个人简介
学科方向 药物设计的结构基础
杨卓教授，南开大学医学院教授，博士生导师， 1983年毕业于天津医科大学临床医学专业， 获学士学位。1989年于浙江大学医学院，获医学硕士学位。1998年在英国伯明翰大学医学院，获生理学博士学位。2003回国受聘为南开大学医学院教授，创建神经生理实验室，从事生理学教学和科研工作。目前是中国生物物理学会理事会理事，天津神经科学学会理事，中华医学研究杂志专家编辑委员会常务编委，中华临床医学杂志英文版编委，天津医药杂志编委及英文编辑。每年招收1-2名硕士生及博士生。作为项目负责人目前主持2项国家自然科学基金面上项目、1项天津市自然科学基金重点项目。实验室的研究方向主要围绕神经系统重大疾病，通过相关的动物模型，进行行为学、神经电生理、免疫组化及神经元突触传递的机制研究，纳米材料在中枢神经系统的作用及其机制研究以及肾发育有关的离子通道机制研究。
近期论文
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LiZhigui,HaoShuang,YinHongqiang,GaoJing,YangZhuo.AutophagyamelioratescognitiveimpairmentthroughactivationofPVT1andapoptosisindiabetesmice.BehaviouralBrainResearch.2016;305:265–277
LuXiao,ChunhuaLiu,XiaoniaoChen,ZhuoYang.Zincoxidenanoparticlesinducerenaltoxicitythroughreactiveoxygenspecies.FoodandChemicalToxicology.2016;90:76–83
WenLi，Yuen-KiCheong，HuiWang，GuogangRen，ZhuoYang.Neuroprotectiveeffectsofetidronateand2,3,3-trisphosphonateagainstglutamate-inducedtoxicityinPC12cells.NeurochemRes.2015;41:844-854
JiajiaYang,ChunxiaoYang,ChunhuaLiu,TaoZhang,andZhuoYang,ParadoxicalEffectsofVEGFonSynapticActivityPartiallyInvolvedinNotch1SignalingintheMouseHippocampus.HIPPOCAMPUS26:589–600(2016)
WeiMiaomiao,LiuChunhua,ZhangXiaochen,ChenXiaoniao,LinHongliandYangZhuo.AutophagyisinvolvedinregulatingVEGFduringhigh-glucose-inducedpodocyteinjury.Mol.BioSyst.,2016,12,2202—2212
ChunhuaLiu,XiaxiaXu,JingGao,TaoZhang,ZhuoYang.HydrogensulfidepreventssynapticplasticityfromVD-induceddamageviaAkt/GSK-3βpathwayandNotchsignalingpathwayinrats.MolecularNeurobiology,2016;(53):4159–4172
XiaochenZhang,WenLi,ZhuoYang.Toxicologyofnanosizedtitaniumdioxide:anupdate.ArchToxico,2015;Volume89(12):2207–2217
ChunhuaLiu,HongqiangYin,JingGao,XiaxiaXu,TaoZhang,ZhuoYang.Leonurineamelioratescognitivedysfunctionviaantagonizingexcitotoxicglutamateinsultsandinhibitingautophagy.Phytomedicine,2016:1638-1646
NaGao,HuiWang,XiaochenZhang&ZhuoYang.TheinhibitoryeffectofangiotensinIIonBKCachannelsinpodocytesviaoxidativestress.MolCellBiochem(2015)398:217–222
XuanQin,YeLiu,MinghuiZhu,ZhuoYang,ThepossiblerelationshipbetweenexpressionsofTRPC3/5channelsandcognitivechangesinratmodelofchronicunpredictablestress.BehaviouralBrainResearch,2015;290:180–186
ZhiguiLi,LifengWang,JingXu&ZhuoYang.MiRNAexpressionprofileandmiRNA–mRNAintegratedanalysis(MMIA)duringpodocytedifferentiation.MolecularGeneticsandGenomics.MolGenetGenomics,2015;290:863–875
PengjuanXu,ZhiguiLi,QinjunXuan,ZhuoYang.Differentexpressionsoflarge-conductanceCa2+-activatedK+channelsinmouserenalcortexandhippocampusduringpostnataldevelopment.AppliedImmunohistochemistry&MolecularMorphology:2015;23(2):146-52
