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Stretchable Low‐Impedance Nanocomposite Comprised of Ag–Au Core–Shell Nanowires and Pt Black for Epicardial Recording and Stimulation
Advanced Materials Technologies ( IF 6.8 ) Pub Date : 2019-12-18 , DOI: 10.1002/admt.201900768
Sung‐Hyuk Sunwoo 1, 2 , Sang Ihn Han 1, 2 , Hyejeong Kang 3 , Ye Seul Cho 3 , Dongjun Jung 1, 2 , Chanhyuk Lim 1, 2 , Chaehong Lim 1, 2 , Myung‐jin Cha 3 , Seung‐Pyo Lee 3 , Taeghwan Hyeon 1, 2 , Dae‐Hyeong Kim 1, 2
Affiliation  

Cardiac resynchronization therapy (CRT) presents effective means to modulate cardiac conduction and related functions in heart failure patients. However, the conventional CRT delivers electric current at only two points on the heart, therefore, it is unable to provide comprehensive electrical support to the heart. Additionally, the CRT‐device structure faces several issues, such as those associated with the endocardial screw tip, which may cause myocardial degeneration, and the metal lead wire, which may lead to intravascular thrombosis and lead infection. Moreover, the conventional CRT has limitations in mechanically improving the cardiac contractility, which often cannot prevent further ventricular dilation. Here, a fabrication of an elastoconductive epicardial mesh using a stretchable low‐impedance nanocomposite comprising Ag–Au core–shell nanowires and platinum black (Pt black) in elastomer to provide a potential solution to the above‐mentioned clinical issues is reported. The proposed nanocomposite structure exhibits high stretchability, conductivity, and biocompatibility in combination with low impedance. These features facilitate the realization of high signal‐to‐noise ratios in electrocardiogram recordings, and high‐quality electrical stimulations. The proposed epicardial mesh is implanted on the surface of an animal heart with minimum traumatic stress, and is consequently able to conduct high‐quality cardiac recording and electrical stimulation in rodents.

中文翻译:

可伸缩的低阻抗纳米复合材料,由Ag-Au核-壳纳米线和Pt黑色组成,用于心外膜记录和刺激

心脏再同步疗法(CRT)为调节心力衰竭患者的心脏传导和相关功能提供了有效的手段。然而,常规的CRT仅在心脏的两个点上传送电流,因此,它不能为心脏提供全面的电支持。此外,CRT设备的结构还面临一些问题,例如与心内膜螺钉尖端相关的问题(可能导致心肌变性)以及金属导线(可能导致血管内血栓形成和铅感染)。而且,常规的CRT在机械地改善心脏收缩性方面具有局限性,这通常不能防止进一步的心室扩张。这里,据报道,使用可伸展的低阻抗纳米复合材料制造的弹性心外膜网片,该复合材料包含Ag-Au核-壳纳米线和弹性体中的铂黑(Pt黑),可以为上述临床问题提供潜在的解决方案。所提出的纳米复合材料结构具有高拉伸性,导电性和生物相容性,并具有低阻抗。这些功能有助于在心电图记录中实现高信噪比以及高质量的电刺激。拟议的心外膜网片以最小的创伤应力植入动物心脏的表面,因此能够在啮齿动物中进行高质量的心脏记录和电刺激。
更新日期:2020-03-09
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