Hartgerink, Jeffrey D. - Rice University

个人简介

A. B. Chemistry and Biology (1993) Washington University Ph.D. Molecular and Cellular Structure and Chemistry (1999) The Scripps Research Institute

研究领域

Supramolecular chemistry is an emerging sub-discipline of chemistry that primarily concerns itself with non-covalent intermolecular interactions. These relatively weak forces are used in large number to create nanometer sized objects in a massively parallel fashion. The inspiration for this area of research comes primarily from advances in our understanding of biological systems and the miraculous structures found therein. Great strides have been made to mimic both the structures found in biological systems and the approaches that biology uses to create these structures. Although many of these advances are truly remarkable, and many may find practical application in the future, a situation has arisen where we are able to produce materials which have no easy method of manipulation or organization into higher order structures. It is analogous to being able to produce a wheel and an axle and having no way to connect them to one another, let alone to a cart. Alternatively one could compare this stage of supramolecular chemistry to traditional organic synthesis of a century ago when the number of chemical transformation and protecting groups were severely limited. In order to bring supramolecular chemistry to a new level of sophistication methods by which two or more supramolecular objects can be coupled or organized must be developed. My research is directed at solving this problem by employing a second step of self-assembly, covalent capture and / or mineralization to create complex and functional assemblies. Three projects are starting in my lab which address this. The first uses the self-assembly of ?coiled-coils? (a pair of alpha-helical peptides wound around one another) as a framework for the secondary self-assembly of a conductive organic matrix to form wires with nanometer dimensions. These wires, unlike most other approaches to nanoscale electronics, may be able to organize themselves in neural networks that can readily interface with traditional electronics. The second project is geared toward the synthesis of an artificial extracellular matrix (ECM) for use as a drug and cell delivery vehicle and tissue regeneration therapies. This biomimetic material will be prepared through two steps of self-assembly followed by covalent capture. The third project targets the synthesis of novel catalysts and magnetic materials. The preparation of these materials uses the mechanisms involved in biomineralization that allow biology to create an amazing diversity of inorganic and composite materials such as shells, teeth and bone.

近期论文

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N. C. Wickremasinghe, V. A. Kumar, J. D. Hartgerink "Two Step Self-assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release" Biomacromolecules, in press. J. S. Colombo, A. N. Moore, J. D. Hartgerink, R. N. D'Souza "Scaffolds to Control Inflammation and Facilitate Dental Pulp Regeneration" J. Endodontics 40, 4 S6-S12 (2014). A. A. Jalan, K. A. Jochim, J. D. Hartgerink "Rational Design of a Non-canonical "Sticky-ended" ABC-Collagen Triple Helix" J. Am. Chem. Soc. 136, 7535-7538 (2014). M. K. Kang, J. Colombo, R.N. D'Souza, J. D. Hartgerink "Sequence effects of self-assembling MultiDomain Peptide Hydrogels on encapsulated SHED cells" Biomacromolecules, 15, 2004-2011 (2014). V. A. Kumar, N. L. Taylor, A. A. Jalan, L. K. Hwang, B. K. Wang, J. D. Hartgerink "A Novel Synthetic Collagen Mimic for Hemostasis" Biomacromolecules 15, 1484-1490 (2014). A. A. Jalan, J. D. Hartgerink "Unraveling pairwise interactions in collagen and the design of heterotrimeric helices" Curr. Opin. Chem. Biol. 17, 6, 960-967 (2013). A. A. Jalan, B. Demeler, J. D. Hartgerink "Hydroxyproline-Free Single Composition ABC Collagen Heterotrimer" J. Am. Chem. Soc. 135, 6014-6017 (2013). E. L. Bakota, O. Sensoy, B. Ozgur, M. Sayar, and J. D. Hartgerink "Self-Assembling Multidomain Peptide Fibers with Aromatic Cores" Biomacromolecules 14, 1370-1378 (2013). A. A. Jalan and J. D. Hartgerink "Simultaneous Control of Composition and Register of an AAB-type Collagen Heterotrimer" Biomacromolecules 14, 179-185 (2013). J. A. Fallas and J. D. Hartgerink "Computational Design of Self-Assembling Register-Specific Collagen Heterotrimers" Nat. Comm., 3, 1087 (2012). Fang Wei, J. Fallas and J. D. Hartgerink "Sequence Position and Side Chain Length Dependence of Charge Pair Interactions in Collagen Triple Helices" Macromol. Rapid. Comm. 33, (17), 1445-1452 (2012). J. A. Fallas, J. Dong, Y. J. Tao and J. D. Hartgerink "Structural insights into charge pair interactions in triple helical collagen-like proteins" J. Biol. Chem. 287 8039-47 (2012). J. A. Fallas, M. A. Lee, Abhishek A. Jalan, and J. D. Hartgerink "Rational Design of Single-Composition ABC Collagen Heterotrimers" J. Am. Chem. Soc.,134, 1430-1433 (2012).