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Synthesis, antioxidant and antibacterial activities of quinoline incorporated 2,4,5trisubstituted imidazole derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 B Somashekara, G R Vijayakumar
A series of quinoline incorporated 2,4,5-trisubstituted imidazole derivatives (4a-h and 5a-f) have been synthesized. The structures of the synthesized compounds have been established by FT-IR, 1H NMR and mass spectral analysis. The prepared compounds have been evaluated for their in vitro antioxidant activity by DPPH method and antibacterial activity against Bacillus subtilis, Escherichia coli, Bacillus
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Ultrasound mediated synthesis of aldimines from non-enolizable aldehydes at room temperature Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 Dipankar Paula, Gitumoni Kalitaa, Hridoy Jyoti Boraa, Suman Samaib, Paresh Nath Chatterjee
user-friendly, energy efficient method of synthesizing N-sulfonyl aldimines at room temperature (25‒28°C) from readily available and inexpensive reagents has been developed. The method employs ultrasonication from common laboratory ultrasonic cleaner to mediate the reaction. FeCl3 as catalyst and molecular sieves as water scavenger have produced excellent yields of aldimines with short reaction time
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Benzothiazole derivatives of thiazole/ oxazole as potent antimicrobial agents Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 Gajendra Kumar
Non-steroid biologically active heterocyclic compounds (Z)-N'-(4-(2-(4-chlorophenyl)benzo[d]thiazol-3(2H)-yl) oxazol-2yl)-N-(4-substituted phenylimino)-3-substituted-2,3-dihydrobenzo[d]oxazole-2-carboxamidine (4a-4h) and (Z)-N'- (4-(2- (4-chlorophenyl)benzo[d]thiazol-3(2H)-yl)thiazol-2-yl)-N- (4-substituted phenylimino) -3-substituted-2-hydrobenzo[d] thiazole-2-carboxamidine (4a’-4h’) have been synthesized
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Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 A Yardily, M Fathima Shahana, Jino Johnson, Shijula Lindry, T F Abbs Fen Reji
A series of novel (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone compounds have been synthesized. They have been characterized by elemental analysis, IR, 1H and 13C NMR and mass spectral techniques. All the synthesized compounds have been screened for their antibacterial potential and show significant antibacterial activity. Among these (4-amino-2-(4-chlorophenyl)
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Synthesis, crystal structure and fluorescence spectrum of some new 1,2,3-triazolxanthen-3-one derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 Hong-Ru Dong, Chi-Qiong Jin, Zi-Bao Chen
Some new compounds 9-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-6-hydroxy-3H-xanthen-3-one 7a-j have been synthesized for new fluorescence probe material. Their fluorescence and ultraviolet-visible spectra have been studied. Their structures are established by MS, IR and 1H NMR spectral data. The structure of title compound 7c has been identified by X-ray diffraction. C22H14C1N3O3, belongs to triclinic
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Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 Mohammad Arshad, Md Amjad Beg, Abdul R Bhat, Fareeda Athar
Anovel sequence of 1,3,4-oxadiazoline derivatives has been synthesized with an endeavour to explore their consequence on in vitro growth of microbes causing the microbial contagion. In vitro antimicrobial activity has been performed against the Escherichia coli (E. coli) and Proteus mirabilis (P. mirabilis) which are Gram-negative (Gram-ve) and Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis
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Crystal structure determination, molecular modeling and surface analysis studies of 2-(4,6-dihydropyren-3-yl)-1H-benzodimidazole Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 R Manickam, R Jagan, G Jagadeesan, G Srinivasan
Benzoimidazole compound has been synthesized and structurally characterized by single crystal X-ray diffraction studies, molecular docking and Hirshfeld surface analysis. The title compound C23 H14 N2 crystallizes in the Orthorhombic crystal system with the crystallographic space group of Pna21 with cell parameters a = 9.4472(5)Å, b=9.0556(5)Å, c=18.3755(11)Å, V=1572.03(15)Å3 and Z=4. The structure
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Benzothiazole analogues and their biological aspects: A Review Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-12-15 Jyoti V Popli, Manoj R Kumbhare, Ajay R Surana, Mrunal R Bhalerao, Pranay A Agrawal
Heterocyclic compounds analogues have attracted strong interest in medicinal chemistry due to their pharmacological properties. Benzothiazole belongs to the heterocyclic class of bicyclic compounds. It is a combination of two rings six membered and five membered and both the rings are responsible for the therapeutic activity. Different methods are used to synthesize benzothiazole compounds and have
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Spiro-heterocycles: A convenient synthesis and antimicrobial activity of some 3-(5-aryl/aryloxymethyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1',2-thiazolidin-4-ones Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Kahkashan Begum, Akeel Ahmad, Shailendra Tiwari
