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个人简介

于1977年至1982年在山东农学院接受本科教育,1985年至1992年在加拿大阿尔伯塔大学学习,获硕士和博士学位。1992年至1995年间在加拿大多伦多大学完成博士后工作。1995年起在美国红十字协会Holland医学生物研究所和乔治华盛顿大学任助理教授,于1999年晋升为终身副教授。2001年在美国新泽西医科齿科大学-罗伯特?伍德?约翰逊医学院任终身副教授并于2003年晋升为终身教授,并成为该大学首席大学教授。

研究领域

致力于细胞凋亡领域的研究,尤其是T细胞凋亡方面。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Wang Y, Chen X, Cao W, Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nature Immunology. 2014 Nov. 15 (11). In press. 2. Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The roles of testicular c-kit positive cells in de novo morphogenesis of testis. Science Reports. 2014 Aug 4;4:5936. 3. Yin S, Yang J, Lin B, Deng W, Zhang Y, Yi X, Shi Y, Tao Y, Cai J, Wu CI, Zhao G, Hurst LD, Zhang J, Hu L, Kong X. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Science Reports. 2014 Aug 12;4:6036. 4. Shi Y. The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease. Cell Death and Disease (2014) 5, e1062; doi:10.1038/cddis.2014.50 5. Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y, Brewer G, Shi Y. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ. 2014 Jul 18. doi: 10.1038/cdd.2014.85. 6. Ma S, Xie N, Li W, Yuan B, Shi Y*, Wang Y*. Immunobiology of mesenchymal stem cells. Cell Death Differ. 2014 Feb;21(2):216-25. 7. Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu C, Xie Q, Zhang Y, Wan B, Zhang Y. Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology. 2014 Feb;59(2):671-82. 8. Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol. 2014 Jul 15;54C:89-97. doi: 10.1016/j.biocel.2014.07.005. 9. Yang X, Han ZP, Zhang SS, Zhu PX, Hao C, Fan TT, Yang Y, Li L, Shi Y, Wei LX. Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation. Cell Death Dis. 2014 Jun 26;5:e1308. doi: 10.1038/cddis.2014.257. 10. Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X. A microRNA miR-221- and miR-222-mediated feedback loop, via PDLIM2, maintains constitutive activation of nuclear factor κB and STAT3 in colorectal cancer cells. Gastroenterology. 2014 Jun 12. pii: S0016-5085(14)00744-6. doi: 10.1053/j.gastro.2014.06.006. 11. Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H. Autocrine IL-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels. Stem Cells. 2014 Oct;32(10):2799-810. doi: 10.1002/stem.1763. 12. Cao G, Yang Q, Zhang SY, Xu CL, Roberts, AI, Wang Y, Shi YF. Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4. Brain, Behavior and Immunity. 2014 May;38:125-32. doi: 10.1016/j.bbi.2014.01.013. Epub 2014 Jan 27. 13. Chen X, Gan Y, Li W, Su J, Zhang Y, Huang Y, Roberts AI, Han Y, Li J, Wang Y, Shi Y. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis. 2014 Jan 23;5:e1009. doi: 10.1038/cddis.2013.537. 14. Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI, Wang Y, Shi Y. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res. 2014 Jan 22. 15. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 2014 Jan 16;40(1):140-52. 16. Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y. TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells. J Immunol. 2014 Jan 1;192(1):103-9. doi: 10.4049/jimmunol.1302164. Epub 2013 Nov 29. 17. Ren G, Liu Y, Zhao X, Zhang J, Zheng B, Yuag Z, Zhang L, Tischfield J, Shao C, Shi Y. Tumor resident mesenchymal stromal cells endow na?ve stromal cells with tumor-promoting properties. Oncogene. 2014 Jul 24;33(30):4016-20. doi: 10.1038/onc.2013.387. Epub 2013 Sep 30. 18. Huang Y, Yu P, Li W, Ren G, Roberts, AI, Cao W, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Zhang L, Xie N, Wang Y and Shi Y. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene. 2014 Jul 17;33:3830-3838. doi: 10.1038/onc.2013.355. Epub 2013 Aug 26. 19. Su J, Chen X, Huang Y, Li W, Li J, Cao K, Cao G, Zhang L, Li F, Roberts AI, Kang H, Yu P, Ren G, Ji W, Wang Y, Shi Y. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differentiation. 2014 Mar;21(3):388-96. doi: 10.1038/cdd.2013.149. Epub 2013 Oct 25. 20. Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells. 2014 Feb;32(2):327-37. doi: 10.1002/stem.1567.

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