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研究领域

主要研究内皮源性一氧化氮(Endothelium-derived Nitric Oxide)、内皮源性收缩因子(Endothelium-derived contracting factor)及内皮源性超极化因子(Endothelium-derived hyperpolarizing factor)对血管平滑肌舒缩的调控;研究高血压、糖尿病、动脉粥样硬化等疾病中出现的血管内皮细胞功能障碍,探求防治血管内皮功能障碍的药物和靶点;研究血管内皮细胞衰老(Endothelial senescence)、线粒体功能障碍(Endothelial mitochondrial dysfunction)的分子机制;具有心血管活性的药物、天然产物的活性筛选及药效学研究。

近期论文

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(1) Zhuoming Li, Yu Wang, Ricky Y.K. Man, Paul M. Vanhoutte. Up-regulation of heme oxygenase-1 potentiates EDH-mediated relaxations in the mesenteric artery of the spontaneously hypertensive rat. (Under Revision) (2) Zhuoming Li, Yu Wang, Paul M. Vanhoutte. (2011) Up-regulation of Heme oxygenase-1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension. 58:926–934. (3) Zhuoming Li, Yu Wang, Paul M. Vanhoutte. (2011) Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat. Basic Clin Pharmacol Toxicol. 109(1):47-55. (4) Winnie Zhuoming Li, Jun Li, Cathy Wenchuan Bi, Anna W. Cheung, Wen Huang, Ran Duan, Roy C. Choi, Ivy S. Chen, Kuijun Zhao, Tina T. Dong, Jinao Duan, Karl W. Tsim. (2009) Can Rhizoma Chuanxiong replace Radix Angelica sinensis in the traditional Chinese herbal decoction Danggui Buxue Tang? Planta Medica. 75(6):602-6. (5) Jun Li, Winnie Zhuoming Li, Wen Huang, Anna W. Cheung, Cathy Wenchuan Bi, Ran Duan, Ava Jiangyang Guo, Tina T. Dong, Karl W. Tsim. (2009) Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. Journal of Chromatography A. 1216(11):2071-8. (6) 赵奎君,李卓明,陈小莺,董婷霞,詹华强. 从当归补血汤的研究探讨和分析中药复方共煎的合理性. 世界科学技术—中医药现代化,2009,11(2):294-298. (7) 李卓明,黄雯,李明,林忠泽,苏子仁. 安神补脑液高效液相色谱指纹图谱的研究. 中国实验方剂学杂志,2008,14(2):18-20. (8) 陈长青,谢友良,李卓明,蒋东旭,赖小平. “白术-白芍”药对不同提取工艺对药效作用的影响. 中药新药与临床药理,2007,18(3):214-216. (9) 黄鸣清,李卓明,李湘力,谢友良,赵学军,苏子仁.复方配伍共煎对三七中皂苷类成分的影响研究.中国中药杂志,2007,32:(10) :909-912.

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