个人简介

Professor in Chemistry and Molecular and Cell Biology, born 1968. B.S. University of Denver (1990); M.S. University of Colorado (1994); Ph.D. Yale University (1997); Damon Runyon-Walter Winchell Postdoctoral Fellow, University of California, Santa Cruz (1998-1999); Associate Member, Whitehead Institute for Biomedical Research and Assistant Professor of Biology, MIT (1999-2001); Searle Scholar (2000-2003); Sloan Research Fellow (2006-2007).

研究领域

Structural Biology, Biophysical Chemistry and Systems Biology – The mechanisms of the regulation of human translation, bacterial protein synthesis, and fungal growth on plant biomass are being probed by cryo-EM, x-ray crystallography, biophysical chemistry, genomics, proteomics, and enzymology.

Structural Biology, Biophysical Chemistry and Systems Biology – The mechanisms of the regulation of human translation, bacterial protein synthesis, and fungal growth on plant biomass are being probed by cryo-EM, x-ray crystallography, biophysical chemistry, genomics, proteomics, and enzymology.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH. PLoS Biol. 2017 Mar 21;15(3):e2001882. doi: 10.1371/journal.pbio.2001882. eCollection 2017 Mar. Monolayer-crystal streptavidin support films provide an internal standard of cryo-EM image quality. Han BG, Watson Z, Cate JH, Glaeser RM. J Struct Biol. 2017 Mar 1. pii: S1047-8477(17)30032-1. doi: 10.1016/j.jsb.2017.02.009. [Epub ahead of print] Human eIF3: from 'blobology' to biological insight. Cate JH. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160176. doi: 10.1098/rstb.2016.0176. Review. Quantitative determination of ribosome nascent chain stability. Samelson AJ, Jensen MK, Soto RA, Cate JH, Marqusee S. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13402-13407. Epub 2016 Nov 7. Internalization of Heterologous Sugar Transporters by Endogenous α-Arrestins in the Yeast Saccharomyces cerevisiae. Sen A, Acosta-Sampson L, Alvaro CG, Ahn JS, Cate JH, Thorner J. Appl Environ Microbiol. 2016 Nov 21;82(24):7074-7085. Print 2016 Dec 15. Relief of Xylose Binding to Cellobiose Phosphorylase by a Single Distal Mutation. Chomvong K, Lin E, Blaisse M, Gillespie AE, Cate JH. ACS Synth Biol. 2017 Feb 17;6(2):206-210. doi: 10.1021/acssynbio.6b00211. Epub 2016 Oct 3. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA. Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Lee AS, Kranzusch PJ, Doudna JA, Cate JH. Nature. 2016 Aug 4;536(7614):96-9. Epub 2016 Jul 27. Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate JH, Ferguson AD. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93. doi: 10.1073/pnas.1605127113. Epub 2016 Jul 5. Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose. Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JH. PLoS One. 2016 Jun 23;11(6):e0158111. doi: 10.1371/journal.pone.0158111. eCollection 2016. CRISPR-Cas9 Genome Engineering in Saccharomyces cerevisiae Cells. Ryan OW, Poddar S, Cate JH. Cold Spring Harb Protoc. 2016 Jun 1;2016(6):pdb.prot086827. doi: 10.1101/pdb.prot086827. Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion. Smith MD, Arake-Tacca L, Nitido A, Montabana E, Park A, Cate JH. Structure. 2016 Jun 7;24(6):886-96. doi: 10.1016/j.str.2016.02.024. Epub 2016 May 19. STRUCTURE. A Big Bang in spliceosome structural biology. Cate JH. Science. 2016 Mar 25;351(6280):1390-2. doi: 10.1126/science.aaf4465. No abstract available. Editorial overview: Energy biotechnology. Cate JH, Ball AS. Curr Opin Biotechnol. 2016 Apr;38:v-vii. doi: 10.1016/j.copbio.2016.02.019. Epub 2016 Mar 7. No abstract available. Energy biotechnology in the CRISPR-Cas9 era. Estrela R, Cate JH. Curr Opin Biotechnol. 2016 Apr;38:79-84. doi: 10.1016/j.copbio.2016.01.005. Epub 2016 Feb 10. Review. Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation. Thakor N, Smith MD, Roberts L, Faye MD, Patel H, Wieden HJ, Cate JH, Holcik M. RNA Biol. 2016 Feb 1:1-15. doi: 10.1080/15476286.2015.1137419. [Epub ahead of print] Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae. Li X, Park A, Estrela R, Kim SR, Jin YS, Cate JH. Biotechnol Rep (Amst). 2016 Jan 22;9:53-56. doi: 10.1016/j.btre.2016.01.003. eCollection 2016 Mar. Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens. Glaeser RM, Han BG, Csencsits R, Killilea A, Pulk A, Cate JH. Biophys J. 2016 Feb 23;110(4):749-55. doi: 10.1016/j.bpj.2015.07.050. Epub 2015 Sep 17. Review. Cellobionic acid utilization: from Neurospora crassa to Saccharomyces cerevisiae. Li X, Chomvong K, Yu VY, Liang JM, Lin Y, Cate JH. Biotechnol Biofuels. 2015 Aug 16;8:120. doi: 10.1186/s13068-015-0303-2. eCollection 2015. Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Cate JH, Blanchard SC. Nat Commun. 2015 Jul 30;6:7896. doi: 10.1038/ncomms8896.