张思河 - 南开大学

个人简介

教育经历 2001.9 – 2004.7 第四军医大学（现空军军医大学）细胞生物学博士 1995.9 – 1998.7 解放军兽医大学（现吉林大学和平分校）遗传学硕士 1991.9 – 1995.7 西北农业大学（现西北农林科技大学）遗传学学士工作经历 2020.01-至今南开大学医学院教授 2011.10-2019.12 南开大学医学院副教授 2006.9-2009.12 瑞典隆德大学医院肿瘤科博士后 2005.9-2011.9 第四军医大学细胞工程研究中心副教授 2000.9-2005.8 第四军医大学细胞工程研究中心讲师 1998.9-2000.8 第四军医大学医学细胞生物学教研室助教

研究领域

（1）囊泡转运调控机制。聚焦膜抗原转运异常与癌细胞恶性表型关系（2）大分子药物内化递送。解析穿膜肽与大分子药物复合体内化调节机制（3）新功能抗体药物。研发肿瘤微环境响应型重组抗体和抗体交联药物

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Qi S#, Su L#, Li J#, Zhang C, Ma Z, Liu G, Zhang Q, Jia G, Piao Y, Zhang S*.Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes. J Exp Clin Cancer Res. 2019, 38(1):471. Qi S, Su L, Li J, Zhao P, Zhang Q, Niu X, Liu J, Jia G, Wei X, Tavernier J, Jiang J, Chen Z, Zhang S*.YIPF2 is a novel Rab-GDF that enhances HCC malignant phenotypes by facilitating CD147 endocytic recycle. Cell Death Dis. 2019, 10(6):462. Zhang Q, Gao H, Li D, Li Z, Qi S, Zheng S, Bai C, Zhang S*. Clinical outcome of Escherichia coli bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study. Infect Drug Resist. 2019,12:359-371. Niu X, Su L, Qi S, Gao Z, Zhang Q, Zhang S*. GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway. Cell Death Dis. 2018, 9(10):971. Niu X, Gao Z, Qi S, Su L, Yang N, Luan X, Li J, Zhang Q, An Y, Zhang S*. Macropinocytosis activated by oncogenic Dbl enables specific targeted delivery of Tat/pDNA nano-complexes into ovarian cancer cells. Int J Nanomedicine. 2018,13:4895-4911. Gao Z, Niu X, Zhang Q, Chen H, Gao A, Qi S, Xiang R, Belting M, Zhang S*. Mitochondria chaperone GRP75 moonlighting as a cell cycle controller to derail endocytosis provides an opportunity for nanomicrosphere intracellular delivery. Oncotarget. 2017, 8(35):58536-58552. Zhang Q, Zhang W, Li Z, Bai C, Li D, Zheng S, Zhang P, Zhang S*. Bacteraemia due to AmpC β-lactamase-producing Escherichia coli in hospitalized cancer patients: risk factors, antibiotic therapy, and outcomes. Diagn Microbiol Infect Dis. 2017, 88(3):247-251. Liu J#, Zhang Q#, Chen H, Gao Z, Li Y, Sun Z, Xiang R, Zhang S*. Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery. Oncotarget. 2016, 7(25):38105-38121. Chen H, Gao Z, He C, Xiang R, van Kuppevelt TH, Belting M, Zhang S*. GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA. Exp Cell Res. 2016, 343(2):223-36. Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, Li Y, Cui HY, Guo YS, Tavernier J, Zhang SH*, Jiang JL*, Chen ZN*. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in HCC cells. Hepatology. 2011,54(6):2012-24. Zhao P, Zhang W, Tang J, Ma XK, Li Y, Jiang JL*, Zhang SH*,Chen ZN*. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer Sci.2010,101(2):387–395. Wittrup A, Zhang SH, P. Kucharzewska, Johansson M, Welch J, Mörgelin M, Belting M*. Magnetic nanoparticle based isolation of endocytic vesicles reveals a functional role of the heat shock protein GRP75 in macromolecular delivery. Proc Natl Acad Sci U S A. 2010，107(30):13342-7.