宫永宽 - 西北大学 - 化学与材料科学学院

研究领域

1.功能化仿细胞膜结构聚合物的设计与合成；2.仿细胞膜结构及贻贝万能粘附表面改性；3.癌症精确诊断及治疗用新型纳米载体材料；4.仿细胞膜结构高性能人工器官研究。主要从事生物医用高分子材料的合成及应用研究。仿照细胞膜的结构及功能，合成了含磷酰胆碱基团的高分子单体及多种聚合物，研究了含磷酰胆碱两亲共聚物在材料表面的调控组装及其聚集结构；建立了用仿细胞膜结构修饰生物材料表面的一系列方法。

近期论文

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Yuan Dang, Miao Quan, Cheng-Mei Xing, Yan-Bing Wang and Yong-Kuan Gong. Biocompatible and antifouling coating of cell membrane phosphorylcholine and mussel catechol modified multi-arm PEGs. Journal of Materials Chemistry B, 2015, 3: 2350–2361. Jing Zhao, Yu-Dong Chai, Jing Zhang, Peng-Fei Huang, Kenichi Nakashima, Yong-Kuan Gong. Long circulating micelles of an amphiphilic random copolymer bearing cell outer membrane phosphorylcholine zwitterions. Acta Biomaterialia, 2015, 16: 94–102. Yan-Bing Wang, Ming Gong, Shan Yang, K. Nakashima, Yong-Kuan Gong, Hemocompatibility and film stability improvement of crosslinkable MPC copolymer coated polypropylene hollow fiber membrane. Journal of Membrane Science, 2014, 452: 29-36. Ming Gong, Yuan Dang, Yan-Bing Wang, Shan Yang, Françoise M. Winnik and Yong-Kuan Gong. Cell membrane mimetic films immobilized by synergistic grafting and crosslinking. Soft Matter, 2013, 9: 4501-4508. Yong-kuan Gong, Liping Liu, Phillip B. Messersmith. Doubly Biomimetic Catecholic Phosphorylcholine Copolymer:A Platform Strategy for Fabricating Antifoul-ing Surfaces, Macromolecular Bioscience, 2012, 12: 979-985. Dominic E. Fullenkamp, JoséG Rivera, Yong-kuan Gong, K. H. AaronLau, Lihong He, Rahul Varshney, Phillip B. Messersmith, Mussel-inspired silver-releasing antibacterial hydrogels. Biomaterials, 2012, 33(15): 3783-3791. Yong-kuan Gong, Françoise M. Winnik. Strategies in biomimetic surface engineering of nanoparticles for biomedical applications. Nanoscale, 2012, 4: 360-368. Ming Gong, Yan-Bing Wang, Ming Li, Bi-Huang Hu, Yong-Kuan Gong. Fabrication and hemocompatibility of cell outer membrane mimetic surfaces on chitosan by layer by layer assembly with polyanion bearing phosphorylcholine groups. Colloids and Surfaces B: Biointerfaces, 2011, 85: 48-55. Suqing Shi, Pu Xiao, Kemin Wang, Yongkuan Gong and Jun Nie. Influence of chemical structures of benzodioxole-based coinitiators on properties of unfilled dental resins. Acta Biomaterialia, 2010, 6(8): 3067-3071. Peng-bo Huangfu, Ming Gong, Cunfu Zhang, Shan Yang, Jiang Zhao, Yong-kuan Gong. Cell outer membrane mimetic modification of across-linked chitosan surface to improve its hemocompatibility. Colloids and Surfaces B:Biointerfaces, 2009, 71: 268-274. Shan Yang, Shi-Ping Zhang, F. M. Winnik, F. Mwale, Yong-Kuan Gong. Group reorientation and migration of amphiphilic polymer bearing phosphorylcholine functionalities on surface of cellular membrane mimicking coating. J. Biomed. Mater. Res. A, 2008, 84A(3): 837-841. Ming Gong, Shan Yang, Jia-ni Ma, Shi-ping Zhang, Françoise M. Winnik, Yong-kuan Gong. Tunable cell membrane mimetic surfaces prepared with anovel phospholipid polymer. Appl. Surf. Sci., 2008, 255: 555-558. Yong-Kuan Gong, Li Luo, Alain Petit, David J. Zukor, Olga L. Huk, John Antoniou, Françoise M. Winnik, Fackson Mwale. Adhesion of human U937 macrophages to phosphorylcholine-coated surfaces. J. Biomed. Mater. Res. Part A, 2005, 72A(1): 1-9. Feng Shen, Anna Aihua Li, Yong-Kuan Gong, Sat Somers, Murray A. Potter, Francoise M. Winnik. Patricia L.Chang,Encapsulation of Recombinant Cells with aNovel Magnetized Alginate for Magnetic Resonance Imaging. Human Gene Therapy, 2005, 16(8): 971-984. Yong-Kuan Gong, Fackson Mwale, Michael R. Wertheimer, Francoise M. Winnik. Promotion of U937 cell adhesion on polypropylene surfaces bearing phosphorylcholine functionalities. J. Biomater. Sci., Polymer Edition, 2004, 15(11): 1423-1434. Yong-Kuan Gong and Kenichi Nakashima. Photoinduced Electron Transfer from Pyrenes to Alkyl Viologens on the Surface of Polystyrene Latex Particles:Effects of Polarities of the Donors and Charge Densities of the Particles. J. Phys. Chem. B, 2002, 106(4): 803-808. Yong-Kuan Gong, Kenichi Nakashima and Renliang Xu. A Novel Method to Determine Effective Charge of PS Latex Particles in Aqueous Dispersion. Langmuir, 2001, 17: 2889-2892. Yong-Kuan Gong and Kenichi Nakashima. Penetration of Pyrene and its derivatives into PS Latex Particles as Studied by Fluorescence Techniques. Chem. Commun., 2001, 1772-1773. Yong-Kuan Gong, Kenichi Nakashima and Renliang Xu. Characterization of Polystyrene Latex Surfaces by Conductometric Titration,Rhodamine 6G Adsorption and Electrophoresis Measurements. Langmuir, 2000, 16(22): 8546-8548. Yong-Kuan Gong, Tsuyoshi Miyamoto, Kenichi Nakashima and Shuichi Hashimoto. Photoinduced Electron Transfer from 3-(9-Anthracence)propyl Ammonium Bromide and Pyrene to Methl viologen on the Surface of Polystyrene Latex Particles. J. Phys. Chem. B, 2000, 104(24): 5772-5778.