个人简介

A native of Germany, Prof. Dieter Söll earned undergraduate and Ph.D. degrees from Technische Hochschule in Stuttgart, Germany. He did postdoctoral work at the University of Wisconsin's Institute for Enzyme Research and served as an assistant professor there 1965-1967. He joined the Yale faculty as an associate professor in MB&B in 1967, was promoted to a full professorship in the department in 1976 and became a professor in the Department of Molecular, Cellular and Developmental Biology and the Department of Chemistry in 1985 and 1995, respectively. He was chair of MB&B 1982-1984. Söll's honors include a 1988 Humboldt Preis (Senior Distinguished Scientist Award). He was named a Humboldt Fellow in 2000. He is a fellow of the American Association for the Advancement of Science and the American Academy of Microbiology, and is a member of the National Academy of Sciences, and the Connecticut Academy of Science and Engineering. He has served on the editorial boards of numerous scientific journals and has been a member of many federal advisory panels and committees responsible for the examination of issues related to genetic research. The editor of nine books and author of over 560 scientific articles, Söll spearheaded international efforts in the 1980s to adopt a common computer database and format for recording masses of genetic information gleaned in the worldwide initiative to decipher the entire human genome. He undertook this effort while serving as chair of the International Advisory Committee for DNA Sequence Databases. Earlier in his career, he helped draw national attention to the dangers of genetic engineering research, particularly experiments using hybrid molecules. His and other scientists' concerns ultimately led to federal guidelines for genetic research. PhD Stuttgart Technical University (1962) Postdoctoral Fellow University of Wisconsin, Madison, WI

研究领域

Organic Chemistry/Biophysical Chemistry

Amino Acyl-tRNA Synthetases; Biochemistry; Biophysics; Genetic Code; Genomics; Organisms

近期论文

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Catalytic complex of human SepSecS-tRNASec reveals mechanism of selenocysteine formation Palioura, S., Sherrer, R.L., Steitz. T.A., Söll, D. and Simonovic, M. (2009) Catalytic complex of human SepSecS-tRNASec reveals mechanism of selenocysteine formation. Science 325, 321-325. A unique cytidine deaminase edits C-to-U in transfer RNAs in archaea Randau, L., Stanley, B.J., Kohlway, A., Mechta, S., Xiong, Y. and Söll, D. (2009) A unique cytidine deaminase edits C-to-U in transfer RNAs in archaea. Science 324, 657-659. Pyrrolysyl-tRNA synthetase–tRNAPyl structure reveals the molecular basis of orthogonality Nozawa, K., O’Donoghue, P., Gundllapalli, S., Araiso, Y., Ishitani, R., Umehara, T., Söll, D. and Nureki, O. (2009) Pyrrolysyl-tRNA synthetase–tRNAPyl structure reveals the molecular basis of orthogonality. Nature 457, 1163-1167. Life without RNase Randau, L., Schröder, I. and Söll, D. (2008) Life without RNase P. Nature 453, 120-123. Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import Rubio, M.A.T., Rinehart, J., Krett, B., Duvezin-Caubet, S., Reichert, A.S., Söll, D. and Alfonzo, J.D. (2008) Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import. Proc. Natl. Acad. Sci. USA 105, 9186-9191. Quality control despite mistranslation caused by an ambiguous genetic code. Ruan, B., Palioura, S., Sabina, J., Marvin-Guy, L., Kochhar, S., LaRossa, R. and Söll, D. (2008) Quality control despite mistranslation caused by an ambiguous genetic code. Proc. Natl. Acad. Sci. USA 105, 16502-16507. Mukai T, Crnković A, Umehara T, Ivanova NN, Kyrpides NC, Söll D: RNA-Dependent Cysteine Biosynthesis in Bacteria and Archaea. MBio. 2017 May 9; 2017 May 9. PMID: 28487430 Reynolds NM, Vargas-Rodriguez O, Söll D, Crnković A: The central role of tRNA in genetic code expansion. Biochim Biophys Acta. 2017 Mar 18; 2017 Mar 18. PMID: 28323071 Mukai T, Vargas-Rodriguez O, Englert M, Tripp HJ, Ivanova NN, Rubin EM, Kyrpides NC, Söll D: Transfer RNAs with novel cloverleaf structures. Nucleic Acids Res. 2017 Mar 17. PMID: 28076288 Englert M, Vargas-Rodriguez O, Reynolds NM, Wang YS, Söll D, Umehara T: A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair. Biochim Biophys Acta. 2017 Mar 10; 2017 Mar 10. PMID: 28288813 Mukai T, Reynolds NM, Crnković A, Söll D: Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria. Life (Basel). 2017 Feb 21; 2017 Feb 21. PMID: 28230768 Yang A, Ha S, Ahn J, Kim R, Kim S, Lee Y, Kim J, Söll D, Lee HY, Park HS: A chemical biology route to site-specific authentic protein modifications. Science. 2016 Nov 4; 2016 Sep 29. PMID: 27708052 Liu Y, Vinyard DJ, Reesbeck ME, Suzuki T, Manakongtreecheep K, Holland PL, Brudvig GW, Söll D: A [3Fe-4S] cluster is required for tRNA thiolation in archaea and eukaryotes. Proc Natl Acad Sci U S A. 2016 Oct 24; 2016 Oct 24. PMID: 27791189 Dobosz-Bartoszek M, Pinkerton MH, Otwinowski Z, Chakravarthy S, Söll D, Copeland PR, Simonović M: Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nat Commun. 2016 Oct 6; 2016 Oct 6. PMID: 27708257 Napolitano MG, Landon M, Gregg CJ, Lajoie MJ, Govindarajan L, Mosberg JA, Kuznetsov G, Goodman DB, Vargas-Rodriguez O, Isaacs FJ, Söll D, Church GM: Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli. Proc Natl Acad Sci U S A. 2016 Sep 20; 2016 Sep 6. PMID: 27601680 Fan C, Ip K, Söll D: Expanding the genetic code of Escherichia coli with phosphotyrosine. FEBS Lett. 2016 Sep; 2016 Aug 11. PMID: 27477338 Melnikov SV, Söll D, Steitz TA, Polikanov YS: Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res. 2016 Jun 2; 2016 Apr 13. PMID: 27079977 Crnković A, Suzuki T, Söll D, Reynolds NM: Pyrrolysyl-tRNA synthetase, an aminoacyl-tRNA synthetase for genetic code expansion. Croat Chem Acta. 2016 Jun; 2016 Jun 14. PMID: 28239189 Melo Czekster C, Robertson WE, Walker AS, Söll D, Schepartz A: In Vivo Biosynthesis of a β-Amino Acid-Containing Protein. J Am Chem Soc. 2016 Apr 27; 2016 Apr 18. PMID: 27086674