个人简介

Professor. Born 1971. B.S. in Chemistry from Miami University, Oxford, OH, 1994. Ph.D. in Organic Chemistry, Harvard University (Prof. Eric N. Jacobsen, advisor), 1999. Postdoctoral Fellow, Miller Institute for Basic Research in Science, Univ. of California, Berkeley (Prof. Jean M. J. Frchet, advisor), 1999-2001. Camille and Henry Dreyfus Foundation New Faculty Award, 2001.

研究领域

Organic, Bioorganic, and Materials Chemistry — Self-assembling networks of inorganic nanocrystals from modified cytoskeletal proteins, functionalized viral capsids for drug delivery and 3-D nanomaterial construction, and new synthetic methods for site-specific protein modification

Organic, Bioorganic, and Materials Chemistry — Self-assembling networks of inorganic nanocrystals from modified cytoskeletal proteins, functionalized viral capsids for drug delivery and 3-D nanomaterial construction, and new synthetic methods for site-specific protein modification Research in the Francis group is focused on the development of new synthetic methods for the construction of nanoscale materials. The central strategy involves the attachment of new functional components to specific locations on structural proteins, and the subsequent self-assembly of these conjugates into new types of materials with useful electronic and biological functions.

近期论文

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Knight AS,* Kulkarni RU,* Zhou EY, Franke JM, Miller EW, Francis MB. A modular platform to develop peptoid-based selective fluorescent metal sensors. Chem. Commun. 2017 ElSohly EM,* MacDonald JI,* Hentzen NB, Aanei IL, El Muslemany KM, Francis MB. Ortho-methoxyphenols as convenient oxidative bioconjugation reagents with application to site-selective heterobifunctional cross-linkers. JACS. 2017 Smith MJ, Francis MB. Improving metabolite production in microbial co-cultures using a spatially constrained hydrogel. Biotechnology and Bioengineering. 2017 Palla KS,* Hurlburt TJ,* Buyanin AM, Somorjai GA, Francis MB. Site-selective oxidative coupling reactions for the attachment of enzymes to glass surfaces through DNA-directed immobilization. JACS. 2017 Furst AL, Hoepker AC, Francis MB. Quantifying hormone disruptors with an engineered bacterial biosensor. ACS Central Science. 2017 Slack CC,* Finbloom JA,* Jeong K, Bruns CJ, Wemmer DE, Pines A, Francis MB. Rotaxane probes for protease detection by 129Xe hyperCEST NMR. Chem. Commun. 2017 Bruns CJ, Liu H, Francis MB. Near-quantitative aqueous synthesis of rotaxanes via bioconjugation to oligopeptides and proteins. JACS. 2016 Finbloom JA, Han K, Aanei IL, Hartman EC, Finley DT, Dedeo MT, Fishman M, Downing KH, Francis MB. Stable disk assemblies of a tobacco mosaic virus mutant as nanoscale scaffolds for applications in drug delivery. Bioconjugate Chem. 2016 Aanei IL, ElSohly AM, Netirojjanakul C, Regan M, Taylor Murphy S, O’Neil JP, Seo Y, Francis MB. Biodistribution of antibody-MS2 viral capsid conjugates in breast cancer models. Mol. Pharm. 2016 Jeong K, Netirojjanakul C, Munch HK, Sun J, Finbloom JA, Wemmer DE, Pines A, Francis MB. Targeted molecular imaging of cancer cells using MS2-based 129Xe NMR. Bioconjug. Chem. 2016 Gomes MD, Phuong D, Jeong K, Slack CC, Vassiliou CC, Finbloom JA, Francis MB, Wemmer DE, Pines A. 129Xe NMR relaxation-based macromolecular sensing. JACS. 2016 Sangsuwan R, Obermeyer A, Tachachartvanich P, Palaniappan KK, Francis MB. Direct detection of nitrotyrosine-containing proteins using an aniline-based oxidative coupling strategy. Chem. Commun. 2016 Lee JP, Kassianidou E, MacDonald JI, Francis MB. N-terminal specific conjugation of extracellular matrix proteins to 2-pyridinecarboxaldehyde functionalized polyacrylamide hydrogels. Biomaterials. 2016 Smith MJ, Francis MB. A designed A. vinelandii-S. elongatus coculture for chemical photoproduction from air, water, phosphate, and trace metals. ACS Synth. Biol. 2016 Rosen CB, Kwant RL, MacDonald JI, Rao M, Francis MB. Capture and recycling of sortase A through site-specific labeling with lithocholic acid. Angew. Chem., Int. Ed. 2016. Parker BF, Knight AS, Vukovic S, Arnold J, Francis MB. A peptoid-based combinatorial and computational approach to developing ligands for uranyl sequestration from seawater. Ind. Eng. Chem. Res. 2016 Finbloom JA, Slack CC, Bruns CJ, Jeong K, Wemmer DE, Pines A, Francis MB. Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by 129Xe hyperCEST NMR. Chem. Commun. 2016. Carrico ZM, Strobel KL, Atreya ME, Clark DS, Francis MB. Simultaneous selection and counter-selection for the directed evolution of proteases in E. coli using a cytoplasmic anchoring strategy. Biotechnology and Bioengineering. 2015. Jeong K, Slack CC, Vassiliou CC, Dao P, Gomes MD, Kennedy DJ, Truxal AE, Sperling LJ, Francis MB, Wemmer DE, Pines A. Investigation of DOTA-Metal Chelation Effects on 129Xe Chemical Shift. Chemphyschem. 2015. ElSohly AM, Netirojjanakul C, Aanei IL, Jager A, Bendall S, Farkas ME, Nolan GP, Francis MB. Synthetically Modified Viral Capsids as Versatile Carriers for Use in Antibody-based Cell Targeting. Bioconjug Chem. 2015 Knight AS, Zhou EY, Francis MB. Development of peptoid-based ligands for the removal of cadmium from biological media. Chemical Science 2015. ElSohly AM and Francis MB. Development of Oxidative Coupling Strategies for Site-Selective Protein Modification. Accounts of Chemical Research 2015. Noriega R, Finley DT, Haberstroh J, Geissler PL, Francis MB, Ginsberg NS. Manipulating Excited-State Dynamics of Individual Light-Harvesting Chromophores through Restricted Motions in a Hydrated Nanoscale Protein Cavity. J Phys Chem B 2015. Glasgow JE, Asensio MA, Jakobson CM, Francis MB, Tullman-Ercek D. The Influence of Electrostatics on Small Molecule Flux through a Protein Nanoreactor. ACS Synth Biol. 2015. Knight AS, Zhou EY, Francis MB, Zuckermann RN. Sequence Programmable Peptoid Polymers for Diverse Materials Applications. Advanced Materials 2015.