A new series of novel 3-(5-aryl/aryloxy methyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1'2-thiazolidin-4-ones have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration
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One-pot synthesis of spiro-3,4-dihydro-2H-pyrroles through tandem nucleophilic cyclisation reaction Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Nandkishor Chandan
A very simple and convenient one-pot synthesis of spiro-3,4-dihydro-2H-pyrrole has been developed while synthesising the 2,2,5-trisubstituted pyrrolidines. Initially, the Meldrum’s acid has been treated with ,-unsaturated ketones in presence of anhydrous carbonate base and phase transfer catalyst benzyltriethylammonium chloride in acetonitrile to afford the Michael adduct which is readily converted
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A review on synthesis and biological activity of Schiff Bases Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Deepjyoti Dutta, Nayan Kamal Bhattacharyya, Joydeep Biswas
Schiff bases are versatile organic compounds, gaining importance day by day due to their wide applications. Schiff bases, containing imines or azomethine functional groups, are prepared by condensation of primary amines with carbonyl compounds or they may occur naturally in plants. They have lots of importance in industry and show numerous biological activities including antibacterial, antifungal,
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Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 G Mallikarjun, A Krishnam Raju, J S Yadav
A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1H and 13C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d, 12g and 12l demonstrate promising antimicrobial activity against all the tested
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Synthesis, antimicrobial activity and cytotoxicity of 2-substituted benzimidazole incorporated with thiazole Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Chirag R Fultariya, Jalpa P Harsora
Two new series 2-(2-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylidene)hydrazinyl)-4-(aryl)thiazoles 3a-k and 2-(2-(1- (1-methyl-1H-benzo[d]imidazol-2-yl)ethyl)hydrazinyl)-4-(aryl)thiazoles 4a-k encompassing benzimidazole incorporated with thiazole have been synthesized using rational approach. These thiazole derivatives 3a-k have been reduced at the site of formation of Schiff base (>CH=N−) to obtain
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Derivatization and biological activity studies of 3-chloro-3-chlorosulfenyl spiro tetrahydropyran/tetrahydrothiopyran-4,2'-chroman-4'-one Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Mohamed I Hegab, Hala E M Tolan, Eman M H Morsy, Abdelsalam I S, Alaa M Saleh, Farouk A Gad, Farouk M E Abdel-Megeid
The adducts 4a,b-7a,b have been obtained either by reducing α-chloro-β-oxosulfenyl chlorides 2a,b with iodide ion in the presence of dienes namely, 2-methyl-1,3-butadiene (isoperene), 2,3-dimethyl-1,3-butadiene, 1,2,3,4- tetrachlorocyclopentadiene, or 1,3-cyclohexadiene, respectively; or by thermolysis of oxadithiin derivatives 3a,b in the presence of the same aforementioned dienes presumably via the
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Synthesis, characterization and biological evaluation of some 2-arylbenzoxazole acetic acid derivatives as potential anticancer agents Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Jamal Abdellatif Jilani, Qais Ibrahim Abualassal, Areej Mashhour Assaf, Reham Mahmoud Abu Shmies
A series of 2-arylbenzoxazole compounds possessing a cytotoxic activity as potential anticancer agents has been synthesised. Oxidative coupling of benzaldehyde with o-aminophenol utilizing lead tetraacetate approach has been used to realize the synthesis of compounds 1-11. The cytotoxicity of 1-11 have been screened against breast cancer cell line MCF-7 and human colon cancer cell line HCT-116 utilizing
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Production and identification of intricate bioactive oligosaccharides from Nyctanthesarbor-tristis leaves by a combination of enzymatic, HPAEC and MALDI-TOF-MS techniques Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-11-16 Imran Ali, Shuvam Mukherjee, Subrata Jana, Sadhana Khawas, Bimalendu Ray, Sayani Ray
Non-digestible oligosaccharides are associated with positive health outcomes; however, hemicellulosic oligosaccharides of N. arbor-tristis have not been studied. Herein, we report production of hemicellulosic oligosaccharides from its leaves and their identification. A series of complex neutral oligosaccharides (1-16), produced by endo-(1,4)--D-glucanase digestion of the alkali extracted xyloglucan
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A convenient metal free approach towards the synthesis of dihydropyrimidones mediated by achiral nicotinic acid without solvent Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 Mohinuddin Khan Imon, Koteswara R Kamma, M N Islam, Harendra N Roy
A very simple arrangement of Biginelli’s condensation reaction of 1,3-dicarbonyl compound, aromatic / aliphatic aldehyde and urea / thiourea has been performed in a convenient way by using nicotinic acid without any solvent and under ambient conditions. This approach of pyrimidone synthesis is simple, versatile, metal-free, high yielding and environmentally benign.
