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个人简介

李向东,男,博士,研究员,博士生导师;现为中国科学院动物研究所细胞运动与肌肉收缩研究组组长,兼任农业虫害鼠害综合治理研究国家重点实验室副主任。1990年华东化工学院生物化学专业学士毕业,1993年中国科学院上海昆虫研究所硕士毕业,1996年中国科学院上海生物化学研究所博士毕业,1996-2009年在美国马萨诸塞大学医学院从事研究工作,先后担任博士后,讲师和研究助理教授。2009年入选中国科学院百人计划,担任中国科学院动物研究所研究员,主要从事细胞内物质转运的分子机制研究及无脊椎动物肌肉系统发育调节研究。近年来取得的研究成果主要发表于国际核心学术期刊,包括PNAS,J.Biol.Chem.,Biochemistry,InsectMolecularBiology等。获奖及荣誉: 中国科学院百人计划(2009-2011) AmericanHeartAssociationPostdoctoralFellowship(1999–2001) 承担科研项目情况: 国家自然科学基金面上项目(31672359)可变剪切部位调节飞蝗横纹肌肌球蛋白马达功能的分子机制(2017.01-2020.12),项目负责人 国家自然科学基金面上项目(31470791)平滑肌肌球蛋白磷酸化调节的分子机理(2015.01-2018.12),项目负责人 国家重大科学研究计划973项目纳米生物机器的可控组装与多功能集成/课题二(2013CB932802)蛋白质纳米机器系统的功能集成研究(2013.01-2017.12),课题负责人 国家重点基础研究发展规划973项目害虫暴发成灾的遗传与行为机理/课题二(2012CB114102)害虫种群暴发的行为遗传机制(2012.01-2016.12),课题骨干 国家自然科学基金面上项目(31171367)非典型肌球蛋白V调节机理的研究(2012.01-2015.12),项目负责人 国家自然科学基金面上项目(31071973)昆虫特有肌球蛋白的功能与调节研究(2011.01-2013.12),项目负责人 中国科学院知识创新工程前沿领域项目(KSCX2-YW-N-072)昆虫肌肉收缩机理研究(2009.01-2011.12),项目负责人 AmericanHeartAssociation-ScientistDevelopmentGrant(0530211N),Regulationofmyosin-Va(2004.1-2008.12),项目负责人

研究领域

研究领域: 研究方向有三个:1)肌肉系统的结构与收缩机理,侧重于研究无脊椎动物尤其是昆虫肌肉系统的发育与功能调节;2)细胞运动与细胞内物质转运,以细胞骨架及分子马达蛋白为核心,研究细胞运动与细胞内物质转运的分子机制;3)蛋白质分子马达在纳米机器中的应用,以蛋白质分子马达为核心,构建能够实现能量转换、物质转化及输运功能的人工纳米机器系统。

