Landes, Christy - Rice University - Department of Chemistry

个人简介

B.S. Chemistry (1998) George Mason University Ph.D. Chemistry and Biochemistry (2003) Georgia Institute of Technology

研究领域

As experimental physical chemists, the overall goal of our research is to understand the frequently complex structure-function relationships in biological processes and to use this information to inspire innovation for materials design. Practical goals in materials engineering include minimal cost, maximum efficiency, and optimized longevity. As our experimental and theoretical methods to study nature’s molecular-scale design principles have improved, we have begun to understand that one reason nature can be so successful is that her engineering strategy often differs from ours. Whereas humans usually design materials with a single, well-defined function, nature often acts through redundant or degenerate channels that are individually not as efficient, but collectively, and in the face of damage or wear, outperform their synthetic cousins. Obtaining clues from the biological structure-function interplay presents challenges for theory, experiment, and data analysis. When we study one molecule at a time, we eliminate ensemble averaging, thereby accessing any underlying conformational complexity. However, we must develop new methods to increase information content in the resulting low signal-to-noise single-molecule data. Thus, our research efforts have focused on three specific objectives necessary to achieve the overall goal discussed above: 1) Develop experimental data acquisition and analysis methods to optimize information retrieval in single-molecule and single- particle spectroscopies. 2) Characterize biological examples of heterogeneous structure-function relationships. 3) Identify, understand, and optimize heterogeneous structure-function relationships in synthetic systems.

