研究领域
主要从事有机化学、生物化学及药物化学学科领域的教学和科研工作。
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1. Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes,Chem. Commun.2014, DOI: 10.1039/C4CC05394J. (SCI 6.718)
2. Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids,Chem. Commun.2014,50, 6927 - 6930. (SCI 6.718)
3. Rutaecarpine Analogues Reduce Lipid Accumulation in Adipocytes via Inhibiting Adipogenesis/Lipogenesis with AMPK Activation and UPR Suppression,ACS Chem. Biol.2013,8, 2301-2311. (SCI 5.356)
4. Benzofuroquinoline Derivatives Had Remarkable Improvement of their Selectivity for Telomeric G-Quadruplex DNA over Duplex DNA upon Introduction of Peptidyl Group,Bioconjugate Chem.2012,23, 1821–1831.(SCI 4.821)
5. Development of A Universal Colorimetric Indicator for G-Quadruplex Structures by the Fusion of Thiazole Orange and Isaindigotone Skeleton,Anal. Chem.2012,84, 6288–6292.(SCI 5.825)
6. Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction withc-mycPromoter G-Quadruplex,J. Med. Chem.2011, 54, 5671-5679. (SCI 5.48)
7. Effective Detection and Separation Method for G-Quadruplex DNA Based on Its Specific Precipitation with Mg2+,Biomacromolecules,2010,11, 3384-3389. (SCI 5.788)
8. Turning off Transcription of the bcl-2 Gene by Stabilizing the bcl-2 Promoter Quadruplex with Quindoline Derivatives,J. Med. Chem.2010,53, 4390-4398.(SCI 5.48)
9. Isaindigotone derivatives: A new class of highly selective ligands for telomeric G-quadruplex DNA,J. Med. Chem.2009,52, 2825-2835. (SCI 5.48)
10. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation,J. Med. Chem.2008,51, 6381-6392. (SCI 5.48)
11. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives,J. Med. Chem.2007,50, 1465-1474. (SCI 5.48)
12. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines,Oncogene2006, 25, 503-511. (SCI 8.559)
13. Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase,J. Med. Chem.2005,48, 7315-7321. (SCI 5.48)
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