近期论文

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Qing-JuanCao#,NingZhang#,RuiZhou,Lin-LinYao,andXiang-dongLi*(2019)ThecargoadaptorproteinsRILPL2andmelanophilinco-regulatemyosin-5amotoractivity.JournalofBiologicalChemistry294(29):11333–11341. Huan-HongJi#,Lin-LinYao#,ChangLiu,andXiang-dongLi*(2019)RegulationofMyosin-5bbyRab11aandtheRab11familyinteractingprotein2.BioscienceReports39(1):BSR20181252. NingZhang#,Lin-LinYao#,andXiang-dongLi*(2018)RegulationofClassVMyosin.CellularandMolecularLifeScience75(2):261-273. Hai-ManZhang,Huan-HongJi,TongNi,Rong-NaMa,AibingWang,andXiang-dongLi*(2017)CharacterizationofBlebbistatinInhibitionofSmoothMuscleMyosinandNonmuscleMyosin-2.Biochemistry56(32):4235-4243. NingZhangandXiang-dongLi*(2017)DirectionalTransportationofAssembledMolecularLinearMotors,inSupramolecularChemistryofBiomimeticSystems(Li,J.,Ed.)SpringerNature,Singapore. MeiShen#,NingZhang#,SanduoZheng#,Wen-BoZhang,Hai-ManZhang,ZekuanLu,QianPeterSu,YujieSun,KeqiongYe,andXiang-dongLi*(2016)CalmodulinincomplexwiththefirstIQmotifofmyosin-5afunctionsasanintactcalciumsensor.ProceedingsoftheNationalAcademyofSciencesUSA113:E5812-E5820. JingLi,ZekuanLu,JingHe,QianquanChen,XianhuiWang,LeKang,andXiang-dongLi*(2016)AlternativeExon-encodingRegionsofLocustamigratoriaMuscleMyosinModulatethepHdependenceofATPaseActivity.InsectMolecularBiology25:689–700. NanChen,Yong-LiangFan*,YuBai,Xiang-dongLi,Zhan-FengZhang,andTong-XianLiu*(2016)CytochromeP450gene,CYP4G15,modulateshydrocarbonproductioninthepeaaphid,Acyrthosiphonpisum.InsectBiochemistryandMolecularBiology76:84-94. Wen-BoZhang,Lin-LinYao,andXiang-dongLi*(2016)TheGlobularTailDomainofMyosin-5aFunctionsAsaDimerinRegulatingtheMotorActivityJournalofBiologicalChemistry291:13571-13579. Lin-LinYao,MeiShen,ZekuanLu,MitsuoIkebe,andXiang-dongLi*(2016)Identificationoftheisoform-specificinteractionsbetweenthetailandtheheadofclassVmyosin.JournalofBiologicalChemistry291:8241-8250. HannaWitwick,HongJia,ArtemKutikov,PabloReyes-Gutierrez,Xiang-dongLi,PaulR.Odgren*(2015)TRAFD1(FLN29)InteractswithPlekhm1andRegulatesOsteoclastAcidificationandResorption.PLOSONE10:e0127537 ChengqiZhang#,YunChen#,YanniYin,Huan-HongJi,Won-BoShim,YipingHou,MingguoZhou*,Xiang-dongLi*,andZhonghuaMa*(2015)Asmallmoleculespecies-specificallyinhibitsFusariummyosinI.EnvironmentalMicrobiology17(8):2735–2746. Huan-HongJi,Hai-ManZhang,MeiShen,Lin-LinYao,Xiang-dongLi*(2015)ThemotorfunctionofDrosophilamelanogastermyosin-5isactivatedbycalciumandcargo-bindingproteindRab11.BiochemicalJournal469(1):135-144. Lin-LinYao#,Qing-JuanCao#,Hai-ManZhang#,JieZhang,YangCao,andXiang-dongLi*(2015)MelanophilinStimulatesMyosin-5aMotorFunctionbyAllostericallyInhibitingtheInteractionbetweentheHeadandTailofMyosin-5a.ScientificReports5:10874. ZekuanLu,Xiao-NanMa,Hai-ManZhang,Huan-HongJi,HaoDing,JieZhang,DanLuo,YujieSun,andXiang-dongLi*(2014)MouseMyosin-19isaPlus-end-directed,High-dutyRatioMolecularMotor.JournalofBiologicalChemistry289:18535–18548. YangCao,HowardD.White,andXiang-dongLi*(2014)Drosophilamyosin-xxfunctionsasanactin-bindingproteintofacilitatetheinteractionbetweenzyx102andactin.Biochemistry53,350–360. Rong-NaMa,KatsuhideMabuchi,JingLi,ZekuanLu,Chih-LuehAlbertWang,andXiang-dongLi*(2013)CooperationbetweentheTwoHeadsofSmoothMuscleMyosinIsEssentialforFullActivationoftheMotorFunctionbyPhosphorylation.Biochemistry52,6240?6248. ZekuanLu#,MeiShen#,YangCao,Hai-ManZhang,Lin-LinYao,Xiang-dongLi*(2012)CalmodulinboundtothefirstIQmotifisresponsibleforcalcium-dependentregulationofmyosin5a.JournalofBiologicalChemistry287:16530-16540(#,equalcontribution). 曹洋,沈梅,张洁,李向东*(2011)果蝇非常规肌球蛋白的结构与功能.