Pyroptosis is a highly immunogenic cell death due to the release of damage-associated molecular patterns and pro-inflammatory cytokines such as IL-1β and IL-18. A recent study published in Cell by Wright and colleagues uncovered a novel mechanism in which extracellular vesicles released from pyroptotic cells serve as carriers of functional gasdermin D pores to propagate pyroptosis to bystander cells, providing valuable insights into the process of bystander cell death and opening up potential therapeutic avenues.

中文翻译：

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Gasdermin D 毛孔搭便车：细胞外囊泡传播细胞焦亡

焦亡是一种高度免疫原性的细胞死亡，这是由于损伤相关分子模式和促炎细胞因子（如 IL-1β 和 IL-18）的释放而导致的。 Wright 及其同事最近发表在 《细胞》 上的一项研究揭示了一种新机制，其中从焦亡细胞释放的细胞外囊泡作为功能性 gasdermin D 孔的载体，将细胞焦亡传播到旁观者细胞，为旁观者细胞死亡过程提供了宝贵的见解，并开辟了潜在的治疗途径。