林海燕 - 中国科学院动物研究所 -

个人简介

林海燕，女，博士，副研究员。1997和2000年分别获北京师范大学学士和硕士学位。2005年获中国科学院动物研究所博士学位。2006年至2008年在加拿大不列颠哥伦比亚大学做博士后研究。主要从事胚胎着床和妊娠机制的研究工作，研究兴趣集中在母胎界面分子免疫调控机理，探索母胎免疫豁免的分子基础和复发流产的发病机制。先后主持国家优秀青年基金项目（2014）、国家自然科学基金青年科学基金和面上项目、中加国际合作与交流项目、中国科学院知识创新工程领域前沿项目等，国家重大科学研究计划研究骨干。迄今在MolAspectsMed、JClinEndocrinolMetab、JBiolChem等期刊发表论文50余篇，其中第一作者或通讯作者论文20篇。

研究领域

主要从事胚胎着床和妊娠机制的研究工作，研究兴趣集中在母胎界面分子免疫调控机理，探索母胎免疫豁免的分子基础和复发流产的发病机制。

近期论文

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ZhengR,LiY,SunH,LuX,SunBF,WangR,CuiL,ZhuC,LinHY*,WangH.DeepRNAsequencinganalysisofsyncytialization-relatedgenesduringBeWocellfusion.Reproduction,2016,Oct14.pii:REP-16-0343.[Epubaheadofprint] LuX,HeY,ZhuC,WangH,ChenS*,LinHY*.Twist1isinvolvedintrophoblastsyncytializationbyregulatingGCM1.Placenta,2016,39,45-54. CuiL,WangH,LuX,WangR,ZhengR,LiY,YangX,JiaWT,ZhaoY,WangY,WangH,WangYL,ZhuC,LinHY*,WangH*.EffectsofindividuallysilencedN-glycosylationsitesandnon-synonymoussingle-nucleotidepolymorphismsonthefusogenicfunctionofhumansyncytin-2.CellAdhesion&Migration,2016,10(1-2),39-55. LeiJH,YangXK,PengS,LiY,UnderhillC,ZhuC,LinHY*,WangH*,HammondGL*.Impactofcorticosteroid-bindingglobulindeficiencyonpregnancyandneonatalsex.JClinEndocrinolMetab,2015,100,1819-1827. ZhangQ,YuS,HuangX,TanY,ZhuC,WangY,WangH,LinHY,FuJ*,WangH*.NewinsightsintothefunctionofCullin3introphoblastinvasionandmigration.Reproduction,2015,150,139-149. LiY,ZhengR,WangR,LuX,ZhuC,LinHY,WangH,YuX*,FuJ*.Involvementofnephrininhumanplacentaltrophoblastsyncytialization.Reproduction,2015,149,339-346. ZhouZ,WangR,YangX,LuXY,ZhangQ,WangYL,WangH,ZhuC,LinHY*,WangH*.ThecAMP-responsiveelementbindingprotein(CREB)transcriptionfactorregulatesfurinexpressionduringhumantrophoblastsyncytialization.Placenta,2014,35,907-918. WangR,DangYL,ZhengR,LiY,LiW,LuX,WangLJ,ZhuC,LinHY*,WangH*.Livecellimagingofinvitrohumantrophoblastsyncytialization.BiolReprod,2014,90,117. ChangW,YangQ,ZhangH,LinHY,ZhouZ,LuX,ZhuC,XueLQ*,WangH*.Roleofplacenta-specificprotein1introphoblastinvasionandmigration.Reproduction,2014,148,343-352. LiW,LiuD,ChangW,LuXY,WangYL,WangH,ZhuC,LinHY,ZhangY,ZhouJ*,WangH*.RoleofIGF2BP3introphoblastcellinvasionandmigration.CellDeathDis,2014,5,e1025. ZhouZ,ZhangQ,LuXY,WangR,WangH,WangYL,ZhuC,LinHY*,WangH*.Theproproteinconvertasefurinisrequiredfortrophoblastsyncytialization.CellDeathDis,2013,4,e593. ZhangS#,LinHY#,KongS#,WangS,WangHongmei,WangHaibin*,ArmantDR*.Physiologicalandmoleculardeterminantsofembryoimplantation.MolAspectsMed,2013,34,939-980. ZhangQ,ChenQ,LuXY,ZhouZ,ZhangH,LinHY,DuanE,ZhuC,TanY*,WangH*.CUL1promotestrophoblastcellinvasionatthematernal-fetalinterface.CellDeathDis,2013,4,e502. YangX,WangQ,GaoZ,ZhouZ,PengS,ChangWL,LinHY,ZhangW*,WangH*.Proproteinconvertasefurinregulatesapoptosisandproliferationofgranulosacellsintheratovary.PLoSONE,2013,8,e50479. LinHY*,UnderhillC,LeiJH,Helander-ClaessonA,LeeHY,GardillBR,MullerYA,WangH*,HammondGL*.HighfrequencyofSERPINA6polymorphismsthatreduceplasmacorticosteroid-bindingglobulinactivityinChinesesubjects.JClinEndocrinolMetab,2012,97,E678-E686. ZhaoKQ,LinHY*,ZhuC,YangX,WangH*.MaternalSmad3deficiencycompromisesdecidualizationinmice.JCellBiochem,2012,113,3266-3275. LiY,WuL,LeiJH,ZhuC,WangH,YuXG*,LinHY*.Singlenucleotidepolymorphismsinthehumancorticosteroid-bindingglobulinpromoteraltertranscriptionalactivity.SciChinaLifeSci,2012,55,699-708. GardillBR,VoglMR,LinHY,HammondGL,MullerYA*.Corticosteroid-bindingglobulin:structure-functionimplicationsfromspeciesdifferences.PLoSONE,2012,7,e52759. WuL,ZhouHH,LinHY,QiJG,ZhuC,GaoZY*,WangH*.CirculatingmicroRNAsareelevatedinplasmafromseverepre-eclampticpregnancies.Reproduction,2012,143,389-397. YangXK,ZhouY,PengS,WuL,LinHY,WangSY*,WangH*.DifferentiallyexpressedplasmamicroRNAsinprematureovarianfailurepatientsandthepotentialregulatoryfunctionofmir-23aingranulosacellapoptosis.Reproduction,2012,144,235-244. LinHY*,MullerYA,HammondGL*.Molecularandstructuralbasisofsteroidhormonebindingandreleasefromcorticosteroid-bindingglobulin.MolCellEndocrinol,2010,316,3-12 FuJ,LvX,LinHY,WuL,WangR,ZhouZ,ZhangB,WangYL,TsangBK,ZhuC,WangH*.Ubiquitinligasecullin7inducesepithelial-mesenchymaltransitioninhumanchoriocarcinomacells.JBiolChem,2010,285,10870-10879. LinHY,UnderhillC,GardillBR,MullerYA,HammondGL*.Residuesinthehumancorticosteroid-bindingglobulinreactivecenterloopthatinfluencesteroidbindingbeforeandafterelastasecleavage.JBiolChem,2009,284,884-896. YangQ,ChenSP,ZhangXP,WangH,ZhuC,LinHY*.Smurf2participatesinhumantrophoblastcellinvasionbyinhibitingTGF-betatypeIreceptor.JHistochemCytochem,2009,57,605-612. ZhangB,ZhouZ,LinHY,LvX,FuJ,LinP,ZhuC,WangH*.Proteinphosphatase1A(PPM1A)isinvolvedinhumancytotrophoblastcellinvasionandmigration.HistochemCellBiol,2009,132,169-179. ZhouZ,ShenT,ZhangBH,LvXY,LinHY,ZhuC,XueLQ*,WangH*.Theproproteinconvertasefurininhumantrophoblast:Possibleroleinpromotingtrophoblastcellmigrationandinvasion.Placenta,2009,30,929-938. ZhangH,LinHY,YangQ,WangHX,ChaiKX,ChenLM,ZhuC*.Expressionofprostasinserineproteaseandproteasenexin-1(PN-1)inrhesusmonkeyovaryduringmenstrualcycleandearlypregnancy.JHistochemCytochem,2007,55,1237-1244. YangQ,LinHY,WangHX,ZhangH,ZhangXP,WangH,ZhuC*.Expressionofsmadubiquitinregulatoryfactor2(Smurf2)inrhesusmonkeyendometriumandplacentaduringearlypregnancy.JHistochemCytochem,2007,55,453-460. ZhangX,ZhuC,LinHY,YangQ,OuQ,LiY,ChenZ,RaceyP,ZhangS*,WangH*.Wildfulvousfruitbats(Rousettusleschenaulti)exhibithuman-likemenstrualcycle.BiolReprod,2007,77,358-364. ZhangH,LiQ,LinHY,YangQ,WangH,ZhuC*.RoleofPPARgammaanditsgonadotrophicregulationinratovariangranulosacellsinvitro.NeuroendocrinolLett,2007,28,289-294. LinHY,YangQ,WangH,QiJG,ZhangH,WangHX,TsangBK,ZhuC*.InvolvementofSMAD4,butnotofSMAD2,intransforminggrowthfactor-β1-inducedtrophoblastexpressionofmatrixmetalloproteinase-2.FrontBiosci,2006,11,637-646. LinHY,ZhangH,YangQ,WangHX,WangH,ChaiKX,ChenLM*,ZhuC*.Expressionofprostasinandproteasenexin-1inrhesusmonkey(Macacamulatta)endometriumandplacentaduringearlypregnancy.JHistochemCytochem,2006,54,1139-1147. LinHY,QianD,ZhangX,LiuGY,WangH,ZhuC*.Geneexpressionoftransforminggrowthfactor-βreceptorstypesIandIIinratendometriumduringtheestrouscycleandearlypregnancy.LifeSci,2006,78,2669-2675. WangHX,WangH,LinHY,YangQ,ZhangH,TsangBK,ZhuC*.ProteasomesubunitLMP2isrequiredformatrixmetalloproteinase-2and-9expressionandactivitiesinhumaninvasiveextravilloustrophoblastcellline.JCellPhysiol,2006,206,616-623. LiuGY,ZhangX,LinHY,WangH,LiQL,NiJ,ZhuC*.EffectsofE-cadherinonmouseembryoimplantationandexpressionofmatrixmetalloproteinase-2and-9.BiochemBiophysResCommun,2006,343,832-838. YangQ,WangHX,ZhaoYG,LinHY,ZhangH,WangH,SangQA,ZhuC*.Expressionoftissueinhibitorofmetalloproteinase-4(TIMP-4)inendometriumandplacentaofrhesusmonkey(Macacamulatta)duringearlypregnancy.LifeSci,2006,78,2804-2811. ZhangX,LinHY,LiuGY,WangH,LiQL,ZhuC*.Expressionsandregulationofendothelialandinduciblenitricoxidesynthasesinmouseuterusduringtheestrouscycleandearlypregnancy.FrontBiosci,2005,10,3172-3182. WangHX,ZhaoYG,WangH,YangQ,LinHY,SangQA,ZhuC*.Expressionofadamalysin19/ADAM19intheendometriumandplacentaofrhesusmonkey(Macacamulatta)duringearlypregnancy.MolHumReprod,2005,11,429-435. LinHY,WangH,LiQL,LiuDL,ZhangX,LiuGY,QianD,ZhuC*.ExpressionofSmad2andSmad4,transforminggrowthfactor-βsignaltransducers,inratendometriumduringtheestrouscycle,pre-,andperi-implantation.AnimReprodSci,2004,80,303-316. QianD,LinHY,WangH,ZhangX,LiuDL,LiQL,ZhuC*.Normoxicinductionofthehypoxic-induciblefactor-1αbyinterleukin-1βinvolvestheextracellularsignal-regulatedkinase1/2pathwayinnormalhumancytotrophoblastcells.BiolReprod,2004,70,1822-1827. LiuG,LinHY,ZhangX,LiQ,WangH,QianD,NiJ,ZhuC*.ExpressionofSmad2andSmad4inmouseuterusduringtheestrouscycleandearlypregnancy.Placenta,2004,25,530-537. QianD,LinHY,WangH,ZhangX,LiQL,LiuDL,ZhuC*.InvolvementofERK1/2pathwayinTGF-β1-inducedVEGFsecretioninnormalhumancytotrophoblastcells.MolReprodDev,2004,68,198-204. ZhangX,WangH,LinHY,LiuGY,LiQL,ZhuC*.Regulationofmatrixmetalloproteinases(MMPs)andtheirinhibitors(TIMPs)duringmouseperi-implantation:roleofnitricoxide.Placenta,2004,25,243-252. WangH,ZhangX,QianD,LinHY,LiQL,LiuDL,LiuGY,YuXD,ZhuC*.Effectofubiquitin-proteasomepathwayonmouseblastocystimplantationandexpressionofmatrixmetalloproteinases-2and-9.BiolReprod,2004,70,481-487. WangHX,WangH,LiQL,LinHY,QianD,ZhuC*.ExpressionofproteasomesubunitsLMP2andLMP7intheendometriumandplacentaofrhesusmonkey(Macacamulatta)duringearlypregnancy.BiolReprod,2004,71,1317-1324. LinHY,WangH,ZhuC*.TheSmadpathwayintransforminggrowthfactor-betasignaling.SciChinaCLifeSci,2003,46,449-463. WangH,LiQL,LinHY,YuXD,QianD,DaiJJ,DuanEK,ZhuC*.Expressionofvascularendothelialgrowthfactoranditsreceptorsintherhesusmonkey(Macacamulatta)endometriumandplacentaduringearlypregnancy.MolReprodDev,2003,65,123-131. QianD,WangH,LinHY,ZhangX,LiQL,LiuDL,LiuGY,ZhuC*.EffectofUPPontheexpressionofVEGFanditsreceptorsinmouseuterusduringperi-implantation.ChinSciBull,2003,48,338-342. LiQL,WangH,LinHY,ZhuC*.Expressionofgelatinasesandtheirtissueinhibitorsinratcorpusluteumduringpregnancyandpostpartum.MolReprodDev,2002,63,273-281. LiuDL,LiQL,LinHY,LiuWZ,WangH,ZhangX,ZhuC*.ExpressionandlocalizationofRAP250mRNAintheratovary:Possibleimplicationsinfolliculardevelopmentandovulation.Endocrine,2002,18,173-178. LiQL,WangH,LinHY,ShaoLJ,NiJ,DuanEK,ZhuC*.ExpressionofVEGFinthepregnantandpostpartrumratovaries.SciChinaCLifeSci,2002,45,379-387. ZhangX,WangH,LinHY,LiQL,LiuDL,QianD,LiuGY,ZhuC*.Regulationofblastocystimplantationbynitricoxideinmouse.ChinSciBul,2002,47,1461-1465. LiQL,WangH,ZhaoYG,LinHY,SangQA,ZhuC*.Identificationandspecificexpressionofendometase/matrilysin-2(MMP-26)inendometriumofrhesusmonkeyduringearlypregnancy.MolHumReprod,2002,8,934-940.