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Quantum sensing of microRNAs with nitrogen-vacancy centers in diamond Commun. Chem. (IF 5.9) Pub Date : 2024-05-06 Justas Zalieckas, Martin M. Greve, Luca Bellucci, Giuseppe Sacco, Verner Håkonsen, Valentina Tozzini, Riccardo Nifosì
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Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries Commun. Chem. (IF 5.9) Pub Date : 2024-05-01 Ryosuke Nagasawa, Kazumitsu Onizuka, Kaoru R. Komatsu, Emi Miyashita, Hirotaka Murase, Kanna Ojima, Shunya Ishikawa, Mamiko Ozawa, Hirohide Saito, Fumi Nagatsugi
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A facile DNA coacervate platform for engineering wetting, engulfment, fusion and transient behavior Commun. Chem. (IF 5.9) Pub Date : 2024-05-01 Wei Liu, Jie Deng, Siyu Song, Soumya Sethi, Andreas Walther
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Challenges for exploiting nanomagnet properties on surfaces Commun. Chem. (IF 5.9) Pub Date : 2024-05-01 Guillem Gabarró-Riera, E. Carolina Sañudo
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Efficient reduction method enables access to rare-earth telluride clusters Commun. Chem. (IF 5.9) Pub Date : 2024-04-29 Chenyu Wang
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A protocol for controlled reactivity shift in the 2,2-difluorovinyl motif used for selective S–18F and C–18F bond formation Commun. Chem. (IF 5.9) Pub Date : 2024-04-29 Mudasir Maqbool, Jimmy Erik Jakobsson, Santosh Reddy Alluri, Vasko Kramer, Patrick Johannes Riss
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Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader Commun. Chem. (IF 5.9) Pub Date : 2024-04-29 Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier
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Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds Commun. Chem. (IF 5.9) Pub Date : 2024-04-27 Hongjian Qin, Zijian Han, Emmanuel Mintah Bonku, Haiguo Sun, Abdullajon Odilov, Fuqiang Zhu, Safomuddin Abduahadi, Weiliang Zhu, Jingshan Shen, Haji A. Aisa
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Synthesis, characterisation, and catalytic application of a soluble molecular carrier of sodium hydride activated by a substituted 4-(dimethylamino)pyridine Commun. Chem. (IF 5.9) Pub Date : 2024-04-27 Peter A. Macdonald, Alan R. Kennedy, Catherine E. Weetman, Stuart D. Robertson, Robert E. Mulvey
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Borates expand their reduction power Commun. Chem. (IF 5.9) Pub Date : 2024-04-25 Johannes Kreutzer
The chemical reduction of group 1 metal cations to their zero-valent species is challenging. Now, a bipyridine-stabilized borate anion joins the ranks of suitable reducing agents and also proves active in the two-electron reduction of CO2.
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Regulation of enzymatic reactions by chemical composition of peptide biomolecular condensates Commun. Chem. (IF 5.9) Pub Date : 2024-04-20 Rif Harris, Shirel Veretnik, Simran Dewan, Avigail Baruch Leshem, Ayala Lampel
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A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein stabilizers to treat Gaucher disease Commun. Chem. (IF 5.9) Pub Date : 2024-04-20 Huang-Yi Li, Wei-An Chen, Hung-Yi Lin, Chi-Wei Tsai, Yu-Ting Chiu, Wen-Yi Yun, Ni-Chung Lee, Yin-Hsiu Chien, Wuh-Liang Hwu, Wei-Chieh Cheng
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Combinatorial biosynthesis for the engineering of novel fungal natural products Commun. Chem. (IF 5.9) Pub Date : 2024-04-18 Elizabeth Skellam, Sanjeevan Rajendran, Lei Li
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Multi-step FRET systems based on discrete supramolecular assemblies Commun. Chem. (IF 5.9) Pub Date : 2024-04-18 Dengli Chen, Tangxin Xiao, Éric Monflier, Leyong Wang
