Dai, Mingji - Purdue University - Department of Chemistry

个人简介

2021-present: University Faculty Scholar and Showalter Faculty Scholar, Purdue University 2020-present: Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2018-2020: Associate Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2012-2018: Assistant Professor, Department of Chemistry and Center for Cancer Research, Purdue University 2020-present: Chair of Organic Division, Department of Chemistry, Purdue University 2020-present: Program Co-Leader, the Purdue Center for Cancer Research 2019-present: Associate Director, the Purdue Drug Discovery NIH T32 Training Program Member of 2012-present: Center for Cancer Research, Purdue University 2013-present: Institute for Drug Discovery, Purdue University 2013-present: Purdue University Interdisciplinary Life Science Program (PULSe) 2016-present: The Purdue Institute of Inflammation, Immunology, and Infectious Diseases (PI4D) Education and Training 1998-2002: B.S. Peking University, Advisor: Professors Zhen Yang and Jiahua Chen 2002-2004: Research Assistant, Peking University, Advisor: Professors Zhen Yang and Jiahua Chen 2004-2009: Ph.D. in Chemistry, Columbia University, Advisor: Professor Samuel J. Danishefsky 2009-2012: Postdoctoral Fellow, Advisor: Professor Stuart L. Schreiber, Harvard University and The Broad Institute

研究领域

We work on both natural and unnatural molecules with particular potential for the treatment of cancer, CNS disorders and infectious diseases. We view the completion of a synthesis as the beginning of a larger and deeper scholarly inquiry. It would enable us to profile the biology of the selected natural products and rationally designed small molecules, decipher their mechanism of actions, and optimize the lead compounds into biological probe and novel therapeutics development. We also use our new synthetic methodologies to create novel, diverse, complex and bio-functional small-molecule libraries in order to target new disease targets, particularly those important, but “undruggable” ones, such as protein-protein interactions and transcription factors. Total Synthesis via Catalytic Carbonylation Total Synthesis and Biological Study of Polycyclic Diterpenes Divergent Total Synthesis via Funtional Group Pairing Strategy (Hydroxy)Cyclopropanol Ring-Opening Chemistry Amphoteric Diamination to N-Heterocycles Medicinal Chemistry and Chemical Biology