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Ultrasonicated synthesis of some potent antimicrobial aryl sulphonamides Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 S Dineshkumar, I Muthuvel, P Mayavel, R Markanadan, V Usha, G Thirunarayanan
Nine N-(2,4-difluorophenyl) substituted benzene sulphonamides have been synthesized by ultrasonication method within short reaction time having more than 90% yield. These sulphonamides have been analyzed by spectral and analytical techniques. The higher yields of sulphonamides have been found to be in case of ultrasonication process as compared to microwave and conventional heating methods. The antimicrobial
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Synthesis and biological evaluation of azetidinone derivatives with pyrazolone moiety Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 Falguni Bhabhor, Harish Dabhi
A Schiff base has been prepared by the reaction of 4-acetyl-5-methyl-2-(4-methylphenyl)-2,4-dihydro-3H-pyrazole-3-one with different substituted amines. Treatment of this Schiff base with chlorobactyl chloride affords the corresponding azetidinone in good yield. All the new compounds have been characterized by IR, 1H NMR, GC-MS and elemental analysis. The antibacterial activity of these compounds has
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Insight QSDAR models for prediction of anticancer activity on Hela cell line of new flavonoid isolating from rhizome Zingiber zerumbet SM in Viet Nam Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 Bui Thi Phuong Thuy, Nguyen Minh Quang, Nguyen Hung Huy, Pham Van Tat
This research predicts the anticancer activity on the Hela cell line of new flavonoid kaempferol-3-O-methyl ether isolating from rhizome Zingiber zerumbet SM by using the spectrum data activity relationship (QSDAR) models. This model has been developed for a set of 3-aminoflavonoids based on the simulated-spectral data 13C NMR and 15O NMR resulting from the semi-empirical quantum chemical calculations
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An efficient solvent-free synthesis of pyrido[2,3-d]pyrimidine derivatives utilizing lactic acid as green and eco-friendly catalyst Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 Mohyeddin Safarzaei, Ebrahim Mollashahi, Mojtaba Lashkari, Malek Taher Maghsoodlou, Nourallah Hazeri
An efficient, solvent-free and one-pot procedure for the synthesis of pyrido[2,3-d]pyrimidine derivatives by condensation of aromatic aldehydes, malononitrile and 6-amino-1,3-dimethyl uracil at 90°C catalyzed by lactic acid as an inexpensive, biological and eco-friendly compound is described. The remarkable benefits of this procedure are green and environmentally friendly reaction conditions, high
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Tomato fruit extract: an environmentally benign catalytic medium for the synthesis of isoxazoles derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 Bhushan B Popatkar, Ankita A Mane, Gangadhar A Meshram
One-pot multicomponent reaction between aromatic aldehyde, hydroxylamine hydrochloride and ethyl acetoacetate/ methyl acetoacetate for the synthesis of isoxazoles derivatives by employing tomato fruit extract as a catalytic medium has been developed. Tomato fruit extract was found to be a favorable catalytic medium for the synthesis of titled compounds. Mild reaction condition, ease of separation,
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An efficient naphthalimide based receptor for selective detection of Hg2+and Pb2+ions # Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 Pramod D Jawale Patil, Sopan M Wagalgave, Mohammad Al Kobaisi, Shailesh S Birajdar, Rajesh S Bhosale, Rajita D Ingle, Rajendra P Pawar, Sheshanath V Bhosale, Sidhanath V Bhosale
Naphthalimide based receptor 1 with N-substituted benzothiazole and pyrrolidine subunit is designed, synthesized, and characterized using FT-IR,1H and 13C NMR spectroscopy and mass spectrometry techniques. The receptor 1 exhibits prominent optical response for Hg2+and Pb2+ions allowing the detection of these ions in acetonitrile (ACN). The formation of the receptor 1:cation complexes have been investigated
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Enantioselective synthesis of bronchodilating agent (R)-Salmeterol # Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-10-20 P L N Ranganath, T Anil, A Venkat Narsaiah
Synthesis of β2-adrenoreceptor agonist bronchodilator (R)-Salmeterol has been described with good yields. The synthesis commenced from commercially available starting materials, 4-hydroxy benzaldehyde and phenylbutanoic acid. The features of the synthetic strategy are Wittig olefination and Sharpless asymmetric dihydroxylation.
