Martí, Angel - Rice University - Department of Chemistry

个人简介

B.S. Chemistry (1999) University of Puerto Rico Ph.D. Inorganic Chemistry (2004) University of Puerto Rico Postdoctoral Research Associate (2004-2008) Columbia University, NY

研究领域

Our research group is interested in the design and synthesis of multifunctional molecular constructs for the treatment and diagnosis of amyloid forming diseases such as Alzheimer's and Parkinson's Disease, in addition to the development of sensors and the in vivo and in vitro detection of DNA and mRNA. 5.2 million people suffer Alzheimer's in the United States. By 2050, this number will increase to 14 million unless a cure is found. Finding novel treatments for Alzheimer's disease represents a challenge that will involve different scientific disciplines. Our approach involves the use of molecular scissors to degrade and solubilize amyloid deposits. These amyloid scissors consist of a recognition element capable of selectively binding to amyloid plaques, bound to an artificial protease capable of cleave proteins, similar to those in amyloid plaques. We also aim to attach paramagnetic species such as gadolinium compounds to amyloid recognition elements for use as diagnosis tools in conjuction with MRI techniques. Other projects involve the design of probes for the detection and monitoring of DNA and mRNA in different media. This will include the use of hybridization probes with an oligonucleotide sequence complementary to the target sequence of interest, and a fluorescent reporter group capable of changing its photophysical properties upon binding to the target sequence. Our group is also interested in investigating the changes in structure that the protein alpha-synuclein undergoes when it binds to membranes and small molecules such as melanin. Alpha-synuclein has been associated with the pathology of Parkinson's disease. We will use spectroscopic methods such as FTIR and circular dichroism to determine the changes in structure of this protein when interacting with different molecular and supramolecular agents.

