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研究领域

科研方面目前主要从事中草药有效成分的提取分离及结构鉴定、中药质量标准化、指纹图谱、化学对照品以及中药新药开发等方面的研究工作。

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[1] Jing Li1, Xin-Lin Wu1, Yuling Chen, Zhi Tang, Yue-Hong Xu, Jian-Min Jiang, Yue-Yu Gu, Jian-Ping Chen, De-Po Yang, Dongmei Wang*. Anti-diarrheal Properties of Different Extracts of Chinese Herbal Medicine Formula Bao-Xie-Ning. CHIN J Integr Med. DOI: 10.3736/jintegrmed2013019. [2] Xiong Tan, Daomei Tan, Leslie Brown, Depo Yang, Longping Zhu, Yuling Chen, Dennis Hsu-tung Chang4, Dongmei Wang*. Isolation and purification of four bioactive constituents from Alpinia officinarum Hance utilizing high-speed counter-current chromatography. Journal of Liquid Chromatography& Related Technologies, DOI:10.1080/10826076.2012.691436 [3] 叶琼仙,谭雄,朱龙平,赵志敏,杨得坡,尹胜,王冬梅*,高良姜中二苯基庚烷类化合物的高速逆流色谱分离制备,色谱,2012,30(3):327-331。 [4] Zhi-Yu Wang, Tjing Yung Loo, Jian-Gang Shen, Neng Wang, Dong-Mei Wang, De-Po Yang, Sui-Lin Mo, Xin-Yuan Guan and Jian-Ping Chen. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. Breast Cancer Res Treat, 2012, 131: 791–800. (IF 4.859, 2010) [5] 梁镇然,蔡锐燕,蒋林,赵志敏,杨得坡,朱龙平,王冬梅*. 高速逆流色谱与硅胶柱层析联用分离岩黄连中的2种原小檗碱型季胺生物碱,分析实验室,2012,31(1):98-101。 [6] Qing-Hua Han1, Dong-Mei Wang1, Zhong-Bin Cheng, Xue Yang, Xin-Jun Xu, Jun Wang, Sheng Yin*, Chemical constituents from the leaves and twigs of Syzygium tetragonum Wall, Biochemical Systematics and Ecology, 2012, 41: 3-5. (IF 1.110, 2010)。 [7] Wang zhiyu, Cheng Yue, Wang Neng, Wang Dong Mei, Li Ying Wei, Han Feng, Shen Jian Gang, Yang De Po, Guan Xin Yuan, and Chen Jian-Ping. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins, Cancer Biology & Therapy, 2012, 13(3): 138-147. (IF 2.907, 2010) [8] ZhiYu Wang, Wings TY Loo, Neng Wang, Louis WC Chow, Dongmei Wang, Feng Han, Xiao Zheng & Jian-Ping Chen. Effect of Sanguisorba officinalis L on breast cancer growth and angiogenesis. Expert Opin. Ther. Targets, 2012, 16(Supplement 1), S79-S89. (IF 3.649, 2011) [9] Neng Wang, Zhi-Yu Wang, Sui-Lin Mo, Tjing Yung Loo, Dong-Mei Wang, Hai-Bin Luo, De-Po Yang, Yu-Ling Chen, Jian-Gang Shen, Jian-Ping Chen*. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Research and Treatment, 2012, 134(3), pp 943-955. (IF 4.431, 2011) [10] Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP*. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. Journal of Ethnopharmacology, 2011, 133(2): 751-758. (IF 2.322) [11] Jin-Yun Liu, Zhong Liu, Dong-Mei Wang, Man-Mei Li, Shao-Xiang Wang, Rui Wang, Jian-Ping Chen, Yi-Fei Wang, De-Po Yang, Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chemico-Biological Interactions, 2011, 190: 91–101. (IF 2.457, 2010) [12] 程悦,符影,王志宇,杨得坡,陈建萍*,王冬梅*. 鸡血藤提取物中缩合鞣质的含量测定及其抗肿瘤活性初步研究,中山大学学报(自然科学版),2011,50(2): 75-80。 [13] 曾凡力,程悦,陈建萍,符影,王巧利,杨得坡,陈振平,向阳飞,王一飞*,王冬梅*,鸡血藤醇提物体外抗病毒活性研究,中药新药与临床药理,2011, 22(1): 16-20。 [14] Dongmei Wang, Jie Bai, Feng Sun, Depo Yang*. Chemical constituents and antidepressant activity of a new species Hypericum enshiense occurring in China, Phytomedicine, 2010, 17(6): 410-413.(IF 2.174, 2009) [15] Jia-jie Zhai, Zhao-liang Liu, Jie-mei Li, Jian-Ping Chen, Lin Jiang, Dong-mei Wang, Jin Yuan, Jian-Gang Shen, De-Po Yang,* Jia-Qi Chen*, Different mechanisms of cis-9,trans-11- and trans-10,cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells, Journal of Nutritional Biochemistry, 2010, 21(11): 1099-1105. (IF 4.538, 2010) [16] Xiujuan Wang, Dongmei Wang, Jiaxian Li, Chuangxing Ye, and Kikue Kubota*. Aroma characteristics of Cocoa Tea (Camellia ptilophylla Chang), Biosci. Biotechnol. Biochem., 2010, 74(5): 946-953. (IF 1.326, 2009) [17] Dongmei Wang , Jie Bai, George Q Li and Depo Yang*, Effects of Hydroalcoholic Extracts of Four Chinese Hypericum Species on Learning and Memory in Mice, in “Comprehensive Bioactive Natural Products Vol. 3: Efficacy, Safety & Clinical Evaluation (part II)”, ed. by V.K. Gupta, pp. 95-104, 2010, Studium Press LLC, USA. ISBN 1-933699-53-1 (约1.5万字符) [18] Depo Yang, Jie Bai, Zhen Li, George Q Li and Dongmei Wang*, Antidepressant Activity of the Extracts of Three Hypericum species Native to China, in “Comprehensive Bioactive Natural Products Vol. 2: Efficacy, Safety & Clinical Evaluation (part I)”, ed. by V.K. Gupta, pp. 239-249, 2010, Studium Press LLC, USA. ISBN 1-933699-52-3 (约1.7万字符) [19] 王冬梅*,卢嘉丽,程悦,石祥刚,宋晓虹,叶创兴,苦茶的急性毒性与神经药理活性初步研究, 中山大学学报(自然科学版),2010, 49 (1): 76-79。 [20] 黄妙玲,杨得坡,梁祈,梅家齐,王冬梅*,顶空液相微萃取法与水蒸气蒸馏法提取金盏花挥发性成分的比较研究,中山大学学报(自然科学版),2010, 49(1): 145-148。

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