The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6]uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl⁻ and HCO₃⁻ efficiently. Remarkably, rates for Cl⁻/NO₃⁻ exchange are two orders of magnitude lower. The higher rates of Cl⁻/HCO₃⁻ transport can be explained by the ability of the bambusurils to complex Cl⁻ and HCO₃⁻ simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO₃⁻ appear to contribute to the poor Cl⁻/NO₃⁻ exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl⁻/HCO₃⁻ exchange.

跨脂质双层的氯化物和碳酸氢盐的交换是重要的生物学过程。合成分子可以充当这些阴离子的移动载体，尽管大多数分子几乎没有选择性。在这里，我们三个bambus [6]脲大环与氟化苄基，其能够交换氯功能化的报告^-和HCO ₃ ^-高效。值得注意的是，对氯率^- / NO ₃ ^-交换是两个数量级低。氯的高利率^- / HCO ₃ ^-运输可以通过bambusurils的复杂氯的能力解释^-和HCO ₃ ^-同时，促进它们在双层界面上的交换。此外，这些系统对NO的异常高的亲和力和选择性₃ ^-似乎有助于穷人氯^- / NO ₃ ^-交换。这项工作不仅彰显的阴离子结合特性在阴离子运输的重要性，但也bambusurils为考虑氯观察到的高率阴离子传输应用的潜在关联^- / HCO ₃ ^-交换。