鲁桂 - 中山大学

个人简介

鲁桂，女，1971年7月生，教授，博士生导师。1993年和1996年分获浙江大学学士、硕士学位，2003年获香港理工大学有机化学博士学位。1996-2005年在浙江大学化学系工作，历任助教、讲师、副教授；2003-2004年香港理工大学博士后；2005-2006年德国Erlangen-Nürnberg大学洪堡学者。2006年10月起任教中山大学药学院，2007年入选教育部新世纪优秀人才支持计划。主要从事新型抗病毒、抗肿瘤药物的设计、合成和生物活性研究；药物及其中间体高效合成方法的研究；不对称催化反应和手性催化剂的设计合成。目前已在国内外核心专业期刊上发表学术论文40余篇，担任国际学术刊物Adv. Synth. Catal.，Org. Biomol. Chem.，Tetrahedron：Asymmetry等杂志审稿人。先后承担科技部对欧盟科技合作专项经费、广东省引进创新科研团队项目分课题、国家自然科学基金、教育部留学回国人员科研启动基金、第7届欧盟框架项目分课题等。

研究领域

主要从事新型抗病毒、抗肿瘤药物的设计、合成和生物活性研究；药物及其中间体高效合成方法的研究；不对称催化反应和手性催化剂的设计合成。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Weng, J.; Li, J.-M.; Li, F.-Q.; Xie, Z.-S.; Lu, G.* Asymmetric domino nitro-Michael/Horner- Wadsworth-Emmons reaction for disubstituted cyclohexenecarboxylate annulation: efficient synthesis of DPP-4 inhibitor ABT-341 and influenza neuraminidase inhibitors. Adv. Synth. Catal. 2012,354, 1961-1970. Weng, J.; Li, Y.-B.; Wang, R.-B.; Lu, G.* Organocatalytic Michael reaction of nitroenamine derivatives with aldehydes: short and efficient asymmetric synthesis of (-)-oseltamivir. ChemCatChem. 2012, 4, 1007-1012. Liang, D.-C.; Luo, R.-S.; Yin, L.-H.; Chan, A. S. C.; Lu, G.* A new synthetic route for axially chiral secondary amines with binaphthyl backbone and their applications in asymmetric Michael reaction of aldehydes to nitroalkenes. Org. Biomol. Chem. 2012, 10, 3071-3079. Weng, J.; Ai, H.-B.; Luo, R.-S.; Lu, G.* Asymmetric Michael reaction of aldehydes with nitroalkenes catalyzed by pyrrolidine-camphor derived organocatalysts bearing hydrogen-bond donors. Chirality, 2012, 24, 271-275. Guo, Z.-L.; Deng, Y.-Q.; Zhong, S.; Lu, G.* Enantioselective synthesis of (R)-salmeterol employing an asymmetric Henry reaction as the key step.Tetrahedron: Asymmetry, 2011, 22, 1395-1399. Guo, Z.-L.; Zhong, S.;* Li, Y.-B.; Lu, G.* Chiral 1,1’-binaphthylazepine derived amino alcohol catalyzed asymmetric Henry reaction. Tetrahedron: Asymmetry, 2011, 22, 238-245. Weng, J.; Li, Y.-B.; Wang, R.-B.; Li, F.-Q.; Liu, C.; Chan, A. S. C.; Lu, G.* A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate. J. Org. Chem. 2010, 75, 3125-3128. Lin, N.; Chen, M.-M.; Luo, R.-S.; Deng, Y.-Q.; Lu, G.* Indolinylmethanol catalyzed enantioselective Reformatsky reaction with ketones. Tetrahedron: Asymmetry, 2010, 23, 2816-2824. Zhang, Z.-W.; Lu, G.;* Chen, M.-M.; Lin, N.; Li, Y.-B.; Hayashi, T.; Chan, A. S. C.* Organocatalytic asymmetric Mannich-type reaction of N-sulfonylimines with isocyanoacetate leading to optically active 2-imidazoline-4-carboxylates. Tetrahedron: Asymmetry, 2010, 21, 1735-1721. Liu, C.; Guo, Z.-L.; Weng, J.; Lu, G.;* Chan, A. S. C. Chiral 1,1’-binaphthylazepine-derived amino alcohol catalyzed asymmetric aryl transfer reactions with boroxine as aryl source. Chirality, 2010, 22, 159-164. Luo, R.-S.; Weng, J.; Ai, H.-B.; Lu, G.;* Chan, A. S. C. Highly efficient asymmetric Michael reaction of aldehydes to nitroalkenes with diphenylperhydroindolinol silyl ethers as organocatalysts. Adv. Synth. Catal. 2009, 351, 2449-2459. Li, F.-Q.; Zhong, S.; Lu, G.;* Chan, A. S. C. Zinc-salen-catalyzed asymmetric alkynylation of alkyl acylsilanes. Adv. Synth. Catal. 2009, 351, 1955-1960. Ruan, J. W.; Lu, G.;* Xu, L. J.; Li, Y. M.; Chan, A. S. C.* Catalytic asymmetric alkynylation and arylation of aldehydes by an H8-Binaphthyl-based amino alcohol ligand. Adv. Synth. Catal. 2008, 350, 76-84. Lu, G.; Li, Y. M.; Li, X. S.; Chan, A. S. C.* Synthesis and application of new chiral catalysts for asymmetric alkynylation reactions. Coord. Chem. Rev. 2005, 249, 1736-1744. Lu, G.; Li, X. S.; Jia, X.; Chan, W. L.; Chan, A. S. C.* Enantioselective alkynylation of aromatic ketones catalyzed by chiral camphorsulfonamide ligands. Angew. Chem. Int. Ed. 2003, 42, 5057-5058. Li, X. S.; Lu, G.; Kwok, W. H.; Chan, A. S. C.* Highly enantioselective alkynylzinc addition to aromatic aldehydes catalyzed by self-assembled titanium catalysts. J. Am. Chem. Soc. 2002, 124, 12636-12637.