation medium by high performance liquid chromatography with fluorescence detection, Journal of Chromatography A, 891(2), 243-247.
66. Jiang, Y. & Chen, F. * (2000). Effects of temperature and temperature shift on docosahexaenoic acid production by the marine microalga Crypthecodinium cohnii. Journal of the American Oil Chemists Society, 77, 613-617.
65. Jiang, Y. & Chen, F. * (2000). Effects of medium glucose concentration and pH on docosahexaenoic acid content of heterotrophic Crypthecodinium cohnii. Process Biochemistry, 35, 1205-1209.
64. Shi, X.M., Zhang, X.W. & Chen, F. * (2000). Heterotrophic production of biomass and lutein by Chlorella protothecoides on various nitrogen sources. Enzyme and Microbial Technology, 27, 312-318.
63. Chen, H. & Chen, F. * (2000). Induction of phytoalexin formation in crown gall and hairy root cultures of Salvia miltiorrhiza by methyl viologen. Biotechnology Letters, 22(8), 715-720.
62. Wen, Z.Y. & Chen, F. * (2000). Production potential of eicosapentaenoic acid by the diatom Nitzschia laevis. Biotechnology Letters, 22(9), 727-733.
61. Li, H.B. & Chen, F. * (2000). Determination of silicate in water by ion exclusion chromatograpghy with conductivity detection. Journal of Chromatography A, 874(1), 143-147.
60. Li, H.B., Chen, F. * & Xu, X.R. (2000). Fluorimetric determination of methylmercury as an ion-association complex with rhodamine B in the presence of iodide. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 367(5), 499-501.
59. Wen, Z.Y., Teng, X.W. & Chen, F. * (2000). A novel perfusion system for hybridoma cell cultures by two step sequential sedimentation. Journal of Biotechnology, 79, 1-11.
58. Chen, H. & Chen, F. * (2000). Effects of yeast elicitor on the growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture. Process Biochemistry, 35, 837-840.
57. Zhang, X.W., Shi, X.M. & Chen, F. * (1999). A kinetic model for lutein production by the green microalga Chlorella protothecoides in heterotrophic culture. Journal of Industrial Microbiology & Biotechnology, 23(6), 503-507.
56. Chen, H. & Chen, F. * (2000). Effect of yeast elicitor on the secondary metabolism of Ti transformed Salvia miltiorrhiza cell suspension cultures. Plant Cell Reports, 19(7), 710-717.
55. Zhong, J.J., Chen, F. & Hu, W.W. (2000). High density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin. Process Biochemistry, 35, 491-496.
54. Yuan, J.P. & Chen, F. * (2000). Purification of trans-astaxanthin from a high-yielding astaxanthin ester-producing strain of the microalga Haematococcus pluvialis. Food Chemistry, 68, 443-448.
53. Jiang, Y. & Chen, F. * (1999). Effects of salinity on cell growth and docosahexaenoic acid content of the heterotrophic marine microalga Crypthecodinium cohnii. Journal of Industrial Microbiology & Biotechnology, 23(6), 508-513.
52. Ren, G. & Chen, F. * (2000). Drying of steamed Asian ginseng (Panax ginseng) roots by microwave-hot air combination. Pharmazie, 55(2), 124-128.
51. Ren, G., Zhang, X.W. & Chen, F. * (2000). Predicting colour kinetics during red Asian ginseng (Panax ginseng) preparation. Pharmazie, 55(4), 300-302.
50. Chen, Q., Chen, F. & Li, Z.Y. (1999). Preparation and surfactant properties of amino acid based surfactants. Chinese Chemical Letters, 10(9), 789-792.
49. Zhang X.W., Chen, F. * & Johns, M.R. (1999). Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fed-batch cultures. Process Biochemistry, 35, 385-389.
48. Yuan, J.P. & Chen, F. * (1999). Isomerization of trans-astaxanthin in organic solvents. Journal of Agricultural & Food Chemistry, 47, 3656-3660.
47. Zhang, X.W., Gong, X.D. & Chen, F. * (1999). Dynamics and stability analysis of the growth and astaxanthin production system of Haematococcus pluvialis. Journal of Industrial Microbiology & Biotechnology, 23(2), 133-137.
46. Chen, H., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1999). Production of rosmarinic acid and lithospermic acid B in Ti transformed Salvia miltiorrhiza cell suspension cultures. Process Biochemistry, 34, 777-784.
45. Jiang, Y., Chen, F. * & Liang, S.Z. (1999). Production potential of docosahexaenoic acid by the heterotrophic marine dinoflagellate Crypthecodinium cohnii. Process Biochemistry, 34, 633-637.
44. Chen, H. & Chen, F. * (1999). Effects of methyl jasmonate and salicylic acid on cell growth and cryptotanshinone formation in Ti transformed Salvia miltiorrhiza cell suspension cultures. Biotechnology Letters, 21(9), 803-807.