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Synthesis and structural confirmation on selective N-alkylation of (Z)-5-((5-chloro- 1H-indol-3-yl)methylene)thiazolidine-2,4-dione analogues with their molecular docking studies Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Vasappanavara Sreenatha, Karnam Jayarampillai Rajendra Prasad
In the present investigation, a series of novel (Z)-5-((5-chloro-1H-indol-3-yl)methylene)thiazolidine-2,4-dione analogues have been designed and synthesized in good yields with the objective of selective N-alkylation at thiazolidine 2,4-dione ring in competence with indole ring under basic conditions in the presence of aprotic solvent dimethylformamide (DMF). The newly synthesized compounds have been
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Synthesis of bis chalcones and transformation into bis heterocyclic compounds with expected antimicrobial activity Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Amira A Ghoneim, Rehab M Elbargisy, Afaf Manoer
One-pot synthesis of novel derivatives of bis-chalcones has been achieved by condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gives compounds 4a,b. This, when reacted with ethyl cyanoacetate in presence of ammonium acetate gives the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a
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An efficient synthesis of 1, 4- disubstituted-3-methyl pyrazolo [4, 3-e]-pyrido [1, 2-a] pyrimidines via Michael addition and cycloelimination reactions Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Shailendra Tiwari, Akeel Ahamd
A new series of novel 1, 4-disubstituted-3-methyl pyrazolo [4,3-e]-pyrido [1,2-a] pyrimidines have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MBC) and minimum fungicidal concentration (MFC) have been determined
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Synthesis and screening for antioxidant and cytotoxic activities of novel 2-thioxo-benzo[f]chromeno[2,3-d]pyrimidin-4-ones derived by cetylpyridinium chloride catalyzed multicomponent reactions in aqueous micellar media Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Dini Ahanthem, Medhabati Thiyam, Reena Haobam, Warjeet S Laitonjam
The cetylpyridinium chloride (CPC) has been used as micellar catalyst in three-component one-pot reaction involving thiobarbituric acids, aromatic aldehydes and β-napthol for synthesizing the novel 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivatives in aqueous media. These 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivativeshave been screened for antioxidant and cytotoxic activities
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Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Medhabati Thiyam, Ranjana Devi Thaodem, Warjeet Singh Laitonjam
A facile and highly efficient one pot multi-component reaction for the synthesis of 2-thio-5-arylbenzo [4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one derivatives 4 under aqueous medium has been developed. The reaction takes place by condensation of thiobarbituric acids 1, 2-aminobenzothiazole 2 and aldehydes 3 using metal-proline catalyzed domino Knoevenagel, Michael and intramolecular cyclization approach
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Preparation, characterization, antibacterial, antifungal and antioxidant activities of novel pyrazole-thiazole derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Purvesh J Shah
In the present study, 4-((1H-benzo[d][1,2,3]triazol-1-yl)methylamino)-N-(2,3-diphenyl-5-aryl-3,3a-dihydro-2H-pyrazolo [3,4-d]thiazol-6(5H)-yl)benzamide IVa-h has been synthesized by reaction between various 4-((1H-benzo[d][1,2,3]triazol- 1-yl) methylamino)-N-(5-arylidene-4-oxo-2-phenylthiazolidin-3-yl)benzamides IIa-h with phenyl hydrazine. The reaction of 4-((1H-benzo[d][1,2,3]triazol-1-yl)methyl
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Synthesis, molecular docking and biological evaluation of new quinoline analogues as potent anti-breast cancer and antibacterial agents Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Shrimant V Rathod, Kailas W Shinde, Prashant S Kharkar, Chetan P Shah, K Aruna, Darshana A Raut
A new class of quinoline analogues have been synthesized from isatin through two steps in good yields. They have been further evaluated for their anticancer activity against a breast cancer cell line (MDA-MB-231) and antibacterial activity against Gram-positive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). All
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Study of solid state structural and bonding features of (E)-1-(4-bromophenyl)-3-(1-H-indol-3-yl)-prop-2-en-1-one Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Anita R Banpurkar, Sachin S Wazalwar, Franc Perdih
