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Prenatal alcohol exposure and facial morphology in a UK cohort
Drug and Alcohol Dependence ( IF 4.2 ) Pub Date : 2019-02-05 , DOI: 10.1016/j.drugalcdep.2018.11.031
Laurence J. Howe , Gemma C. Sharp , Gibran Hemani , Luisa Zuccolo , Stephen Richmond , Sarah J. Lewis

Background

High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.

Methods

In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption.

Results

In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero.

Conclusions

There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.



中文翻译:

英国队列中的产前酒精暴露和面部形态

背景

众所周知,高水平的产前酒精暴露会导致一系列不良后果,包括胎儿酒精综合症(FAS);但是,中低度暴露的影响的特征不太明确。先前的发现表明正常范围的面部形态差异可能是酒精暴露和相关不良反应的标志。

方法

在《雅芳父母和孩子的纵向研究》中,我们使用自我报告调查表和ADH1B rs1229984的母亲基因型作为母亲饮酒的量度,测试了母亲饮酒与后代中六种FAS相关面部表型之间的关联。。

结果

在自我报告的饮酒量(N = 4233)和rs1229984基因型(N = 3139)的分析中,我们均未发现有强有力的统计证据表明孕妇饮酒量与面部测试表型之间存在关联。效果估计的方向与重度酒精暴露的已知效果兼容,但置信区间主要集中在零附近。

结论

在代表一般人群的样本中,没有有力的证据表明产前饮酒对面部形态正常范围变化的影响。

更新日期:2019-02-05
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