唐功利 - 中国科学院上海有机化学研究所 -

个人简介

教育 1990年9月－1994年7月南开大学环境科学系环境化学专业，理学学士。 1994年9月－1999年7月中国科学院上海有机化学研究所，理学博士。工作经历 1999年8月－2000年3月中国科学院上海有机化学研究所助理研究员，课题组副组长 2000年3月－2000年8月中国科学院上海有机化学研究所副研究员，课题组副组长 2000年9月－2001年8月美国加州大学戴维斯分校(University of California-Davis)化学系，博士后访问学者 2001年8月－2003年8月美国威斯康星大学麦迪逊分校 (University of Wisconsin- Madison) 药学院，研究助理(Research associate) 2003年8月－中国科学院上海有机化学研究所研究员，课题组组长

研究领域

1) 天然产物生物合成研究：以微生物来源的结构新奇、活性显著的复杂天然产物为目标分子，从基因和蛋白水平揭示自然界神奇的生物化学过程，理解其中蕴涵的新型酶催化反应和生理拮抗机制。 2) 新颖天然产物的发现和复杂天然产物类药物的高效制备：通过生物合成与生物信息相关联的方法激活沉默基因簇，进而发现全新的天然产物。在揭示生物合成途径的基础上通过化学-生物学相结合的策略来创造"非天然"天然产物；采用微生物代谢工程或合成生物学的方法和策略致力于提高目标化合物的产量，改变发酵产物的组分及产生新化合物；最终通过与化学半合成或生物催化相结合发展高效的制备路线 3) 抗肿瘤天然产物的化学生物学研究：利用优化的噬菌体展示克隆或与生物合成相关联的方法，筛选、发现一些高活性天然产物的生物靶分子，进而研究其生物活性的机理