Single-crystal study of indolyl chalcone (E)-1-(4-bromophenyl)-3-(1-H-indol-3-yl)-prop-2-en-1-one is reported here. It has been synthesized by microwave assisted method from indole-3-carbaldehyde and 4-bromo acetophenone by Claisen-Schmidt reaction. IR,1H NMR and HRMS data is reported here. The crystalline structure of this compound is described within the sp. gr. I -4; its unit cell parameters are
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Antimicrobial activity of 7,3ʹ,4ʹ-trihydroxyflavonol isolated from Acacia nilotica var. ad stringens Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Al Hafez M Alraih, Mohamed A Mohamed, Mohamed A Alansari, Abu Baker M Osman, Khalda M Ahmed, Ayda Y Abdelrahman, Mohamed E Hamid
Acacia species (Mimosaceae) is widely distributed in tropical and subtropical countries and has a variety of ethnomedicinal uses. There is inadequate laboratory investigation to identify bioactive compounds and therapeutic effect of Acacia nilotica var. ad stringens. This research has been conducted to extract, isolate and identify major compounds from heartwood of Acacia nilotica var. ad stringens
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Designing a new vanillin Schiff base (Z)-4-((2-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one: Synthesis, characterization, crystal structure and biological studies Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Gowri M, Saranya B, Athimoolam S
Novel Schiff base containing antipyrine and o-vanillin has been synthesized and characterized by various physicochemical techniques such as FTIR, UV-Vis, CHN, 1Hand 13C NMR spectral studies. The thermal behavior of the title compound has been examined with Thermogravimetric-Differential thermal analysis (TG-DTA). The structural properties have been further examined by single crystal X-ray diffraction
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Synthesis and biological activity of 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Jayashri D Bhirud, Yogesh B More, Pankaj D Baviskar, Hemant P Narkhede
Incorporation of other hetero-compounds to parent coumarin increases its effectiveness towards its bioactivity. In view of this finding we have synthesized coumarin triazole derivatives. The key synthon used for this reaction pathway are 7-hydroxy-4-methyl-2H-chromen-2-one. This substituted coumarin has been refluxed with 1-bromo-2-chloroethane in presence ofanhydrous K2CO3 to afford 7-(2-chloroet
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Synthesis, characterization and antimicrobial evaluation of some novel (3-methyl- 5-((3-phenylisoxazol-5-yl)methoxy)benzofuran-2-yl)(phenyl)methanones Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 A Kishore Kumar, V Sunitha, P Shankaraiah, P Jalapathi
The synthesis and characterization of a novel class of benzofuran-isoxazole 7a-j hybrid heterocyclic unit are described and their antimicrobial activities evaluated. The antimicrobial investigation studies reveal that the majority of the final target compounds exhibit moderate to excellent activity against tested microbes. Among the compounds screened 7b, 7a and 7i have shown potent activity and compounds
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Biological evaluation of some novel chalcones and their derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 M Thamizhthendral
Chalcones, (E)-N-(4-(4,6-dichloro-1,3,5 –triazin-2-ylamino) phenyl)-3-(4 methoxy-phenyl) acrylamide 4a-c have been prepared by employing Claisen-Schmidt condensation. Further, these chalcones 4a-c on reaction with malononitrile afford cyano-pyridines 5a-c respectively. The constitution of newly synthesised compounds have been characterized on the basis of their IR, 1H and 13C NMR spectral data. These
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An efficient synthesis of Vildagliptin intermediates Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Yufei Li, Lan Jiang, Li Zhang, Jingyu Wang, Peng Xiang, Junyi Pan, Xiangnan Hu
Efficient and high yielding methods for the preparation of vildagliptin 1 intermediate of (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile 2 and 3-amino-1-adamantane alcohol 3 respectively have been described. (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 2 has been synthesized from L-proline 2a via chloroacetyl chloride, performed with acetonitrile in the presence of sulfuric acid via one-pot
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Computational design, synthesis, structural analysis and biological evaluation some novel N-methylated indole incorporating pyrazole moieties Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 J Jani Matilda, T F Abbs Fen Reji