近期论文

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Jiang, C.; Saha, A.; Young, C. C.; Hashim, D. P.; Ramirez, C.; Ajayan, P. M.; Pasquali, M.; Martí, A. A. Macroscopic Nanotube Fibers Spun from Single-Walled Carbon Nanotube Polyelectrolites ACS Nano 2014, DOI: 10.1021/nn502552q. (Link) Saha, A.; Jiang, C.; Martí, A. A. Carbon Nanotube Networks on Different Platforms Carbon 2014, 79, 1-18. (Link) Mondal, P.; Ghosal, K.; Bhattacharyya, S. K.; Das, M.; Bera, A.; Ganguly, D.; Kumar, P.; Dwivedi, J.; Gupta, R. K.; Martí, A. A.; Gupta, B. K.; Maiti, S. Formation of a Gold–Carbon Dot Nanocomposite with Superior Catalytic Ability for the Reduction of Aromatic Nitro Groups in Water, RSC Adv. 2014, 4, 25863-25866. (Link) Hwang, C. -C.; Ruan, G.; Wang, L.; Zheng, H.; Samuel E. L. G.; Xiang, C.; Wei, L.; Kasper, W.; Huang, K.; Peng, Z.; Schaefer, Z.; Kan, A. T.; Martí, A. A.; Wong, M. S.; Tomson, M. B.; Tour, J. M. Carbon-based Nanoreporters Designed for Subsurface Hydrogen Sulfide Detection, ACS Appl. Mater. Interfaces 2014, 6, 7652-7658. (Link) Ye, R.; Xiang, C.; Lin, J.; Peng, Z.; Huang, K.; Yan, Z.; Cook, N. P.; Samuel, E. L. G.; Hwang, C. -C.; Ruan, G.; Ceriotti, G.; Raji, A. -R. O.; Martí, A. A.; Tour, J. M. Coal as an Abundant Source of Graphene Quantum Dots, Nat. Commun. 2013, 4, 2943. (Link) Shi, Y.; Rhodes, N. R.; Abdolvahabi, A.; Kohn, T.; Cook, N. P.; Abdovahabi, A.; Mowery, R. A.; Martí, A. A.; Shaw, B. F. Deamidation of Asparagine to Aspartate Destabilizes Cu, Zn Superoxide Dismutase, Accelerates Fibrillization and Mirrors ALS-Linked Mutations J. Am. Chem. Soc. 2013, 135, 15897-15908. (Link) Saha, S.; Panos, Z.; Hanna, T.; Huang, K.; Hernández-Rivera, M.; Martí, A. A. 3- Dimensional Solvent Vapor Map Generated by Supramolecular Metal Complex Entrapment Angew. Chem. Int. Ed. 2013, 52, 12615-12618. (Link) Cook, N. P.; Ozbil, M.; Katsampes, C.; Prabhakar, R.; Martí, A. A. Unraveling the Photoluminescence Response of Light-Switching Ruthenium(II) Complexes Bound to Amyloid-β J. Am. Chem. Soc. 2013, 135, 10810-10816. (Link) Jiang, C.; Saha, A.; Changsheng, X.; Young, C.; Tour, J. M.; Pasquali, M.; Martí, A. A. Increased Solubility, Liquid-Crystalline Phase, and Selective Functionalization of Single-Walled Carbon Nanotube Polyelectrolyte Dispersions ACS Nano 2013, 7, 4503-4510. (Link) Cook, N. P.; Archer, C. M.; Fewver, J. N.; Schall, H. E.; Rodriguez-Rivera, J.; Dineley, K. T.; Martí, A. A.; Murray, V. J. I. Ruthenium Red Colorimetric and Birefringent Staining of Amyloid β Aggregates ACS Chem. Neurosci. 2013, 4, 379-384. (Link) Diaz, A.; Mosby, B.; Bakhmutov, V.; Martí, A. A.; Batteas, J.; Clearfield, A. Self Assembled Monolayers Based Upon a Zirconium Phosphate Platform Chem. Mater. 2013, 25, 723-728. (Link) Cook, N. P.; Kilpatrick, K.; Segatori, L.; Martí, A. A. Detection of α-Synuclein Amyloidogenic Aggregates In Vitro and in Cells using Light-Switching Dipyridophenazine Ruthenium(II) Complexes J. Am. Chem. Soc. 2012, 134, 20776-20782. (Link) Huang, K.; Bulik, I.; Martí, A. A. Time-Resolved Photoluminescence Spectroscopy for the Detection of Cysteine and Other Thiol Containing Amino Acids in Complex Strongly Autofluorescent Media Chem. Commun. 2012, 48, 11760-11762. (Link) Cook, N. P.; Martí, A. A. Facile Methodology for Monitoring Amyloid-β Fibrillization ACS Chem. Neurosci. 2012, 3, 896-899. (Link) Huang, K.; Martí, A. A. Optimizing the Sensitivity of Photoluminescent Probes using Time-Resolved Spectroscopy: A Molecular Beacon Case Study Anal. Chem. 2012, 84, 8075-8082. (Link) Gupta, B. K.; Narayanan, T. N.; Vithayathil, S. A.; Lee, Y.; Koshy, S.; Reddy, A. L. M.; Saha, A.; Shanker, V.; Singh, V. N.; Kaipparettu, B. A.; Martí, A. A.; Ajayan, P. M. Highly Luminescent-Paramagnetic Nanophosphor Probes for in Vitro High-Contrast Imaging of Human Breast Cancer Cells Small, 2012, 8, 3028-3034. (Link) Saha, A.; Ghosh, S.; Weisman, R. B.; Martí, A. A. Films of Bare Single-Walled Carbon Nanotubes from Superacids with Tailored Electronic and Photoluminescence Properties. ACS Nano 2012, 6, 5727-5734. (Link) Reddy, A. L. M.; Gupta, B. K.; Narayanan, T. N.; Martí, A. A.; Ajayan, P. M.; Walker, G. C. Probing on Time-Resolved and Photoluminescence Spectroscopy of Ni Encapsulated Ferromagnetic Boron Nitride Nanotubes J. Phys. Chem. C 2012, 116, 12803-12809. (Link) Peng, J.; Gao, W.; Gupta, B. K.; Liu, Z.; Romero-Aburto, R.; Ge, L.; Song, L.; Alemany, L. B.; Zahn, X.; Gao, G.; Vithayathil, S. A.; Kaipparettu, B. A.; Martí, A. A.; Hayashi, T.; Zhu, J. -J.; Ajayan, P. M. Graphene Quantum Dots Derived from Carbon Fibers Nano Lett. 2012, 12, 844-849. (Link) Huang, K.; Martí, A. A. Recent Trends in Molecular Beacons Design and Applications. Anal. Bioanal. Chem. 2012, 402, 3091-3102. (Link)