近期论文

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Landes, C.F. Next Generation Fluorescence Microscopy Methods to Elucidate Bacterial Structure/Function. Molecular Microbiology. 2015, in press. Poongavanam, M. -V.; Kisley, L.; Kourentzi, K.; Willson, R.C.; Landes, C. F. Ensemble and Single-Molecule Biophysical Characterization of D17.4 DNA Aptamer-IgE Interactions. Submitted. Kisley, L.; Landes, C. F.; Molecular Approaches to Chromatography Using Single Molecule Spectroscopy. Anal. Chem. 2015, 87, 83-98. Taylor, J. N.; Li, C. B.; Cooper, D. R.; Landes, C. F.; Komatsuzaki, T. Error-based Extraction of Effective Free Energy Landscapes from Experimental Single-Molecule Time-Series. Scientific Reports. 2015 Cooper, D.; Dolino, D.; Shuang, B.; Henriette Jaurich, H.; Ramaswamy, S.; Chen, J.; Jayaraman, V.; Landes, C. F. Conformational Studies of the NMDA Receptor via Single Molecule FRET Technique Under Revision Dolino, D.; Cooper, D.; Ramaswamy, S.; Henriette Jaurich, H.; Landes, C. F. ; Jayaraman, V. Structural Dynamics of the Glycine-Binding Domain of the N-Methyl-D-Aspartate Receptor. J. Biol. Chem., 2015, 290, 797-804. Landes, C.F.; Link. S.; Wine, P.H.; Zhang, Z.J. 2013 Southeastern Regional ACS Meeting. Nanochemistry and Spectroscopy: Symposium Honoring Mostafa El-Sayed. J. Phys. Chem. C. 2014. 14009-14009. Chen, J; Poddar, N. K.; Tauzin, L. J.; Cooper, D.; Kolomeisky, A. B.;Landes, C. F.Single-Molecule FRET Studies of HIV TAR- DNA Hairpin Unfolding Dynamics.J. Phys. Chem. B, 2014, 118(42),12130–12139 Hu, Z.; Adachi, T.; Haws, R.T.; Shuang, B.; Ono, R.J.; Bielawski, C.W.; Landes, C.F.; Rossky, P.J.; Vanden Bout, D.A. Excitonic Energy Migration in Conjugated Polymers: The Critical Role of Interchain Morphology JACS, 2014, 136 (45), 16023–16031 Shuang, B.; Cooper, D.; Taylor, J. N.; Kisley, L.; Chen, J.; Wang, W.; Li, C. B.; Komatsuzaki, T.; Landes, C. F. Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis J. Phys Chem Lett., 2014, 5 (18), 3157-3161 Byers, C. P.; Hoener, B. S.; Chang, W.S.; Yorulmaz, M.; Link, S.; Landes, C. F. Single-Particle Spectroscopy Reveals Heterogeneity in Electrochemical Tuning of the Localized Surface Plasmon. J. Phys. Chem. B, 2014, 118 (49), pp 14047–14055 Tauzin, L. J.; Shuang, B.; Kisley, L. M.; Mansur, A. P.; Chen, J.; Leon, A.; Advincula, R. C.; Landes, C. F. Charge-Dependent Transport Switching of Single Molecular Ions in a Weak Polyelectrolyte Multilayer. Langmuir, 2014, 30, 8391-8399 Kisley, L.; Chen, J.; Mansur, A. P.; Dominguez-Medina, S.; Kulla, E.; Kang, M.; Shuang, B.; Kourentzi, K.; Poongavanam, M. -V.; Dhamane, S.; Willson, R.C.; Landes, C. F. High ionic strength narrows the population of sites participating in protein ion-exchange adsorption: A single-molecule study. J. Chromatogr. A., 2014, 1343, 135-142. Kisley, L.; Chen, J.; Mansur, A. P.; Shuang, B.; Kourentzi, K.; Poongavanam, M. -V.; Chen, W. -H.; Dhamane, S.; Willson, R.C.; Landes, C. F. Unified superresolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations. Proc. Natl. Acad. Sci., 2014, 111, 2075-2080. Shuang, B.; Chen, J.; Kisley, L.; Landes, C. F. Troika of Single Particle Tracking Programing: SNR Enhancement, Particle Identification, and Mapping Phys. Chem. Chem. Phys., 2014, 16, 624-634 Chen, J.; Bremauntz, A.; Kisley, L.; Shuang, B.; Landes, C. F. Super-Resolution mbPAINT for Optical Localization of Single- Stranded DNA. ACS Appl. Mater. Interfaces, 2013, 5, 9338-9343. Dominguez-Medina, S., Blankenburg, J., Olson, J., Landes, C. F., Link, S. Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions. ACS Sustainable Chemistry & Engineering, 2013, 1(7), 833-842 Kawai, S.; Cooper, D.; Landes, C.F.; Mootz, H.D.; Yang, H.; Komatsuzaki, T. Numerical Construction of Estimators for single-molecule fluorescence measurements. J. Phys. Chem. B, 2013, 117(27), 8061–8074 Kisley, L.; Chang, W. -S.; Cooper, D.; Mansur, A. P.; Landes, C. F. Extending single molecule fluorescence observation time by amplitude modulated excitation. Methods Appl. Fluoresc., 2013, 1, 037001. Cooper, D.; Uhm, H.; Tauzin, L. J.; Poddar, N.; Landes, C.F. Photobleaching Lifetimes of Cyanine Dyes Used for Single Molecule Förster Resonance Energy Transfer in the Presence of Various Photoprotection Systems.ChemBioChem, 2013, 14,1075 Shuang, B.; Byers, C.P.; Kisley, L.; Wang, L. Y.; Zhao, J.; Morimura, H.; Link, S.; Landes, C. F. Improved analysis for determining diffusion coefficients from short, single-molecule trajectories with photoblinking. Langmuir, 2013,29(1), 228-234. Daniels C. R.; Tauzin L. J.; Foster E.; Advincula R. C.; Landes, C. F. On the pH-Responsive, Charge-Selective, Polymer-Brush-Mediated Transport Probed by Traditional and Scanning Fluorescence Correlation Spectroscopy. J. Phys. Chem. B,2013, 117(16), 4284–4290 Ramaswamy, S.; Cooper, D; Poddar, N.; Rambhadran, A.; Taylor, J. N.; Uhm, H.; Landes, C.F.; Jayaraman, V. Partial agonism of AMPA receptors studied by single molecule FRET investigations. J. Biol. Chem., 2012, 287, 43557-43564. Dominguez-Medina, S.; McDonough, S.; Swanglap, P.; Landes, C. F.; Link, S. In Situ Measurement of Bovine Serum Albumin Interaction with Gold Nanospheres. Langmuir, 2012, 28 (24), 9131-9139 Reznik, C.; Landes, C. F. Transport in Supported Polyelectrolyte Brushes. Acc. Chem. Res., 2012, 45, 1927-1935.