Fenton reaction–based chemodynamic therapy (CDT) has attracted considerable attention for tumor treatment, because the Fenton reaction can degrade endogenous H₂O₂ within the tumor to form reactive oxygen species (ROS) to kill cancer cells. The kinetics of the Fenton reaction has significantly influenced its treatment efficacy. It is crucial to enhance the reaction kinetics at the maximum H₂O₂ concentration to quickly produce vast amounts of ROS to achieve treatment efficacy, which to date, has not been realized. Herein, reported is an efficacious CDT treatment of breast cancer using biomimetic CS‐GOD@CM nanocatalysts, which are rationally designed to significantly boost the Fenton reaction through improvement of H₂O₂ concentration within tumors, and application of the second near‐infrared (NIR‐II) light irradiation at the maximum concentration, which is monitored by photoacoustic imaging. The biomimetic nanocatalysts are composed of ultra‐small Cu_2−xSe (CS) nanoparticles, glucose oxidase (GOD), and tumor cell membrane (CM). The nanocatalysts can be retained in tumor for more than two days to oxidize glucose and produce an approximately 2.6‐fold increase in H₂O₂ to enhance the Fenton reaction under the NIR‐II irradiation. This work demonstrates for the first time the CDT treatment of cancer enhanced by the NIR‐II light.

中文翻译：

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通过通用仿生Fenton纳米催化剂和第二次近红外光辐照增强反应动力学，促进H2O2指导的癌症化学动力学治疗。

基于Fenton反应的化学动力学疗法（CDT）已引起肿瘤治疗的广泛关注，因为Fenton反应可降解肿瘤中的内源性H ₂ O ₂形成活性氧（ROS），从而杀死癌细胞。Fenton反应的动力学极大地影响了其治疗效果。至关重要的是在最大H ₂ O ₂浓度下增强反应动力学，以快速产生大量的ROS，以达到迄今为止尚未实现的治疗功效。本文报道了使用仿生CS‐GOD @ CM纳米催化剂对乳腺癌进行有效CDT治疗的方法，该纳米催化剂经过合理设计，可通过改善H ₂来显着促进Fenton反应肿瘤内的O ₂浓度，并以最大浓度施加第二次近红外（NIR-II）光照射，这通过光声成像进行监控。仿生纳米催化剂由超小型Cu ₂ - _x Se（CS）纳米颗粒，葡萄糖氧化酶（GOD）和肿瘤细胞膜（CM）组成。纳米催化剂可以在肿瘤中保留两天以上，以氧化葡萄糖并增加H ₂ O ₂约2.6倍，从而在NIR-II辐射下增强Fenton反应。这项工作首次证明了通过NIR-II光增强的CDT治疗癌症。