A new method for N-methylation of indoles using methylating reagent dimethyl sulphate has been developed. Structures of the newly synthesized compounds have been established by elemental analysis and spectral data and evaluated as biological activity. The synthesized indoyl pyrazole compounds have been evaluated for their antioxidant and anticancer activities. The obtained results reveal clearly that
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Microwave assisted synthesis of hybrid heterocyclics Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 A Srinivas
Treatment of 2-(2-((3aR,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)-4-oxo-3-phenylthiazolidin-5-yl)acetic acid o-phenyl diamine in conventional and microwave irradiation gives 5-((1H-benzo[d]imidazol-2-yl)methyl)-2-((3aR,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyl tetrahydrofuro[3,4-d][1,3]di
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Modulation of morphology and efficacy of new CB1 receptor antagonist using simple and benign polymeric additives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Kaushik Banerjee, Darshit R Patel, Anchal Kulshrestha, Dhawal Joshipura, Amit Joharapurkar, Krishnarup Ghoshdastidar, Mukul R Jain, Brijesh Kumar Srivastava, Mukut Chakraborty, Sutanuka Pattanayak, Amar Ballabh
The compound 1, [(1H-[1]benzoxepino[5,4-c]pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-4,5-dihydro-N- 1-piperidinyl], a known CB1 modulator has been synthesized and characterized by IR, NMR and single Crystal X-ray study. The single crystal study of 1 displays a number of halogen bonds leading to 1-D network along with other weak noncovalent interactions. The CB1 modulator 1 inherently possesses
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Rational design and expeditious synthesis of aromatic cyanodienone derivatives assisted by cyanide-halide exchange Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Fatemeh Zeraatpisheh, Fatemeh Abadast, Maryam Shahmorad
1-n-Butyl-3-methylimidazolium cyanide ([bmim]CN), in the presence of [bmim]Br has been prepared and used for thefirst time as the medium as well as reagent for the synthesis of aromatic cyanodienones from the corresponding triarylpyrylium perchlorates by cyanide-halide exchange. The [bmim]CN having a reactive anion, is an accelerated reaction technique without external solvent and renders the whole
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Synthesis, characterization and antimicrobial activity of some novel 1-amino dibenzofuran derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 S Syed Shafi
A series of novel 1-amino dibenzo[b,d]furan derivatives have been synthesised via 1,3-dinitrophenol with iodophenol compound. The chemical structures of the compound have been elucidated by 1H and 13C NMR. The mass of the synthesized compounds has been estimated by LCMS. The functional groups present in the title compound are revealed from FT-IR and confirmed by elemental analysis. These compounds
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Synthesis of isomeric naphthofuranyl coumarins as anti-inflammatory and analgesic agents Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Naazneen Yaragatti, Netravati Khanapurmath, Manohar V Kulkarni
A two-step synthetic scheme has been employed for the synthesis of 4-naphtho [2, 1-b] furan-2-yl-chromen-2-ones/4-(3-alkoxy-naphtho-[2,3-b]furan-2-yl)-chromen-2-ones(angular/linear naphthofuranyl coumarins). The reactions have been monitored by TLC and structures of the intermediates and the target compounds have been ascertained by IR, NMR and mass spectral data. Both the isomeric naphthofuranyl coumarins
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Synthesis, DFT calculations, NBO analysis and docking studies of 3-(2-arylamino-4-aminothiazol-5-oyl)pyridine derivatives Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 S Mahil Rani, J Jani Matilda, T F Abbs Fen Reji
Electronic structure of 3-(2-arylamino-4-aminothiazol-5-oyl)pyridine derivatives are investigated theoretically using B3LYB/6-31G (d,p) method. The energy gap between HOMO-LUMO and several thermodynamic properties in the ground state are calculated by means of B3LYP hybrid density functional theory (DFT) method together with 6-31G basis sets. A series of pyridinyl thiazoles were synthesized and characterized
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Design and synthesis of new quinoline hybrid derivatives and their antimicrobial, antimalarial and antitubercular activities Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Mohit Lagdhir, Chintan Pandya, Aditee Pandya, Rajesh H Vekariya, Dhanji P Rajani
