个人简介

B.A. Cornell University (1996); Ph.D. University of California, Berkeley (2000); NSF Predoctoral Fellow; Berkeley Fellow; Postdoctoral Fellow, U. C. Berkeley (2000) Berkeley; Postdoctoral Fellow, Harvard University (2001-2002); M.I.T. Science Fellow (2002-2003); Packard Fellowship (2005-present); Sloan Fellowship (2006-present); Department of Chemistry Teaching Award (2005-2006); Hellman Family Faculty Fund Award (2006-present); UC Berkeley Distinguished Teaching Award (2011).

研究领域

Theoretical Chemistry

Our research concerns the microscopic behavior of complex biological and material systems. Using the tools and concepts of statistical mechanics, we develop theories and simplified models for chemical phenomena in condensed phases, for biomolecular structure and dynamics, and for the role of fluctuations in nanoscale materials. We also use and devise techniques of modern computer simulation to investigate such systems on molecular length scales. We interact closely with experimental research groups both to inspire and to be inspired by state-of-the-art studies of real physical systems. Among our current interests is the elasticity of disordered networks of semiflexible polymers. Specifically, we are constructing models for the polymeric framework of living cells, which can exhibit dramatic dynamical restructuring. Explaining the microscopic origins of this sensitive response is an essential step in understanding mechanical aspects of cell signaling. A second interest is the dynamics of nanometer-sized solutes in a liquid undergoing phase change. We aim to determine how nonequilibrium fluctuations in such a system can be exploited to guide the spontaneous formation of useful patterned assemblies. The image depicts examples of structures observed in experiments (upper panels of b and d) and predicted by a reduced model of nanocrystal self-assembly.

近期论文

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Xingchen Ye, Matthew R. Jones, Layne B. Frechette, Qian Chen, Alexander S. Powers, Peter Ercius, Gabriel Dunn, Grant M. Rotskoff, Son C. Nguyen, Vivekananda P. Adiga, Alex Zettl, Eran Rabani, Phillip L. Geissler, and A. Paul Alivisatos. "Single-particle mapping of nonequilibrium nanocrystal transformations", Science 2016, 354, 874–877. PDF J. Weichsel and P.L. Geissler. "The More the Tubular: Dynamic Bundling of Actin Filaments for Membrane Tube Formation", PLoS Comp. Bio. 2016. PDF E. M. Schmid, M. H. Bakalar, K. Choudhuri, J. Weichsel, H. S. Ann, P. L. Geissler, M. L. Dustin, and D. A. Fletcher. "Size-dependent protein segregation at membrane interfaces", Nature Physics 2016. PDF K. Klymko, P.L. Geissler, and S. Whitelam. "On the microscopic origin and macroscopic implications of lane formation in mixtures of oppositely-driven particles", ArXiv:1602.01878 2016 T. R. Gingrich, G.M. Rotskoff, G.E. Crooks, and P.L. Geissler. "Near-optimal protocols in complex nonequilibrium transformations", Proc. Natl. Acad. Sci. 2016, 113 10263–10268.PDF A. Widmer-Cooper and P.L. Geissler. "Ligand-Mediated Interactions between Nanoscale Surfaces Depend Sensitively and Nonlinearly on Temperature, Facet Dimensions, and Ligand Coverage", ACS Nano 2016. PDF R. Noriega, D. T. Finley, J. Haberstroh, P. L. Geissler, M. B. Francis, and N. S. Ginsberg. "Extensive Conformational Heterogeneity within Protein Cores", J. Phys. Chem. B 2014, 119, 6963–6973. PDF K.H. Dubay, G.R. Bowman, and P.L. Geissler. "Fluctuations within Folded Proteins: Implications for Thermodynamic and Allosteric Regulation", Acc. Chem. Res. 2015, 48, , 1098–1105. PDF N. Schwierz, C. V. Frost, P.L. Geissler, M. Zacharias. "Dynamics of Seeded Aβ40-Fibril Growth from Atomistic Molecular Dynamics Simulations: Kinetic Trapping and Reduced Water Mobility in the Locking Step", J. Am. Chem. Soc. 2015. PDF M. Gruenwald, S. Tricard, G.M. Whitesides, and P.L. Geissler. "Exploiting non-equilibrium phase separation for self-assembly", Soft Matt. 2015. PDF T. R. Gingrich and P.L. Geissler. "Preserving correlations between trajectories for efficient path sampling", J. Chem. Phys. 2015, 142, 234104. PDF S. Vaikuntanathan, G.M. Rotskoff, A. Hudson, P.L. Geissler. "Necessity of capillary modes in a minimal model of nanoscale hydrophobic solvation", Proc. Natl. Acad. Sci. 2015, 113. PDF G.R. Bowman and P.L. Geissler. "Extensive Conformational Heterogeneity within Protein Cores", J. Phys. Chem. B 2014, 118, 6417–6423. PDF E. Hohlfeld and P.L. Geissler. "Dominance of extreme statistics in a prototype many-body Brownian ratchet", J. Chem. Phys. 2014, 141, 161101. PDF T.R. Gingrich, G.M. Rotskoff, S. Vaikuntanathan, and P.L. Geissler. "Efficieny and large deviations in time-asymmetric stochastic heat engines", New J. Phys. 2014, 16, 102003. PDF T.R. Gingrich, S. Vaikuntanathan, and P.L. Geissler. "Heterogeneity-induced large deviations in activity and (in some cases) entropy production", Phys. Rev. E 2014, 90, 042123. PDF B. Onoa, A.R. Schneider, M.D. Brooks, P. Grob, E. Nogales, P.L. Geissler, K.K. Niyogi, C. Bustamante. "Atomic Force Microscopy of Photosystem II and Its Unit Cell Clustering Quantitatively Delineate the Meoscale Variability in Arabidopsis Thylakoids", PLoS ONE 2014, 9, 1–12. PDF S. Vaikuntanathan, T.R. Gingrich and P.L. Geissler. "Dynamic phase transitions in simple driven kinetic networks", Phys. Rev. E 2014, 89, 062108. PDF A.R. Schneider and P.L. Geissler. "Coarse-grained computer simulation in thylakoid membranes: methods and opportunities", Front. Plant Sci. 2014, PDF M. Grünwald and P.L. Geissler. "Patterns without Patches: Hierarchical Self-Assembly of Complex Structures from Simple Building Blocks", ACS Nano 2014. PDF A.S. Mey, J.P. Garrahan, and P.L. Geissler. "Rare-event trajectory ensemble analysis reveals metastable dynamical phases in lattice proteins", Phys. Rev. E 2014, 89, 032109. PDF S. Vaikuntanathan and P.L. Geissler. "Putting water on a lattice: The importance of long wavelength density fluctuations in theories of hydrophobic and interfacial phenomena", Phys. Rev. Lett. 2014, 112, 020603 1–5. PDF A. Widmer-Cooper and P.L. Geissler. "Orientational Ordering of Passivating Ligands on CdS Nanorods in Solution Generates Strong Rod–Rod Interactions", Nano Lett. 2013. PDF P.L. Geissler. "Water Interfaces, Solvation, and Spectroscopy", Annu. Rev. Phys. Chem. 2013, 64, 317–337. PDF A.R. Schneider and P.L. Geissler. "Coexistence of fluid and crystalline phases of proteins in photosynthetic membranes", Biophys. J. 2013, 103, 1161–1170. PDF