个人简介

Josh Goldberger received his B.S. in chemistry from The Ohio State University in 2001. He received his Ph.D. in chemistry from the University of California at Berkeley with Professor Peidong Yang in 2006, as an NSF graduate fellow. He then did his postdoctoral research with Professor Sam Stupp at Northwestern University as part of the Institute for BioNanotechnology in Medicine, as an NIH-NRSA postdoctoral fellow (2007-2010). He has received many awards, including an MRS Graduate Student Finalist Award in 2003, and an IUPAC Prize for Young Chemists in 2007. He joined the Ohio State Chemistry Department in August of 2010.

研究领域

Inorganic/Materials

Membrane Protein Assembly, Proteases, Biophysics Our lab’s central interest is the determination of how proteins are transported and inserted into membrane to obtain their proper structure. We are employing biochemical and in vivo approaches to understand membrane protein assembly. We have identified a novel protein, YidC that specializes in membrane protein topogenesis. The general relevance of this finding is underscored by the homology of YidC to the mitochondrial Oxa1, which functions in a novel pathway for insertion of inner membrane proteins from the mitochondrial matrix compartment. The goal now is to determine the substrate specificity of YidC, to determine the function of YidC in the integration and folding of multispanning membrane proteins, define the structural features of YidC and the insertion pore of the YidC dimer. Another serious interest here is the study of proteases involved in the cleavage of proteins and peptides that are transiently associated with cellular membranes. These proteases such as signal peptidase and signal peptide peptidases are crucially important for a wide range of essential biological processes. We are very interested in how the cell meets the “chemical challenge” of peptide bond hydrolysis in proteins that are shielded by non-aqueous environments. Recent graduates from the Dalbey lab hold faculty positions at the University of Pittsburg, Simon Fraser University, and Kwandong University. They hold research positions at National Institutes of Health (NIH), MIT, and Duke, and have industrial positions at Novartis, Eli Lilly, and Abbott Pharmaceuticals. Funding from the lab has come primarily from NIH and National Science Foundation (NSF) over the years.

近期论文

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Y.H. Liu, S. H. Porter, J. Goldberger, "Dimensional Reduction of a Layered Metal Chalcogenide into a 1D Near-IR Direct Band Gap Semiconductor" J. Am. Chem. Soc., 134, 5044-7 (2012). A. Ghosh, M. Haverick, K. Stump, X. Yang, M. Tweedle, and J. Goldberger, "Fine-tuning the pH trigger of self-assembly" J. Am. Chem. Soc., 134, 3647-50 (2012) J. Goldberger, E. Berns, R. Bitton, C. Newcomb, S. I. Stupp, "Electrostatic Control of Bioactivity" Angew. Chemie Int. Ed, 50, 6292-5 (2011). M. Sofos*, J. Goldberger*, D. Stone, Q. Ma, D. Herman, W. Tsai, S. I. Stupp "A synergistic assembly of nanoscale lamellar photoconductor hybrids" Nature Materials 8, 68-75 (2009) (*co-authors). J. Goldberger, R. Fan, P. Yang. "Inorganic Nanotubes: A new class of one-dimensional nanostructures" Acc. Chem. Res., 39, 239-43 (2006). J. Goldberger, A. Hochbaum, R. Fan, P. Yang. "Vertical Silicon Nanowire Field Effect Transistors" Nano Lett., 6 973-7 (2006). D.J. Sirbuly, M. Law, J.C. Johnson, J. Goldberger,R.J. Saykally, and P. Yang, "Nanoribbon waveguides for subwavelength photonics Integration" Science, 305, 1269-1273 (2004). J. Goldberger, R.R. He, Y. Zhang, S. Lee, H. Yan, H.J. Choi, P. Yang. "Single-crystal gallium nitride nanotubes" Nature, 422, 599-602 (2003).