All the molecules have been designed on the basis of previously reported active pharmacophores via molecular hybridization. A convenient protocol for the preparation of N-((2-(piperazin-1-yl) quinolin-3-yl)methyl)aniline derivatives via mutli-step synthesis has been described. Spectral analysis using Mass, 1H and 13C NMR spectral techniques have been studied in order to confirm the structure of synthesized
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Synthesis of N-aminoimidazol-2-thione derivatives using tandem approach Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Rashmi Pundeer, Vishwas Chaudhri
The work discussed in the manuscript highlights iodine (III) mediated synthesis of 1-amino-1H-imidazol-2-thione derivatives in a single vessel by tethering tosyloxylation, thiocyanation and heterocyclization reactions. The one pot procedure provides an efficient and clean synthesis of the cyclic title compounds starting from open chain precursors. All the compounds are fully characterized by means
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Montmorillonite K-10 supported palladium nanoparticles: A catalyst for the preparation of α-aminoynones employing copper free acyl Sonogashira reaction Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-09-29 Roopesh Kumar L, Nanda H Alavandimat, Vommina V Sureshbabu
Palladium nanoparticles supported by Montmorillonite K-10 (MMT K-10) are utilized for the synthesis of α-amino ynones using amino acid chlorides and a mild base at room temperature. All the compounds were obtained in good yields. Furthermore, the catalyst is also utilized for the deprotection of protecting groups operating in peptide chemistry.
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Synthesis, characterization, cytotoxicity evaluation and physicochemical properties of some novel N4-substituted aminobenzenesulfonamides Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Mustafa Durgun, Gulay Zengin, Huseyin Zengin, Ismail Koyuncu, Seda Turkoglu, Hasan Sonmez, Ali Kuru
Several N4-substituted aminobenzenesulfonamides derivatives have been synthesized and structural analyses have been carried out using FT-IR, UV-Vis, 1H and 13C NMR, LC-MS-MS and elemental analyses. Photoluminescence and physicochemical properties have also been conducted. Two 4-aminobenzenesulfonamides have been treated with 2-bromopropionyl bromide in pyridine to give their respective bromo substituted
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Design, synthesis and antibacterial activity of 9-aryl-6-(2-naphthyl) [1,2,4]triazolo[4,3-a][1,8]naphthyridines Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Pradeep Kumar Challa, Jagadeesh Kumar Ega, Kavitha Siddoju
A concise and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-naphthyl)[1,2,4] triazolo[4,3-a][1,8]naphthyridines8 by the oxidation of the corresponding aryl aldehyde1-[3-(2-naphthyl) [1,8]naphthyridin- 2-yl]hydrazones 7 using silica gel supported ferric chloride (SiO2-FeCl3) in solvent-free conditions under microwave irradiation. The desired products are obtained in
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Ice-templated fabrication of porous imidazole based polymers for CO2 adsorption Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 P M Nandanwar, R M Jugade
Poly-n-vinyl imidazole and its low-cost derivatives have been synthesized using ice-templation method and the synthesized porous organic polymeric material has been employed for CO2 capture at room temperature. Simple modification of the monomer introducing –OH and –NH2 groups followed by polymerization lead to two new polymers. All the three polymers have been characterized thoroughly using NMR and
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Analogues designing for dephosphorylation of acetylcholinesterase enzyme Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Nidhi Darmwal, B K Singh, Bhanwar S Choudhary, Brajesh Sankar, Nithya Shanti
Organophosphate (OP) causes phosphorylation of acetylcholinesterase enzyme which leads to accumulation of acetylcholine. This phosphorylation generally occurs due to exposure of nerve agents and intake of pesticides, etc. Various standard drugs specifically oxime derivatives (HI-6, Obidoxime, 2-PAM, etc.) are used as AChE enzyme reactivation agents. These standard drugs show least penetration to CNS
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Rational design and expeditious synthesis of aromatic cyanodienone derivatives assisted by cyanide-halide exchange Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Fatemeh Zeraatpisheh, Fatemeh Abadast, Maryam Shahmorad
