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有机合成、催化与不对称反应研究。具体研究内容包括:发展新型的手性有机分子催化剂、手性过渡金属配合物以及手性离子对型催化剂;设计和发现高活性和高对映选择性的有机反应体系;发展绿色、环境友好的不对称催化反应体系;合成具有工业应用价值和具有生物活性的靶向分子。

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Efficient synthesis of optically active 4-nitro-cyclohexanones via bifunctional thiourea-base catalyzed double-Michael addition of nitromethane to dienones, B. Wu, G.-G. Liu, M.-Q. Li, Y. Zhang, S.-Y. Zhang, J.-R. Qiu, X.-P. Xu, S.-J. Ji* and X.-W. Wang* Chem. Commun., 2011, 47, 3992–3994. DOI: 10.1039/C0CC05418F. Dinuclear Zinc Catalyzed Asymmetric Friedel-Crafts Amidoalkylation of Indoles with Aryl Aldimines, B.-L. Wang, N.-K. Li, J.-X. Zhang, G.-G. Liu, T. Liu, Q. Shen*, and X.-W. Wang*,Org. Biomol. Chem. 2011, 9, 2614–2617. DOI: 10.1039/c0ob01200a. Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone,Y.-B. Lan, H. Zhao, Z.-M. Liu, G.-G. Liu, J.-C. Tao* and X.-W. Wang* Org. Lett. 2011, 13, 4866–4869; DOI: 10.1021/ol201943g. Asymmetric Nitroaldol Reactions of Nitroalkanes with Isatins Catalyzed byBifunctional Cinchona Alkaloid Derivatives, M.-Q. Li, J.-X. Zhang, X.-F. Huang, B. Wu, Z.-M. Liu, J. Chen, X.-D. Li, and X.-W. Wang*, Eur. J. Org. Chem. 2011, 5237–5241; DOI: 10.1002/ejoc.201100824. Catalytic Asymmetric Epoxidation of Cyclic Enone,X. W. Wang, C. M. Reisinger, B. List*, J. Am. Chem. Soc. 2008, 130, 6070–6071. Asymmetric Counteranion Directed Catalysis for the Epoxidation of Enals, X. W. Wang, B. List*, Angew. Chem. Int. Ed. 2008, 47, 1119–1122. Catalytic Asymmetric Hydroperoxidation of a,b-Unsaturated Ketones: An Approach to Enantiopure Peroxyhemiketals, Epoxides, and Aldols, C. M. Reisinger, X. W. Wang, B. List*, Angew. Chem. Int. Ed. 2008, 47, 8112–8115. Engineering a Polymeric Chiral Catalyst by using hydrogen and Coordination Interactions, L. Shi, X. W. Wang, C. A. Sandoval, M.X. Li, Q. Y. Qi, Z. T. Li, K. L. Ding*, Angew. Chem. Int. Ed. 2006, 45, 4108–4112. Heterogenization of Shibasaki’s Binol/La Catalyst for Enantioselective Epoxidation of a,b-Unsaturated Ketones with Multitopic Binol Ligands: the Impact of Bridging Spacers, X. W. Wang, L. Shi, M. X. Li, and K. L. Ding*, Angew. Chem. Int. Ed. 2005, 44, 6362–6366. Self-Supported Heterogeneous Catalysts for Enantioselective Hydrogenation, X. W. Wang, K. L. Ding*, J. Am. Chem. Soc. 2004, 126, 10524–10525.

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