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个人简介

韩之明,女,博士,副研究员。 1996年毕业于北京师范大学生物学专业,获理学学士学位。1996至1997年在中国科学院动物研究所生殖生物学国家重点实验室受精生物学研究组工作,1997至2002年为北京师范大学生命科学学院硕博连读研究生,主要在中国科学院动物研究所从事动物克隆的研究,参与了中国科学院知识创新和科技部攀登项目“异种克隆大熊猫研究”,国家自然科学基金“体细胞克隆牛研究”,“973”课题“异种克隆中线粒体命运研究”以及“治疗性克隆灵长类动物模型的建立”等课题的研究工作。2002年7月于北京师范大学获理学博士学位。2002年12月赴美国坦普尔大学医学院费尔斯肿瘤与分子生物学研究所从事博士后研究工作,研究方向为动物克隆及胚胎发育机理,参与了“小鼠克隆的表观遗传学研究”,“克隆胚胎的核重编程研究”及“着床前胚胎的卵裂球胞质碎片化研究”等多项美国国立卫生研究院课题的研究工作。2007年12月任中国科学院动物研究所副研究员,主要从事哺乳动物受精、克隆和早期胚胎发育的研究。现承担国家自然科学基金面上项目、国家高技术研究发展计划(863项目)课题以及中国科学院动物研究所青年科技创新人才资助项目。已在BiologyofReproduction,MolecularReproductionandDevelopment,DevelopmentalBiology,Genetics,TrendsinBiotechnology,MolecularBiologyoftheCell等学术期刊上发表学术论文53篇,其中SCI文章共计43篇,已被引用200余次。

