个人简介

Prabir K. Dutta received his BS degree in Chemistry from Calcutta University in 1972 and a MS degree from Indian Institute of Technology, Kanpur in 1974. In 1978, he received his Ph.D. degree in Chemistry from Princeton University. After a year of post-doctoral study at Princeton and four years of industrial research at Exxon Research and Engineering Company, he joined The Ohio State University as Assistant Professor. He was promoted to Associate Professor in 1988, and to Professor of Chemistry in 1992. Since 1998, he has been the Robert K Fox Professor of Chemistry. He was named Distinguished University Professor in 2010. He has received several research and teaching awards, including a Society for Applied Spectroscopy Award in 1993, Ohio State Distinguished Scholar Award in 2000 and a Teaching Award in 2000. He is also currently the Deputy Director of the multidisciplinary NSF-funded center, Center for Industrial Sensors and Measurements in the College ofEngineering with responsibility for directing the basic research program in ceramic sensors. Professor Dutta was the Department Chair from 2003 through 2007.

研究领域

Analytical/Materials/Chemical Physics

Membrane Protein Assembly, Proteases, Biophysics Our lab’s central interest is the determination of how proteins are transported and inserted into membrane to obtain their proper structure. We are employing biochemical and in vivo approaches to understand membrane protein assembly. We have identified a novel protein, YidC that specializes in membrane protein topogenesis. The general relevance of this finding is underscored by the homology of YidC to the mitochondrial Oxa1, which functions in a novel pathway for insertion of inner membrane proteins from the mitochondrial matrix compartment. The goal now is to determine the substrate specificity of YidC, to determine the function of YidC in the integration and folding of multispanning membrane proteins, define the structural features of YidC and the insertion pore of the YidC dimer. Another serious interest here is the study of proteases involved in the cleavage of proteins and peptides that are transiently associated with cellular membranes. These proteases such as signal peptidase and signal peptide peptidases are crucially important for a wide range of essential biological processes. We are very interested in how the cell meets the “chemical challenge” of peptide bond hydrolysis in proteins that are shielded by non-aqueous environments. Recent graduates from the Dalbey lab hold faculty positions at the University of Pittsburg, Simon Fraser University, and Kwandong University. They hold research positions at National Institutes of Health (NIH), MIT, and Duke, and have industrial positions at Novartis, Eli Lilly, and Abbott Pharmaceuticals. Funding from the lab has come primarily from NIH and National Science Foundation (NSF) over the years.

近期论文

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Topotactic Transformation of Zeolite Supported Cobalt(II) Hydroxide to Oxide and Comparison of Photocatalytic Oxygen Evolution, Del Pilar-Albaladejo, Joselyn; Dutta, Prabir K., ACS Catalysis (2014),4(1), 9-15 Rapid Crystallization of Faujasitic Zeolites: Mechanism and Application to Zeolite Membrane Growth on Polymer Supports By Severance, Michael; Wang, Bo; Ramasubramanian, Kartik; Zhao, Lin; Ho, W. S. Winston; Dutta, Prabir K. From Langmuir (2014), 30(23), 6929-6937. Interaction of Ammonia with Intrazeolitic Silver ions: Development of an Ammonia Sensor, Yangong Zheng, Max R Mullen, Jing Wang, Prabir K Dutta Sensors & Actuators: B. Chemical (2014), 193, 542-551 Light activated processes with zeolites: recent developments By Dutta, Prabir K.; Chakraborty, Subhrakanti Edited by Suib, Steven L From New and Future Developments in Catalysis: Solar Photocatalysis (2013), 49-62. Influence of crystallite size on cation conductivity in Faujasitic zeolites By Severance, Michael; Zheng, Yangong; Heck, Elizabeth; Dutta, Prabir K. From Journal of Physical Chemistry A (2013), 117(50), 13704-13711. Minimal Intestinal Epithelial Cell Toxicity in Response to Short- and Long-Term Food-Relevant Inorganic Nanoparticle Exposure By McCracken, Christie; Zane, Andrew; Knight, Deborah A.; Dutta, Prabir K.; Waldman, W. James From Chemical Research in Toxicology (2013), 26(10), 1514-1525. Nitric oxide sensors using combination of p- and n-type semiconducting oxides and its application for detecting NO in human breath By Sun, Chenhu; Maduraiveeran, G.; Dutta, Prabir From Sensors and Actuators, B: Chemical (2013), 186, 117-125. Interface reaction and its effect on the performance of a CO2 gas sensor based on Li0.35La0.55TiO3 electrolyte and Li2CO3 sensing electrode By Yoon, Junro; Hunter, Gary; Akbar, Sheikh; Dutta, Prabir K. From Sensors and Actuators, B: Chemical (2013), 182, 95-103. Tuning the Activities and Structures of Enzymes Bound to Graphene Oxide with a Protein Glue, Pattammattel, Ajith; Puglia, Megan; Chakraborty, Subhrakanti; Deshapriya, Inoka K.; Dutta, Prabir K.; Kumar, Challa V. Langmuir (2013), 29(50), 15643-15654. Influence of crystallite size on cation conductivity in Faujasitic zeolites, Severance, Michael; Zheng, Yangong; Heck, Elizabeth; Dutta, Prabir K., Journal of Physical Chemistry A (2013), 117(50), 13704-13711.