曹日晖 - 中山大学 - 化学工程与技术学院（珠海）

研究领域

1. 新型抗肿瘤药物的设计、合成、筛选及分子机理研究； 2. 新型酪氨酸酶抑制剂的设计、合成、筛选及机制研究；

近期论文

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Chunming Ma, Rihui Cao*, Buxi Shi, Xiantai Zhou, Qin Ma, Jie Sun, Liang Guo, Wei Yi, Zhiyong Chen, Huacan Song*. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines. European Journal Medicinal Chemistry. 2010, 45, 5513-5519. (通讯作者,SCI收录，IF=3.269). Zhiyong Chen, Rihui Cao*, Liang Yu, Buxi Shi, Jie Sun, Liang Guo, Qin Ma, Wei Yi, Xiao Song, Huacan Song*. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives. European Journal Medicinal Chemistry. 2010, 45, 4740-4745. (通讯作者,SCI收录，IF=3.269). Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Huacan Song. Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58 (9), 1216-1220. (SCI收录，IF=1.698 ). Zhiyong Chen, Rihui Cao*, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren, Wenlie Peng. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3876-3879. (通讯作者,SCI收录，IF=2.650). Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Wenlie Peng, Huacan Song*. Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3254-3258. (SCI收录，IF=2.650). Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Huan Wen, Qin Yan, Lin Ma and Huacan Song*. Rational Design and Synthesis of 4-O-Substituted Phenylmethylenethiosemicarbazones as Novel Tyrosinase Inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58, 752-754. (SCI收录，IF=1.698 ). Zhiyong Chen, Rihui Cao, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren*. Synthesis and Biological Evaluation of Novel β-Carbolines as Potent Cytotoxic and DNA Intercalating Agents. Chemical & Pharmaceutical Bulletin. 2010, 58 (7), 901-907. (SCI收录，IF=1.698 ). Rihui Cao*, Xiangdong Guan, Buxi Shi, Zhiyong Chen, Zhenhua Ren, Wenlie Peng, Huacan Song. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents. European Journal Medicinal Chemistry. 2010, 45 (6) 2503-2515. (通讯作者,SCI收录，IF=3.269). Chunming Ma, Rihui Cao*, Buxi Shi, Shaoxue Li, Zhiyong Chen, Wei Yi, Wenlie Peng, Zhenhua Ren, Huacan Song*. Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates. European Journal Medicinal Chemistry. 2010, 45：1515-1523. (通讯作者,SCI收录，IF=3.269). Wei Yi, Rihui Cao*, Wenlie Peng, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. European Journal Medicinal Chemistry. 2010, 45，639-646. (通讯作者,SCI收录，IF=3.269). Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Lin Ma, Huacan Song*. Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors. Chemical & Pharmaceutical Bulletin. 2009, 57, 1273-1277. (SCI收录，IF=1.698 ). Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Discovery of 4-functionalized phenyl-O-β-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 6157-6160. (通讯作者,SCI收录，IF=2.650). Qin Yan, Rihui Cao*, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma, Huacan Song*. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-D-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 4055-4058. (通讯作者,SCI收录，IF=2.650). Qin Yan, Rihui Cao*, Wei Yi, Zhiyong Chen, Huan Wen, Lin Ma, Huacan Song*. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. European Journal Medicinal Chemistry. 2009, 44, 4235-4243. (通讯作者,SCI收录，IF=3.269). Yi Wei, Xiaoqin Wu, Rihui Cao, Huacan Song, Lin Ma*. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants. Food Chemistry. 2009, 117, 381-386. (SCI收录，IF=3.146 ). Jinbing Liu, Rihui Cao*, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song*. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds. European Journal Medicinal Chemistry. 2009, 44: 1773-1778. (通讯作者,SCI收录，IF=3.269). Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Yiqian Wan, Lin Ma, Huacan Song*. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18: 6490-6493. (通讯作者,SCI收录，IF=2.650). Jinbing Liu, Rihui Cao, Qifeng Wu, Chunming Ma, Zihou Wang, Wenlie Peng, Huacan Song*. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives. European Journal Medicinal Chemistry. 2009, 44: 1737-1744. (SCI收录，IF=3.269). Qifeng Wu, Rihui Cao*, Manxiu Feng, Xiangdong Guan, Chunming Ma, Jinbing Liu, Huacan Song, Wenlie Peng*. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives. European Journal Medicinal Chemistry. 2009, 44, 533-540. (通讯作者，SCI收录，IF=3.269). Rihui Cao*, Wei Yi, Qifeng Wu, Xiangdong Guan, Manxiu, Feng, Chunming Ma, Zhiyong Chen, Huacan Song, Wenlie Peng*. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry Letters. 2008, 18 : 6558-6561. (通讯作者，SCI收录，IF=2.650).