43. Zhang, Y.M. & Chen, F. * (1999). A simple method for efficient separation and purification of c-phycocyanin and allophycocyanin from Spirulina platensis. Biotechnology Techniques (changed to Biotechnology Letters), 13(9), 601-603.
42. Chen, H. & Chen, F. * (1999). Kinetics of cell growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension cultures. Biotechnology Letters, 21(8), 701-705.
41. Zhang, X.W., Gong, X.D. & Chen, F.* (1999). Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis. Journal of Industrial Microbiology Biotechnology, 23, 691-696.
40. Boussiba, S., Wang, B., Yuan, J.P., Zarka. A. & Chen, F.* (1999). Changes in pigment profile in the green alga Haematococcus pluvialis exposed to environmental stresses. Biotechnology Letters, 21, 601-604.
39. Zhang, X.W., Zhang, Y.M. & Chen, F.* (1999). Application of mathematical models to the determination optimal glucose concentration and light intensity for mixotrophic culture of Spirulina platensis. Process Biochemistry, 34(5), 477-481.
38. Shi, X.M., Liu, H.J., Zhang, X.W. & Chen, F.* (1999). Production of biomass and lutein by Chlorella protothecoides at various glucose concentrations in heterotrophic cultures. Process Biochemistry, 34(4), 341-347.
37. Ren, G. & Chen, F. * (1999). Simultaneous quantification of ginsenosides in American ginseng (Panax quinquefolium) root powder by visible/near infrared reflectance spectroscopy. Journal of Agricultual & Food Chemistry, 47, 2771-2775.
36. Chen, H., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1999). Production of lithospermic acid B and rosmarinic acid in hairy root cultures of Salvia miltiorrhiza. Journal of Industrial Microbiology & Biotechnology, 22, 133-138.
35. Ren, G. & Chen, F. * (1999). Degradation of ginsenosides in American ginseng (Panax quiquefolium) extracts during microwave and conventional heating. Journal of Agricultural & Food Chemistry, 47(4), 1501-1505.
34. Shi, X.M. & Chen, F. * (1999). Production and rapid extraction of lutein and the other lipid-soluable pigments from Chlorella protothecoides grown under heterotrophic and mixotrophic conditions. Nahrung/Food (changed to Molecular Nutrition and Food Research), 43(2), 109-113.
33. Yuan, J.P. & Chen, F. * (1999). Simultaneous separation and determination of sugars, ascorbic acid and furanic compounds by HPLC-dual detection. Food Chemistry, 64(3), 423-427.
32. Yuan, J.P. & Chen, F. * (1999). Hydrolysis kinetics of astaxanthin esters and stability of astaxanthin of Haematococcus pluvialis during saponification. Journal of Agricultural & Food Chemistry, 47(1), 31-35.
31. Zhang, X.W., Zhang, Y.M. & Chen, F.* (1998). Kinetic models for phycocyanin production by high cell density mixotrophic culture of the microalga Spirulina platensis. Journal of Industrial Microbiology & Biotechnology, 21(6), 283-388.
30. Yuan, J.P. & Chen, F. * (1998). Degradation of ascorbic acid in aqueous solution. Journal of Agricultural & Food Chemistry, 46(12), 5078-5082.
29. Vazhappilly, R. & Chen, F. * (1998). Heterotrophic production potential of omega-3 polyunsaturated fatty acids by microalgae and algae-like microorganisms. Botanica Marina, 41, 553-558.
28. Yuan, J.P. & Chen, F. * (1998). Chromatographic separation and purification of trans-astaxanthin from the extracts of Haematococcus pluvialis. Journal of Agricultural & Food Chemistry, 46(8), 3371-3375.
27. Li, X., Lin, W., Gao, P. & Chen, F. (1998). Endoglucanase S, a novel endocellulase exhibiting exoglucanase activity from a newly isolated Streptomyces sp. LX. Journal of Applied Microbiology, 85, 347-356.
26. Yuan, J.P., Chen, H. & Chen, F. * (1998). Simultaneous determination of rosmarinic acid, lithospermic acid B and related phenolics in Salvia miltiorrhiza by HPLC. Journal of Agricultural & Food Chemistry, 46(7), 2651-2654.
25. Li, X. & Chen, F. * (1998). Improvement in isolation of gliding bacteria by the elimination of soluable sugars. Biotechnology Techniques (changed to Biotechnology Letters), 12(5), 343-345.
24. Ren, G. & Chen, F. * (1998). Drying of American ginseng (Panax quinquefolium) roots by microwave-hot air combination. Journal of Food Engineering, 35(4), 433-443.
23. Gong, X. & Chen, F. * (1998). Influence of medium components on astaxanthin content and production of Haematococcus pluvialis. Process Biochemistry, 33(4), 385-391.
