Towards clinical application of tissue engineering for erectile penile regeneration.,Nature Reviews Urology

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Towards clinical application of tissue engineering for erectile penile regeneration.
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2019-10-24 , DOI: 10.1038/s41585-019-0246-7
Tom W Andrew ₁ , Muholan Kanapathy ₁ , Log Murugesan ₁ , Asif Muneer ₂ , Deepak Kalaskar ₁ , Anthony Atala ₃

Affiliation

Penile wounds after traumatic and surgical amputation require reconstruction in the form of autologous tissue transfers. However, currently used techniques are associated with high infection rates, implant erosion and donor site morbidity. The use of tissue-engineered neocorpora provides an alternative treatment option. Contemporary tissue-engineering strategies enable the seeding of a biomaterial scaffold and subsequent implantation to construct a neocorpus. Tissue engineering of penile tissue should focus on two main strategies: first, correcting the volume deficit for structural integrity in order to enable urinary voiding in the standing position and second, achieving erectile function for sexual activity. The functional outcomes of the neocorpus can be addressed by optimizing the use of stem cells and scaffolds, or alternatively, the use of gene therapy. Current research in penile tissue engineering is largely restricted to rodent and rabbit models, but the use of larger animal models should be considered as a better representation of the anatomical and physiological function in humans. The development of a cell-seeded scaffold to achieve and maintain erection continues to be a considerable challenge in humans. However, advances in penile tissue engineering show great promise and, in combination with gene therapy and surgical techniques, have the potential to substantially improve patient outcomes.

中文翻译：

组织工程在阴茎勃起再生中的临床应用。

创伤性和手术截肢后的阴茎伤口需要以自体组织移植的形式进行重建。然而，目前使用的技术与高感染率、植入物侵蚀和供区发病率有关。组织工程neocorpora的使用提供了另一种治疗选择。当代组织工程策略使生物材料支架的播种和随后的植入能够构建新语料库。阴茎组织的组织工程应侧重于两个主要策略：首先，纠正结构完整性的体积不足，以便在站立位置进行排尿；其次，实现性活动的勃起功能。新语料库的功能结果可以通过优化干细胞和支架的使用来解决，或者，基因疗法的使用。目前对阴茎组织工程的研究主要局限于啮齿动物和兔子模型，但应考虑使用更大的动物模型来更好地代表人类的解剖和生理功能。开发用于实现和维持勃起的细胞种子支架对人类来说仍然是一个相当大的挑战。然而，阴茎组织工程的进步显示出巨大的希望，并且与基因治疗和手术技术相结合，有可能显着改善患者的预后。开发用于实现和维持勃起的细胞种子支架对人类来说仍然是一个相当大的挑战。然而，阴茎组织工程的进步显示出巨大的希望，并且与基因治疗和手术技术相结合，有可能显着改善患者的预后。开发用于实现和维持勃起的细胞种子支架对人类来说仍然是一个相当大的挑战。然而，阴茎组织工程的进步显示出巨大的希望，并且与基因治疗和手术技术相结合，有可能显着改善患者的预后。

更新日期：2019-10-25

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