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Design of a recombinant asparaginyl ligase for site-specific modification using efficient recognition and nucleophile motifs Commun. Chem. (IF 5.9) Pub Date : 2024-04-18 Jiabao Tang, Mengling Hao, Junxian Liu, Yaling Chen, Gulimire Wufuer, Jie Zhu, Xuejie Zhang, Tingquan Zheng, Mujin Fang, Shiyin Zhang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia
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Transaminase-catalysis to produce trans-4-substituted cyclohexane-1-amines including a key intermediate towards cariprazine Commun. Chem. (IF 5.9) Pub Date : 2024-04-18 Emese Farkas, Péter Sátorhelyi, Zoltán Szakács, Miklós Dékány, Dorottya Vaskó, Gábor Hornyánszky, László Poppe, János Éles
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Fast and effective molecular property prediction with transferability map Commun. Chem. (IF 5.9) Pub Date : 2024-04-17 Shaolun Yao, Jie Song, Lingxiang Jia, Lechao Cheng, Zipeng Zhong, Mingli Song, Zunlei Feng
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Predicting permeation of compounds across the outer membrane of P. aeruginosa using molecular descriptors Commun. Chem. (IF 5.9) Pub Date : 2024-04-12 Pedro D. Manrique, Inga V. Leus, César A. López, Jitender Mehla, Giuliano Malloci, Silvia Gervasoni, Attilio V. Vargiu, Rama K. Kinthada, Liam Herndon, Nicolas W. Hengartner, John K. Walker, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya, S. Gnanakaran
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An experimentally representative in-silico protocol for dynamical studies of lyophilised and weakly hydrated amorphous proteins Commun. Chem. (IF 5.9) Pub Date : 2024-04-12 Elisa Bassotti, Sara Gabrielli, Gaio Paradossi, Ester Chiessi, Mark Telling
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Chasing weakly-bound biological water in aqueous environment near the peptide backbone by ultrafast 2D infrared spectroscopy Commun. Chem. (IF 5.9) Pub Date : 2024-04-11 Juan Zhao, Pengyun Yu, Tiantian Dong, Yanzhou Wu, Fan Yang, Jianping Wang
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Functionalizing tandem mass tags for streamlining click-based quantitative chemoproteomics Commun. Chem. (IF 5.9) Pub Date : 2024-04-10 Nikolas R. Burton, Keriann M. Backus
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An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin Commun. Chem. (IF 5.9) Pub Date : 2024-04-10 Jake A. Hill, Yvonne Nyathi, Sam Horrell, David von Stetten, Danny Axford, Robin L. Owen, Godfrey S. Beddard, Arwen R. Pearson, Helen M. Ginn, Briony A. Yorke
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Self-assembly of stabilized droplets from liquid–liquid phase separation for higher-order structures and functions Commun. Chem. (IF 5.9) Pub Date : 2024-04-09 Mehwish Naz, Lin Zhang, Chong Chen, Shuo Yang, Hongjing Dou, Stephen Mann, Jianwei Li
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Molecular motion of a nanoscopic moonlander via translations and rotations of triphenylphosphine on graphite Commun. Chem. (IF 5.9) Pub Date : 2024-04-06 Anton Tamtögl, Marco Sacchi, Victoria Schwab, Michael M. Koza, Peter Fouquet
Mass transport at surfaces determines the kinetics of processes such as heterogeneous catalysis and thin-film growth, with the diffusivity being controlled by excitation across a translational barrier. Here, we use neutron spectroscopy to follow the nanoscopic motion of triphenylphosphine (P(C6H5)3 or PPh3) adsorbed on exfoliated graphite. Together with force-field molecular dynamics simulations, we
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Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release Commun. Chem. (IF 5.9) Pub Date : 2024-04-06 Benjamin J. Read, John B. O. Mitchell, Rafael G. da Silva