22. Yuan, J.P. & Chen, F. * (1998). Separation and identification of furanic compounds in fruit juices and drinks by HPLC-PDA detection. Journal of Agricultural & Food Chemistry, 46, 1286-1291.
21. Vazhappilly, R. & Chen, F. * (1998). Eicosapentaenoic acid and docosahexaenoic acid production potential of microalgae and their heterotrophic growth. Journal of the American Oil Chemists Society, 75, 393-397.
20. Chen, H., Yuan, J.P., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1997). Tanshinone production in Ti transformed Salvia miltiorrhiza cell suspension cultures. Journal of Biotechnology, 58(3), 147-156.
19. Chen, F. *, Chen, H. & Gong, X. (1997). Mixotrophic and heterotrophic growth of Haematococcus lacustris and rheological behaviour of the cell suspensions. Bioresource Technology, 62(1-2), 19-24.
18. Gong, X.D. & Chen, F. * (1997). Optimization of culture medium for growth of Haematococcus pluvialis. Journal of Applied Phycology, 9(5), 437-444.
17. Shi, X.M., Chen, F. *, Yuan, J.P. & Chen, H. (1997). Heterotrophic production of lutein by selected Chlorella strains. Journal of Applied Phycology, 9(5), 445-450.
16. Ren, G., Chen, F. *, Lian, H., Zhao, J. and Gao, X. (1997). Changes in hormone contents of Panax quinquefolium seeds during stratification. Journal of Horticultural Science (changed to Journal of Horticultural Science & Biotechnology) , 72(6), 901-906.
15. Gong, X.D. & Chen, F. * (1997). Rapid detection of heterotrophic growth of Haematococcus pluvialis using indirect conductimetry. Biotechnology Techniques (changed to Biotechnology Letters), 11(11), 841-844.
14. Ren, G. and Chen, F. * (1997). Determination of moisture content of ginseng by near infra-red reflectance spectroscopy. Food Chemistry, 60, 433-436.
13. Yuan, J.P. & Chen, F. * (1997). Identification of astaxanthin isomers in Haematococcus lacustris by HPLC-photodiode array detection. Biotechnology Techniques (changed to Biotechnology Letters), 11(7), 455-459.
12. Yuan, J.P., Gong, X.D. & Chen, F. * (1997). Separation and analysis of carotenoids and chlorophylls in Haematococcus lacustris by high-performance liquid chromatography photodiode array detection. Journal of Agricultural & Food Chemistry, 45(5), 1952-1956.
11. Chen, F. * & Zhang, Y. (1997). High cell density mixotrophic culture of Spirulina platensis on glucose for phycocyanin production using a fed-batch system. Enzyme and Microbial Technology, 20, 221-224. (
10. Shi, X.M. and Chen, F. * (1997). Stability of lutein under various storage conditions. Nahrung/Food (changed to Molecular Nutrition and Food Research), 41(1), 38-41.
9. Chen, F.* (1996). High cell density culture of microalgae in heterotrophic growth. Trends in Biotechnology, 14(11), 421-426 [featured in the cover of the journal; the article was also cited by a landmark article in Science (292: 2073-2075, 2001) as one of the major reasons they initiated the study].
8. Chen, F. *, Zhang, Y. & Guo, S. (1996). Growth and phycocyanin formation of Spirulina platensis in photoheterotrophic culture. Biotechnology Letters, 18(5), 603-608.
7. Chen, F. * & Johns, M.R. (1996). Heterotrophic growth of Chlamydomonas reinhardtii on acetate in chemostat culture. Process Biochemistry, 31(6), 601-604.
6. Chen, F. & Johns, M.R. (1996). High cell density culture of Chlamydomonas reinhardtii on acetate using fed-batch and hollow-fibre cell-recycle systems. Bioresource Technology, 55(2), 103-110.
5. Chen, F. * & Johns, M.R. (1996). Relationship between substrate inhibition and maintenance energy of Chlamydomonas reinhardtii in heterotrophic culture. Journal of Applied Phycology, 8(1), 15-19.
4. Yuan, J.P., Gong X.-D. & Chen, F. * (1996). Separation and identification of astaxanthin esters and chlorophylls in Haematococcus lacustris by HPLC. Biotechnology Techniques (changed to Biotechnology Letters), 10(9), 655-660.
3. Chen, F. *& Johns, M.R. (1995). A strategy for high cell density culture of heterotrophic microalgae with inhibitory substrates. Journal of Applied Phycology, 7, 43-46.
2. Chen, F. * & Johns, M.R. (1994). Substrate inhibition of Chlamydomonas reinhardtii by acetate in heterotrophic culture. Process Biochemistry, 29, 245-252.
1. Chen, F.* & Johns, M.R. (1991). Effect of C/N ratio and aeration on the fatty acid composition of heterotrophic Chlorella sorokiniana. Journal of Applied Phycology, 3, 203-209.