近期论文

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Ma, D.;^ Martin, B. S.;^ Gallagher S. K. (UG); Saito, T. (UG); Dai, M.* “One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine.” J. Am. Chem. Soc. 2021, ASAP. (^These authors contributed equally.) Wang, Y.-C.;^ Cui, C.;^ Dai, M.* Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A. Angew. Chem. Int. Ed. 2021, accepted article (DOI: 10.1002/anie.202109625). (^These authors contributed equally.) Negi, V.; Yang, J.; Speyer, G.; Pulgarin, A.; Handen, A.; Zhao, J.; Tai, Y. Y.; Tang, Y.; Culley, M. K.; Yu, Q.; Forsythe, P.; Gorelova, A.; Watson, A. M.; Aaraj, Y. A.; Satoh, T.; Sharifi-Sanjani, M.; Rajaratnam, A.; Sembrat, J.; Provencher, S.; Yin, X.; Vargas, S. O.; Rojas, M.; Bonnet, S.; Torrino, S.; Wagner, B. K.; Schreiber, S. L.; Dai, M.; Bertero, T.; Ghouleh, I. A.; Kim, S.; Chan, S. Y.* “Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension”. Science Advances, 2021, accepted. Pal, R.; Dai, M.; Seleem, M. N.* “High-throughput screening identifies a novel natural product-inspired molecule inhibiting Clostridioides difficile in vitro and in vivo”. Sci. Rep. 2021, 11, 10913. Cui, C.;^ Dwyer, B. G.;^ Liu, C.; Abegg, D.; Cai, Z.; Hoch, D.; Yin, X.; Qiu, N.; Liu, J.; Adibekian, A.;* Dai, M.* "Total Synthesis and Target Identification of the Curcusone Diterpenes ". J. Am. Chem. Soc. 2021, 143, asap. (^These authors contributed equally.) Raffa, N.; Won, T. H.; Sukowaty A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.; Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* "Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity" Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118. Liang, W.; Cai, X.; Dai, M.* "Cu-Catalyzed Hydroxycyclopropanol Ring-Opening Cyclization to Tetrahydrofurans and Tetrahydropyrans: Short Total Syntheses of Hyperiones" Chem. Sci. 2021, 12, 1311. Cai, X.; Liang, W.; Liu, M. (UG); Li, X. (UG); Dai, M.* "Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones" J. Am. Chem. Soc. 2020, 142, 13677-13682. Kyei-Baffour, K.; Davis, D. C.; Boskovic, Z.; Kato, N.;* Dai, M.* "Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug resistant parasites" Bioorg. Med. Chem. 2020, 28, article 115678. Yin, X.; Ma, K.; Dong, Y. (UG); Dai, M.* "Pyrrole Strategy to the γ-Lactam-Containing Stemona Alkaloids: (±)-Stemoamide, (±)-Tuberostemoamide, and (±)-Sessilifoliamide A" Org. Lett. 2020, 22, 5001-5004. Peery, R.; Kyei-Baffour, K.; Dong, Z.; de Andrade Horn, P.; Dai, M.;* Liu, J.;* Zhang, J.* “Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation” J. Med. Chem. 2020, 63, 7243-7251. Jiang, B.; Dai, M.* “Synthetic Studies towards the Hamigerans with a 6-7-5 Tricyclic Core” Org. Lett. 2020, 22, 4176-4179. Huang, L.; Li, X.; Zhang, W.; Ung, N.; Liu, N.; Yin, X.; Li, Y.; Mcewan, R. E.; Dilkes, B.; Dai, M.; Hicks, G. R.; Raikhel, N. V.; Staiger, C. J. Zhang, C.* “Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibitor Cellulose Biosynthesis” Plant Cell, 2020, 32, 2141-2157 (accepted as a breakthrough report). Oleson, A.; Zhu, T.; Dunn, I.; Bialas, D.; Bai, Y.; Zhang, W.; Dai, M.; Reichman, D.; Tempelaar, R.; Huang, L.; Spano, F.* “Perylene Diimide- Based Hj- and hJ-Aggregates: The Prospect of Exciton Band Shape Engineering in Organic Materials” J. Phys. Chem. C 2019, 123, 20567-20578. Huang, L.; Li, X.; Li, Y.; Yin, X.; Li, Y.; Wu, B.; Mo, H.; Liao, C.; Mengiste, T.; Guo, W.; Dai, M.; Zhang, C.* “Endosidin2-14 targets the exocyst complex in plants and fungal pathogens to inhibit exocytosis” Plant Physiology 2019,180, 1756-1770. Mohammad, H.^; Kyei-Baffour, K.^; Abutaleb, N. S.; Dai, M.*; Seleem, M.* "An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection" J. Glob. Antimicrob. Resist. 2019, 1-7 (doi:10.1016/j.jgar.2019.04.016). (^These authors contributed equally.) Kyei-Baffour, K.^; Mohammad, H.^; Seleem, M.*; Dai, M.* "Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus" Bioorg. Med. Chem. 2019, 27, 1845-1854. (^These authors contributed equally.) Luo, Y.; Yin, X.; Dai, M.* "Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation" J. Antibiotics 2019, 72, 482-485. (Special Issue dedicated to Professor Samuel J. Danishefsky) Cai, X.; Liang, W.; Dai, M.* "Total Syntheses via Cyclopropanols" Tetrahedron 2019, 75, 193-208. (Invited Special Issue Paper: Recent Applications of Metal Catalysis in Natural Product Synthesis. Guest Editors: Jeremy May and John Wood) Davis, D. C.^; Hoch, D. G.^; Wu, L.; Abegg, D.; Martin, B. S. Zhang, Z.-Y.*; Adibekian, A.*; Dai, M.* "Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids" J. Am. Chem. Soc. 2018, 140, 17465-17473. (^These authors contributed equally.)