Heavy-isotope substitution into enzymes slows down bond vibrations and may alter transition-state barrier crossing probability if this is coupled to fast protein motions. ATP phosphoribosyltransferase from Acinetobacter baumannii is a multi-protein complex where the regulatory protein HisZ allosterically enhances catalysis by the catalytic protein HisGS. This is accompanied by a shift in rate-limiting
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Enhancing property and activity prediction and interpretation using multiple molecular graph representations with MMGX Commun. Chem. (IF 5.9) Pub Date : 2024-04-05 Apakorn Kengkanna, Masahito Ohue
Graph Neural Networks (GNNs) excel in compound property and activity prediction, but the choice of molecular graph representations significantly influences model learning and interpretation. While atom-level molecular graphs resemble natural topology, they overlook key substructures or functional groups and their interpretation partially aligns with chemical intuition. Recent research suggests alternative
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Cut-insert-stitch editing reaction (CIStER) sequence for surgical chemical glycan editing Commun. Chem. (IF 5.9) Pub Date : 2024-04-02 Sumit Sen, Suman Kundu, Sandip Pasari, Srinivas Hotha
Post-synthetic surgical editing enables synthesizing diverse molecules from a common scaffold. Editing carbohydrates by inserting a foreign glycan is still a far-reaching goal for synthetic chemists. In this study, a one-pot-three-step chemical approach was employed to edit glycoconjugates. It is comprised of three steps: the first is a ‘cut’ step, cleaving one of the interglycosidic bonds and producing
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Soluble individual metal atoms and ultrasmall clusters catalyze key synthetic steps of a natural product synthesis Commun. Chem. (IF 5.9) Pub Date : 2024-04-04 Silvia Rodríguez-Nuévalos, Miguel Espinosa, Antonio Leyva-Pérez
Metal individual atoms and few-atom clusters show extraordinary catalytic properties for a variety of organic reactions, however, their implementation in total synthesis of complex organic molecules is still to be determined. Here we show a 11-step linear synthesis of the natural product (±)-Licarin B, where individual Pd atoms (Pd1) catalyze the direct aerobic oxidation of an alcohol to the carboxylic
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Effects of multi-functional additives during foam extrusion of wheat gluten materials Commun. Chem. (IF 5.9) Pub Date : 2024-04-03 Mercedes A. Bettelli, Qisong Hu, Antonio J. Capezza, Eva Johansson, Richard T. Olsson, Mikael S. Hedenqvist
To broaden the range in structures and properties, and therefore the applicability of sustainable foams based on wheat gluten expanded with ammonium-bicarbonate, we show here how three naturally ocurring multifunctional additives affect their properties. Citric acid yields foams with the lowest density (porosity of ~50%) with mainly closed cells. Gallic acid acts as a radical scavenger, yielding the
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nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale Commun. Chem. (IF 5.9) Pub Date : 2024-04-01 Isabel Nuñez Santiago, Nataliia V. Machushynets, Marija Mladic, Doris A. van Bergeijk, Somayah S. Elsayed, Thomas Hankemeier, Gilles P. van Wezel
Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast majority has not yet been discovered, among others because the hidden chemical space is obscured by previously identified (and typically abundant) antibiotics in culture extracts. Efficient dereplication is therefore key to the discovery of our future medicines. Here we present an analytical platform for
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Theoretical framework for mixed-potential-driven catalysis Commun. Chem. (IF 5.9) Pub Date : 2024-04-01 Mo Yan, Nuning Anugrah Putri Namari, Junji Nakamura, Kotaro Takeyasu