1-n-Butyl-3-methylimidazolium cyanide ([bmim]CN), in the presence of [bmim]Br has been prepared and used for the first time as the medium as well as reagent for the synthesis of aromatic cyanodienones from the corresponding triarylpyrylium perchlorates by cyanide-halide exchange. The [bmim]CN having a reactive anion, accelerated reaction technique without external solvent renders the whole synthesis
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Synthesis of new 2,2-dimethyl-2H-chromen derivatives as potential anticancer agents Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Meghna Patel, M N Noolvi, Zinal Patel
The synthesis of some new heterocyclic derivatives comprising imidazothaidiazole, diaryl ketone and chromen as starting compound has been reported. The new series of chromen analogues have been synthesized. The reaction has been monitored by Thin Layer Chromatography (TLC) using suitable mobile phase. The Rf values have been compared and the melting points of derivatives determined. Further, these
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An effective total synthesis of four angiotensin-converting enzymes containing silanediols Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Hoan Quoc Duong, Scott McN Sieburth
Four angiotensin-converting enzymes (ACE) containing silanediols 1 have been synthesized successfully in 8% overall yield in 8 steps from inexpensive starting materials such as diphenyldichlorosilane 5, β-methylallylic alcohol 7 and Ellman sulfinimine 9.
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Ammonium chloride catalyzed Knoevenagel condensation in PEG-400 as ecofriendly solvent Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-07-20 Smita R Waghmare
A simple and selective green methodology has been successfully developed for Knoevenagel condensation in polyethylene glycol-400 using 10 mol % ammonium chloride as catalyst. The method is applicable to a wide range of aromatic, heteroaromatic and α,β-unsaturated aldehydes. The reactions have been found to be clean and free from the formation of the Michael adduct.
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Design, synthesis and evaluation of new colourimetric chemosensors containing quinazolinones moiety for some cations detection in an aqueous medium and biological sample Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-06-25 Ayman M Algohary, Mohamed M Hassan, Sami G Almalkic, Esam S Al-Malkid
The current project deals with designing and synthesizing of colourimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives have been synthesized via reaction of the novel 6-nitro-2-propyl-4H-benzo[d][1,3]oxazin-4-one 3 with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine
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Design, synthesis of novel pyrazolopyridine derivatives and CREBBP bromodomain inhibitors docking and molecular dynamics Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-06-25 M Saamanthi, S Aruna, R Girija, D Vinod
A sequence of novel compounds pyrazolopyridine have been prepared by a general synthetic method. Due to high efficiency and selectivity, anticancer agents consisting of combined molecules have gained great interests. The IC50 values have been determined against cell line U937, the results obtained indicate the potential effects against cancer cell line. The cell potency of cell line is best for compounds
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Synthesis and biological evaluation of a series of novel benzofuran-2-carboxylate 1,2,3-triazoles Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-06-25 K Bhaskar, J S Yadav
A facile and efficient synthetic route has been developed to substituted benzofuran-2-carboxylate 1,2,3-triazoles for the first time by reacting prop-2-yn-1-yl benzofuran-2-carboxylate with a variety of substituted aryl/benzyl azides in DMF/H2O system employing standard click reaction. This new method has the lead of good yields, inexpensive reagents, easily available, easy work-up, mild reaction conditions
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Efficient and region-selective conversion of octanes to epoxides under ambient conditions: Performance of tri-copper catalyst, [Cu3I(L)]+1 (L=7-N-Etppz) Indian J. Chem. Sect. B (IF 0.456) Pub Date : 2021-06-25 Penumaka Nagababu, Perala Sudheer Paul, Thatiparthi Byragi Reddy, Reddithota J Krupadam
In this paper, is described the conversion of the octane group of hydrocarbons into industrially important epoxides using tri-copper catalyst, [Cu3I(L)]+1 (L=7-N-Etppz). The role of hydrogen peroxide as a sacrificial oxygen donor during catalytic conversion to epoxides has been investigated. The performance of the catalyst has been evaluated in terms of turnover numbers (TON) and turnover frequencies