研究领域

从事受精机理的研究。

近期论文

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HanZ,LiangCG,ChengY,DuanX,ZhongZ,PotireddyS,MoncadaC,MeraliS,LathamKE.2010.OocyteSpindleProteomicsAnalysisLeadingtoRescueofChromosomeCongressionDefectsinClonedEmbryos.JProteomeRes.9(11):6025-6032. HanZ,ChengY,LiangCG,LathamKE.2010.Nucleartransferinmouseoocytesandembryos.MethodsEnzymol.476:171-184. HanZ,MtangoNR,ZhongZ,VassenaR,LathamKE.2010.Earlytranscriptionfromthematernalgenomecontrollingblastomereintegrityinmousetwo-cell-stageembryos.AmJPhysiolCellPhysiol.298(5):C1235-1244. HanZ,MtangoNR,PatelBG,SapienzaC,LathamKE.2008.HybridVigorandTransgenerationalEpigeneticEffectsonEarlyMouseEmbryoPhenotype.BiologyofReproduction.79(4):638-648. HanZ,VassenaR,ChiMM,PotireddyS,SutovskyM,MoleyKH,SutovskyP,LathamKE.2008.Roleofglucoseinclonedmouseembryodevelopment.AmJPhysiolEndocrinolMetab.295(4):E798-809. LiangCG,HanZ,ChengY,ZhongZ,LathamKE.2009.Effectsofooplasmtransferonpaternalgenomefunctioninmice.HumReprod.24(11):2718-2728 WangJ,ZhangM,ZhangY,KouZ,HanZ,ChenDY,SunQY,GaoS.2009.TheHistoneDemethylaseJMJD2CIsStage-SpecificallyExpressedinPreimplantationMouseEmbryosandIsRequiredforEmbryonicDevelopment.BiolReprod.82(1):105-111. ShiLH,AiJS,OuyangYC,HuangJC,LeiZL,WangQ,YinS,HanZM,SunQY,ChenDY.2008.TrichostatinAandnuclearreprogrammingofclonedrabbitembryos.Journalofanimalscience86(5):1106-1113. ShiLH,MiaoYL,OuyangYC,HuangJC,LeiZL,YangJW,HanZM,SongXF,SunQY,ChenDY.2008.TrichostatinA(TSA)improvesthedevelopmentofrabbit-rabbitintraspeciesclonedembryos,butnotrabbit-humaninterspeciesclonedembryos.DevelopmentalDynamics.237(3):640-648. HanZ,VandevoortCA,LathamKE.2007.Therapeuticcloning:statusandprospects.Currentopinioninmoleculartherapeutics.9(4):392-397. VassenaR,HanZ,GaoS,LathamKE.2007.Deficiencyinrecapitulationofstage-specificembryonicgenetranscriptionintwo-cellstageclonedmouseembryos.MolecularReproductionandDevelopment.74(12):1548-1556. KuzminA,HanZ,GoldingMC,MannMR,LathamKE,VarmuzaS.2008.ThePcGgeneSfmbt2ispaternallyexpressedinextraembryonictissues.GeneExpressPatterns.8(2):107-116. HaoL,VassenaR,WuG,HanZ,ChengY,LathamKE,SapienzaC.2009.TheunfoldedproteinresponsecontributestopreimplantationmouseembryodeathintheDDKsyndrome.BiolReprod.80(5):944-953. ChengY,WangK,KellamLD,LeeYS,LiangCG,HanZ,MtangoNR,LathamKE.2009.EffectsofOoplasmManipulationonDNAMethylationandGrowthofProgenyinmice.BiologyofReproduction.80(3):464-472. VassenaR,HanZ,GaoS,BaldwinDA,SchultzRM,LathamKE.2007.Toughbeginnings:alterationsinthetranscriptomeofclonedembryosduringthefirsttwocellcycles.DevelopmentalBiology.304(1):75-89. LathamKE,GaoS,HanZ.2007.Somaticcellnucleiincloning:strangerstravelinginaforeignland.Advancesinexperimentalmedicineandbiology.591:14-29. MiyaraF,HanZ,GaoS,VassenaR,LathamKE.2006.Non-equivalenceofembryonicandsomaticcellnucleiaffectingspindlecompositioninclones.DevelopmentalBiology.289(1):206-217. HanZ,ChungYG,GaoS,LathamKE.2005.Maternalfactorcontrollingblastomerefragmentationinearlymouseembryos.BiologyofReproduction.72(3):612-618. GaoS,WuG,HanZ,delaCasaE,SapienzaC,LathamKE.2005.RecapitulationoftheOvummutant(Om)phenotypeandlossofOmlocuspolarityinclonedmouseembryos.BiologyofReproduction.72(2):487-491. NolanL,GaoS,HanZ,ChungYG,BartolomeiM,LathamKE.2005.AberrantXchromosomeregulationinclonedmice.DevelopmentalBiology.279(2):525-540. WuG,HaoL,HanZ,GaoS,LathamKE,Pardo-ManueldeVillenaF,SapienzaC.2005.MaternaltransmissionratiodistortionatthemouseOmlocusresultsfrommeioticdriveatthesecondmeioticdivision.Genetics.170:327-334. BeckerM,BeckerA,MiyaraF,HanZ,KiharaM,BrownDT,HagerGL,LathamK,AdashiEY,MisteliT.2005.Differentialinvivobindingdynamicsofsomaticandoocyte-specificlinkerhistonesinoocytesandduringEScellnucleartransfer.MolecularBiologyoftheCell.16(8):3887-3895. GaoS,HanZ,KiharaM,AdashiE,LathamKE.2005.EffectsofproteaseinhibitorMG132onnuclearreprogramminginclonedmouseembryos.TrendsinBiotechnology.23(2):66-68. GaoS,CzirrE,ChungYG,HanZ,LathamKE.2004.Geneticvariationinoocytephenotyperevealedthroughparthenogenesisandcloning:correlationwithdifferencesinpronuclearepigeneticmodification.BiologyofReproduction.70(4):1162-1170. HanZM,ChenDY,LiJS,SunQY,WanQH,KouZH,RaoG,LeiL,LiuZH,FangSG.2004.MitochondrialDNAheteroplasmyincalvesclonedbyusingadultsomaticcell.MolecularReproductionandDevelopment.67(2):207-214. HanZM,ChenDY,LiJS,SunQY,WangPY,DuJ,ZhangHM.2003.Flowcytometriccell-cycleanalysisofculturedfibroblastsfromthegiantpanda,AiluropodamelanoleucaL.CellBiologyInternational.27(4):349-353. YangCX,HanZM,WenDC,SunQY,ZhangKY,ZhangLS,WuYQ,KouZH,ChenDY.2003.Invitrodevelopmentandmitochondrialfateofmacaca-rabbitclonedembryos.MolecularReproductionandDevelopment.65(4):396-401. ZhuZY,ChenDY,LiJS,LianL,LeiL,HanZM,SunQY.2003.Rotationofmeioticspindleiscontrolledbymicrofilamentsinmouseoocytes.BiologyofReproduction.68(3):943-946. ZhuZY,WenDC,HanZM,LeiL,LiuZH,KouZH,XuY,WangMK,ChenDY.2003.Thedynamicsandfunctionsofcytoskeletonduringmeioticresumptioninducedbyparthenogeneticactivationinmouseoocytes.ProgressinBiochemistryandBiophysics.30(5):819-823. ChenDY,LiJS,HanZM,LeiL,LiuZH,KouZH,MaSY,DuQK,SunQY.2003.Somaticcellbovinecloning:Effectofdonorcellandrecipients.ChineseScienceBulletin.48(6):549-554.[陈大元,李劲松,韩之明,雷蕾,刘忠华,寇朝辉,马世援,杜启科,孙青原.2003.体细胞克隆牛:供体细胞和受体的影响.科学通报.48(8):768-773.]

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