应用昆虫学报48:239-246. NobuhisaUmeki,HyunSukJung,ShinyaWatanabe,TsuyoshiSakai,Xiang-dongLi,ReikoIkebe,RogerCraig,andMitsuoIkebe*(2009)Thetailbindstothehead-neckdomain,inhibitingATPaseactivityofmyosinVIIAProceedingsoftheNationalAcademyofSciencesUSA106:8483-8. Xiang-dongLi*,HyunSukJung,QizhiWang,ReikoIkebe,RogerCraig,andMitsuoIkebe(2008)TheglobulartaildomainputsonthebraketostoptheATPasecycleofthemyosinVa.ProceedingsoftheNationalAcademyofSciencesUSA105:1140-1145(Citiedin“Facultyof1000”). ZhipingWang,JeffreyG.Edwards,NathanRiley,D.WilliamProvance,Jr.,RyanKarcher,Xiang-dongLi,IanG.Davison,MitsuoIkebe,JohnA.Mercer,JulieA.Kauer,andMichaelD.Ehlers*(2008)MyosinVbmobilizesrecyclingendosomesandAMPAreceptorsforpostsynapticplasticity.Cell135,535-548. OsamuSato,Xiang-dongLi,andMitsuoIkebe*(2007)MyosinVabecomesalowdutyratiomotorintheinhibitedform.JournalofBiologicalChemistry282:13228-13239. Xiang-dongLi*,HyunSukJung,KatsuhideMabuchi,RogerCraig,andMitsuoIkebe(2006)TheglobulartaildomainofmyosinVafunctionsasaninhibitorofthemyosinVamotor.JournalofBiologicalChemistry281:21789-21798(Citiedin“Facultyof1000”). Xiang-dongLi,ReikoIkebe,andMitsuoIkebe*(2005)ActivationofMyosinVafunctionbymelanophilin,aspecificdockingpartnerofMyosinVa.JournalofBiologicalChemistry278:29435-29441. Xiang-dongLi,KatsuhideMabuchi,ReikoIkebe,andMitsuoIkebe*(2004)Ca2+inducedactivationofATPaseactivityofmyosinVaisaccompaniedwithalargeconformationalchange.BiochemicalandBiophysicalResearchCommunications315:538-545. Xiang-dongLiandMitsuoIkebe*(2003)Twofunctionalheadsarerequiredforfullactivationofsmoothmusclemyosin.JournalofBiologicalChemistry278:29435-29441. YuChen,NorioTakizawa,JessicaLCrowley,SangW.Oh,CherylL.Gatto,TaketoshiKambara,OsamuSato,Xiang-dongLi,MitsuoIkebe,andElizabethJ.Luna*(2003)F-actinandmyosinIIbindingdomainsinsupervillin.JournalofBiologicalChemistry278:46094-46106 XinZhou,Xiang-dongLi,Jian-zhongYuan,Zhen-huaTang,andWang-yiLi*(2000)ToxicityofCinnamomin-AnewtypeIIribosome-inactivatingproteintoballwormandmosquito.InsectBiochemistryandMolecularBiology30(3):259-264 Xiang-dongLi,JunyaSaito,ReikoIkebe,KatsuhideMabuchi,andMitsuoIkebe*(2000)Theinteractionbetweentheregulatorylightchaindomainsontwoheadsiscriticalforregulationofsmoothmusclemyosin.Biochemistry39(9):2254-2260. Xiang-dongLi,TroyE.Rhodes,ReikoIkebe,TaketoshiKambara,HowardD.WhiteandMitsuoIkebe*(1998)Effectsofmutationsintheg-phosphatebindingsiteofmyosinonitsmotorfunction.JournalofBiologicalChemistry273(42):27404-27411. Wang-yiLiu*,Huai-yangChen,Wen-fengChen,Xiang-dongLi,NorbertUlbrichandWernerSchroder(1997)Aproposedpositionofadisulfidebridgeinthemoleculesofcinnamominandporrectin-twonewtypeIIribosome-inactivatingproteinsisolatedfromtheseedsofcamphortrees.BiochemistryandMolecularBiologyInternational44(5):1045-1049. Xiang-dongLi,Wen-fengChen,Wang-yiLiu*,andGui-haiWang(1997)Large-scalepurificationoftwonewribosome-inactivatingproteins---cinnamominandcamphorinfromtheseedofCinnamomumcamphora.ProteinExpressionandPurification10:27-31. 李向东,刘望夷*(1997)核糖体失活蛋白研究进展。生命的化学17(2):15-18. 李向东,刘望夷*(1997)核糖体失活蛋白结构功能与分布。细胞生物学杂志19(2):69-75. Xiang-dongLi,Wang-yiLiu*,andChing-iNiu.(1996)Purificationofanewribosome-inactivatingproteinfromtheseedsofCinnamomumporrectumandcharacterizationoftheRNAN-glycosidaseactivityofthetoxicprotein.BiologicalChemistry,377:825-831. JunLing,Xiang-dongLi,Xiao-huaWu,andWang-yiLiu*(1995)TopologicalrequirementsforrecognitionandcleavageofDNAbyribosome-inactivatingproteins.BiologicalChemistryHoppe-Seyler,376:637-641. 李向东,唐振华*(1993)马拉硫磷羧酸酯酶在小菜蛾抗药性中的作用.昆虫学研究集刊11:1-10.

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