Mixed-potential-driven catalysis is expected to be a distinctive heterogeneous catalytic reaction that produces products different from those produced by thermal catalytic reactions without the application of external energy. Electrochemically, the mechanism is similar to that of corrosion. However, a theory that incorporates catalytic activity as a parameter has not been established. Herein, we report
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Quantification and description of photothermal heating effects in plasmon-assisted electrochemistry Commun. Chem. (IF 5.9) Pub Date : 2024-04-01 Md. Al-Amin, Johann V. Hemmer, Padmanabh B. Joshi, Kimber Fogelman, Andrew J. Wilson
A growing number of reports have demonstrated plasmon-assisted electrochemical reactions, though debate exists around the mechanisms underlying the enhanced activity. Here we address the impact of plasmonic photothermal heating with cyclic voltammetry measurements and finite-element simulations. We find that plasmonic photothermal heating causes a reduction in the hysteresis of the anodic and cathodic
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On the nature of Con±/0 clusters reacting with water and oxygen Commun. Chem. (IF 5.9) Pub Date : 2024-03-30 Lijun Geng, Pengju Wang, Shiquan Lin, Ruili Shi, Jijun Zhao, Zhixun Luo
Bulk cobalt does not react with water at room temperature, but cobalt nanometals could yield corrosion at ambient conditions. Insights into the cobalt cluster reactions with water and oxygen enable us to better understand the interface reactivity of such nanometals. Here we report a comprehensive study on the gas-phase reactions of Con±/0 clusters with water and oxygen. All these Con±/0 clusters were
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Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides Commun. Chem. (IF 5.9) Pub Date : 2024-03-28 Masakazu Kobayashi, Naho Onozawa, Kenichi Matsuda, Toshiyuki Wakimoto
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Computational mechanistic investigation of the kinetic resolution of α-methyl-phenylacetaldehyde by norcoclaurine synthase Commun. Chem. (IF 5.9) Pub Date : 2024-03-27 Shiqing Zhang, Chenghua Zhang, Aijing Guo, Baoyan Liu, Hao Su, Xiang Sheng
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Dynamics of bulk and surface oxide evolution in copper foams for electrochemical CO2 reduction Commun. Chem. (IF 5.9) Pub Date : 2024-03-28 Fan Yang, Shan Jiang, Si Liu, Paul Beyer, Stefan Mebs, Michael Haumann, Christina Roth, Holger Dau
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The reaction mechanism of the Ideonella sakaiensis PETase enzyme Commun. Chem. (IF 5.9) Pub Date : 2024-03-27 Tucker Burgin, Benjamin C. Pollard, Brandon C. Knott, Heather B. Mayes, Michael F. Crowley, John E. McGeehan, Gregg T. Beckham, H. Lee Woodcock
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The rise of data repositories in materials chemistry Commun. Chem. (IF 5.9) Pub Date : 2024-03-22 Konstantin Stracke, Jack D. Evans
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Body odor samples from infants and post-pubertal children differ in their volatile profiles Commun. Chem. (IF 5.9) Pub Date : 2024-03-21 Diana Owsienko, Lisa Goppelt, Katharina Hierl, Laura Schäfer, Ilona Croy, Helene M. Loos
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Self-sustainable autonomous soft actuators Commun. Chem. (IF 5.9) Pub Date : 2024-03-19 Zhen-Zhou Nie, Meng Wang, Hong Yang
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Organomediated polymerization Commun. Chem. (IF 5.9) Pub Date : 2024-03-21 Satoshi Honda, Karin Odelius, Haritz Sardon
Communications Chemistry is pleased to introduce a Collection of articles focused on organomediated polymerization. Here, the Guest Editors highlight the themes within and look towards the future of this research field.