YeLiu,ChunhuaLiu,XuanQin,MinghuiZhu,ZhuoYang.Thechangeofspatialcognitionabilityindepressionratmodelandthepossibleassociationwithdown-regulatedproteinexpressionofTRPC6.BehaviouralBrainResearch,2015;294:186–193
JingGao,XiaochenZhang,MeiYu,GuogangRen,ZhuoYang.Cognitivedeficitsinducedbymulti-walledcarbonnanotubesviatheautophagicpathway.Toxicology337(2015):21–29
XiaochenZhang,WenLi&ZhuoYang.Toxicologyofnanosizedtitaniumdioxide:anupdate.ArchivesofToxicology.2015;89:2207–2217
MinghuiZhu,ChunhuaLiu,XuanQin,ZhuoYang.HyperforinalleviatesmooddeficitsofadultratssufferedfromearlyseparationNeuroscienceLetters.608(2015):1–5
WeiMiaomiao,LiZhigui,XiaoLu,YangZhuo*.EffectsofROS-relativeNF-κBsignalingonhighglucose-inducedTLR4andMCP-1expressioninpodocyteinjury.MolecularImmunology,2015;68:261–271
ZhaoweiLiu,JiajiaYang,XiaochenZhang,PengjuanXu,TaoZhang,ZhuoYang.
DevelopmentalChangesintheExpressionandFunctionofTRPC6ChannelsRelatedtheF-actinOrganizationduringDifferentiationinPodocytes.CellCalcium,2015;58:541–548
ChunhuaLiu,YeLiu,ZhuoYang.Myocardialinfarctioninducescognitiveimpairmentbyincreasingtheproductionofhydrogenperoxideinadultrathippocampus.NeuroscienceLetters.2014;(560):112-116
LiuZhaowei,XieYongling,YangJiajia&YangZhuo.ThereductionofEPSCamplitudeinCA1pyramidalneuronsbytheperoxynitritedonorSIN-1requiresCa2+influxViapostsynapticnon-L-typevoltagegatedcalciumchannels.NeurochemRes.2014;39:361-371
ZhangJunsi,LiYanna,XuJing,YangZhuo.TheroleofN-methyl-D-aspartatereceptorinAlzheimer'sdisease.JournaloftheNeurologicalSciences.2014;339:123-129
XuLanju,XuJing,LiuShichang,YangZhuo,InductionofapoptosisbyantimycinAindifferentiatedPC12cellline.JournalofAppliedToxicology.2014;651–657
MiaomiaoWei,ZhiguiLi,ZhuoYang.CrosstalkbetweenprotectiveautophagyandNF-κBsignalinhighglucose-inducedpodocytes.MolecularandCellularBiochemistry.2014;394(1-2):261-273
WeiweiDai,JiajiaYang,TingChen,ZhuoYang.ProtectiveEffectsofBexaroteneagainstAβ25-35-InducedDysfunctioninHippocampalNeuronsthroughInsulinSignalingPathway.NeurodegenerativeDiseases.2014;14(2):77-84
PengjuanXu,ZhiguiLi,XiaochenZhang,ZhuoYang.Increasedresponsetooxidativestresschallengeofnano-copper-inducedapoptosisinmesangialcells.JournalofNanoparticleResearch,2014;16(12):2777,1-13
ZhiguiLi,JingXu,PengjuanXu,ShichangLiu,ZhuoYang.Wnt/β-cateninsignalingpathwaymediateshighglucoseinducedcellinjurythroughactivationofTRPC6inpodocytes.CellProlif.,2013,46,76–85
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