近期论文

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Wen, W. -H.; Zhang, Y.; Zhang, Y.-Y.; Yu Q, Jiang, C.-C.; Tang, M.-C.; Pu, J.-Y.; Wu, L.; Zhao, Y.-L.; Shi, T.*; Zhou, J.*; Tang, G.-L.* (2021) Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat. Commun. 12, 7085. Zhang, W.-H., Wang, F.; Wang, Y.-L.; You, S.*; Pan, H.-X.*; Tang, G.-L.* (2021) Identification and Characterization of Enzymes Catalyzing Early Steps in Miharamycin and Amipurimycin Biosynthesis. Org. Lett. 23, 8761-8765. Pei, Z.-F.†; Yang, M.-J.†; Zhang, K.; Jian, X.-H.; Tang, G.-L.* (2021) Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs. Cell Chem. Biol. PMID: 34474009. Nie, Q.-Y.; Ji, Z.-Y.; Hu, Y.; Tang, G.-L.* (2021) Characterization of Highly Reductive Modification of Tetracycline D-Ring Reveals Enzymatic Conversion of Enone to Alkane. ACS Catalysis 11, 8399-8406. Hu, Y.; Zhou, Q.; Zhang, Z.; Pan, H.-X.; Ilina, Y.; Metsä-Ketelä, M.; Igarashi, Y.; Tang, G.-L.* (2021) Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis. Chin. J. Chem., 39, 3329-3333. Zhou, Q.†; Peng, S.-Y.†; Zhang, K.; Luo, G.-C.; Han. L.; He, Q.-L.*; Tang, G.-L. * (2021) A Flavin-Dependent Monooxygenase Mediates Divergent Oxidation of Rifamycin. Org. Lett. 23, 2342-2346. Zheng, X.-F.; Liu, X.-Q.; Peng, S.-Y.; Zhou Q.*; Xu. B. *; Yuan, H. *; Tang, G.-L. (2020) Characterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis. Front. Microbiol. 11, 971. Yin, Y.; Shen, Y.; Meng, S.; Zhang, M.; Pan, H.-X.; Tang, G.-L. * (2020) Characterization of a membrane-bound O-acetyltransferase involved in trioxacarcin biosynthesis offers insights into its catalytic mechanism. Chin. J. Chem. 38, 1607-1611. Wang, F.; Zhang, W.-H.; Zhao, J.; Kang, W.-J.; Wang, S.; Yu. B.; Pan, H.-X.*; Tang, G.-L.*(2020) Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. J. Am. Chem. Soc. 142, 5996-6000. Hu, Y.†; Zhang, Z.†; Yin, Y.; Tang, G.-L.*(2020) Directed biosynthesis of iso-aclacinomycins with improved anticancer activity. Org. Lett. 22, 150-154. Ji, Z.-Y.†; Nie, Q.-Y†.; Yin, Y.; Zhang, M.; Pan, H.-X.; Hou, X.-F.*; Tang, G.-L.*(2019) Activation and Characterization of a Cryptic Gene Cluster Reveal Two Series of Aromatic Polyketides Biosynthesized by Divergent Tailoring Pathways. Angew. Chem. Int. Ed. 58, 18046-18054. Jin, W.-B.; Wu, S.; Xu, Y.-F.; Yuan, H.*; Tang, G.-L.* (2019) Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions. Nat. Prod. Rep. 37, 17-28. Zhou, Q.; Luo, G.-C.; Zhang, H.*; Tang, G.-L.* (2019) Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in Micromonospora sp. Strain TP-A0468. Appl. Environ. Microbiol. 85, e02597-18. Shen, Y.; Nie, Q.-Y.; Yin, Y.; Pan, H.-X.; Xu, B.*; Tang, G.-L.*(2019) Production of a trioxacarcin analog by introducing a C-3 dehydratase into deoxysugar biosynthesis. Acta. Biochim. Biophys. Sin. (Shanghai) 51, 539-541. Wang, S.; Zhang, Q.; Zhao, Y.; Sun, J.; Kang, W.; Wang, F.; Pan, H.; Tang, G.; Yu, B.* (2019) The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter. Angew. Chem. Int. Ed. 58, 10558-10562. Pan, H.-X.; Chen, Z.; Zeng, T.; Jin, W.-B.; Geng, Y.; Lin, G. M.; Zhao, J.; Li, W.-T.; Xiong, Z.; Huang, S.-X.; Zhai, X.; Liu, H.-W.*; Tang, G.-L.* (2019) Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. Org. Lett. 21, 1374-1378. Kang, W.-J.†; Pan, H.-X.†; Wang, S.; Yu, B.; Hua, H.*; Tang, G- L.* (2019) Identification of the Amipurimycin Gene Cluster Yields Insight into the Biosynthesis of C9 Sugar Nucleoside Antibiotics. Org. Lett. 21, 3148-3152. Dong, L.; Shen, Y.; Hou, X.-F.; Li, W.-J.*; Tang, G.-L.* (2019) Discovery of Druggability-Improved Analogues by Investigation of the LL-D49194alpha1 Biosynthetic Pathway. Org. Lett. 21, 2322-2325. Zhou, Q.; Luo, G.-C.; Zhang, H.-Z.*; Tang, G.-L.* (2019) 34a-Hydroxylation in Rifamycin Biosynthesis Catalyzed by Cytochrome P450 Encoded by rif-orf13. Chin. J. Org. Chem. 39, 1169-1174. Wang, X.; Wu, S.; Jin, W.; Xu, B.*; Tang, G.*; Yuan, H.* (2018) Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin. Acta. Biochimica. Et Biophysica. Sinica. , 50, 516-518. Pei, Z.-F.†; Yang, M.-J.†; Li ,L.†.; Jian, X.-H.; Yin, Y.; Li, D.; Pan, H.-X.; Lu, Y.; Jiang, W*.; Tang, G.-L.* (2018) Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system. Org. Biomol. Chem. 16, 9373-9376. Wang, S.; Sun, J.; Zhang, Q.; Cao, X.; Zhao, Y.; Tang, G.; Yu, B.* (2018) Amipurimycin: Total Synthesis of the Proposed Structures and Diastereoisomers. Angew. Chem. Int. Ed. 57, 2884-2888. Chen, X.-Y. †; Yin, Y. †; Xi, J.; Yuan, Y.; Li, Y.; Li, Q.; Wang, R.-X.; Yao, Z.*; Tang, G.-L.* (2018) 11‐Aza‐artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6). Chin. J. Chem. 36, 1197-1201. Hou, X.-F.†; Song, Y.-J.†; Zhang, M.; Lan, W.; Meng, S.; Wang, C.; Pan, H.-X.; Cao, C.*; Tang, G.-L.* (2018) Enzymology of Anthraquinone-γ-Pyrone Ring Formation in Complex Aromatic Polyketide Biosynthesis. Angew. Chem. Int. Ed. 57,13475-13479. Zhang, Y.†; Wen, W.-H.†; Pu, J.-Y.; Tang, M.-C.; Zhang, L.; Peng, C.; Xu, Y.; Tang, G.-L.* (2018) Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. Proc. Natl. Acad. Sci. USA. 115,11232-11237. 金文兵; 袁华; 唐功利* (2018) 天然产物中环丙烷官能团的构筑策略. 有机化学 38, 2324-2334. Meng, S.; Tang, G.-L.*; Pan, H.-X.* (2018) Enzymatic formation of oxygen‐containing heterocycles in natural product biosynthesis. ChemBioChem 19, 2002-2022. Jin, W.-B.†; Wu, S.†; Jian, X.-H.; Yuan, H.*; Tang, G.-L.* (2018) A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. Nat. Commun. 9:2771. Qi, F.†; Lei, C.†; Li, F.; Zhang, X.; Wang, J.; Zhang, W.; Fan, Z.; Li, W.; Tang, G.-L.; Xiao, Y.*; Zhao, G.; Li, S.* (2018) Deciphering the late steps of rifamycin biosynthesis. Nat. Commun. 9:2342. Wang, X.; Wu, S.; Jin, W.-B.; Xu, B.*; Tang, G.-L.*, Yuan, H.* (2018) Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin. Acta Biochim. Biophys. Sin. 50, 516-518. Meng, S.; Han, W.; Zhao, J.; Jian, X.; Pan, H.-X.*; Tang, G.-L.* (2018) A Six‐Oxidase Cascade for Tandem C−H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. Angew. Chem. Int. Ed. 57, 719-723.