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Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors Commun. Chem. (IF 5.9) Pub Date : 2024-03-21 Stefano Cinti, Stefano Tomassi, Chiara Ciardiello, Rossella Migliorino, Marinella Pirozzi, Alessandra Leone, Elena Di Gennaro, Virginia Campani, Giuseppe De Rosa, Vincenzo Maria D’Amore, Salvatore Di Maro, Greta Donati, Sima Singh, Ada Raucci, Francesco Saverio Di Leva, Horst Kessler, Alfredo Budillon, Luciana Marinelli
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Synergetic binary organocatalyzed ring opening polymerization for the precision synthesis of polysiloxanes Commun. Chem. (IF 5.9) Pub Date : 2024-03-21 Hiroshi Okamoto, Atsushi Sogabe, Satoshi Honda
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Exploiting hot electrons from a plasmon nanohybrid system for the photoelectroreduction of CO2 Commun. Chem. (IF 5.9) Pub Date : 2024-03-20 Ananta Dey, Vitor R. Silveira, Robert Bericat Vadell, Andreas Lindblad, Rebecka Lindblad, Vitalii Shtender, Mikaela Görlin, Jacinto Sá
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Integrated preservation of water activity as key to intensified chemoenzymatic synthesis of bio-based styrene derivatives Commun. Chem. (IF 5.9) Pub Date : 2024-03-14 Philipp Petermeier, Jan Philipp Bittner, Tobias Jonsson, Pablo Domínguez de María, Emil Byström, Selin Kara
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Shape programming of liquid crystal elastomers Commun. Chem. (IF 5.9) Pub Date : 2024-03-14 Andraž Rešetič
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Carbocationoids, a concept for controlling highly reactive cationic species Commun. Chem. (IF 5.9) Pub Date : 2024-03-13 Hikaru Fujita, Daichi Shimada, Jotaro Kudo, Kazuyuki Kosha, Satoshi Kakuyama, Hiromitsu Terasaki, Munetaka Kunishima
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Generic and accurate prediction of retention times in liquid chromatography by post–projection calibration Commun. Chem. (IF 5.9) Pub Date : 2024-03-08 Yan Zhang, Fei Liu, Xiu Qin Li, Yan Gao, Kang Cong Li, Qing He Zhang
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Efficient retrosynthetic planning with MCTS exploration enhanced A* search Commun. Chem. (IF 5.9) Pub Date : 2024-03-07 Dengwei Zhao, Shikui Tu, Lei Xu
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Kinetic control over the chiral-selectivity in the formation of organometallic polymers on a Ag(110) surface Commun. Chem. (IF 5.9) Pub Date : 2024-03-05 R. S. Koen Houtsma, Floris van Nyendaal, Meike Stöhr
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Quantifying mass transport limitations in a microfluidic CO2 electrolyzer with a gas diffusion cathode Commun. Chem. (IF 5.9) Pub Date : 2024-03-05 Venu Gopal Agarwal, Sophia Haussener
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Water-compatible dynamic covalent bonds based on a boroxine structure Commun. Chem. (IF 5.9) Pub Date : 2024-03-02 Virginia Valderrey Berciano
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Sequestration within peptide coacervates improves the fluorescence intensity, kinetics, and limits of detection of dye-based DNA biosensors Commun. Chem. (IF 5.9) Pub Date : 2024-02-29 Christopher M. Green, Deborah Sementa, Divita Mathur, Joseph S. Melinger, Priyasha Deshpande, Shana Elbaum-Garfinkle, Igor L. Medintz, Rein V. Ulijn, Sebastián A. Díaz
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Vinyl thianthrenium-mediated cysteine bioconjugation Commun. Chem. (IF 5.9) Pub Date : 2024-02-27 Huijuan Guo
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Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor Commun. Chem. (IF 5.9) Pub Date : 2024-02-28 Sumire Honda Malca, Nadine Duss, Jasmin Meierhofer, David Patsch, Michael Niklaus, Stefanie Reiter, Steven Paul Hanlon, Dennis Wetzl, Bernd Kuhn, Hans Iding, Rebecca Buller
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A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase Commun. Chem. (IF 5.9) Pub Date : 2024-02-28 Chiung-Wen Mary Chang, Shun-Chang Wang, Chun-Hsiung Wang, Allan H. Pang, Cheng-Han Yang, Yao-Kai Chang, Wen-Jin Wu, Ming-Daw Tsai
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Interactions between the protein barnase and co-solutes studied by NMR Commun. Chem. (IF 5.9) Pub Date : 2024-02-28 Clare R. Trevitt, D. R. Yashwanth Kumar, Nicholas J. Fowler, Mike P. Williamson
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Dual-controlled guest release from coordination cages Commun. Chem. (IF 5.9) Pub Date : 2024-02-27 Yuqing Yao, Chengyuan Shao, Shuwei Wang, Qiufang Gong, Jia Liu, Hua Jiang, Ying Wang
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Stepwise on-surface synthesis of nitrogen-doped porous carbon nanoribbons Commun. Chem. (IF 5.9) Pub Date : 2024-02-24 Jin Xu, Shuaipeng Xing, Jun Hu, Ziliang Shi