Microreactor is one of the process intensification techniques which uses reaction dimensions below millimeter size and have greater yield within lesser reaction time and a high heat transfer rate due to their high surface to volume ratio. To develop energy efficient reactors, microheater is chosen as the heating source for microreactor which consume less power than the conventional heating elements. Using response surface methodology (RSM) and artificial neural network (ANN) the effects of the biodiesel process variables was analyzed: catalyst concentration (0.5-2.5 wt.%), reaction temperature (35-55°C), flow rate (5-25 mL/min), oil to methanol molar ratio (1:6-1:18), and power supplied to the microheater (15-35 W). To observe more than set limit, Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) and VIKOR were used to evaluate the optimum conditions. Under the optimum conditions of 20 mL/min flow rate, 45°C reaction temperature, 1.5 wt.% catalyst concentration, 1:9 oil to methanol molar ratio, and 20 W power supplied, the maximum biodiesel yield for microreactor with microheater is 91.1%. Using ultrasonic mixing additionally for microreactor with microheater had maximum yield of 94.4% under the optimum conditions.

微反应器是过程强化技术之一，它使用毫米级以下的反应尺寸，在更短的反应时间内具有更高的产率，并且由于其高表面积与体积比而具有高传热速率。为了开发节能反应器，选择微型加热器作为微反应器的加热源，其比传统加热元件消耗更少的功率。使用响应面法 (RSM) 和人工神经网络 (ANN) 分析了生物柴油工艺变量的影响：催化剂浓度 (0.5-2.5 wt.%)、反应温度 (35-55°C)、流量 (5- 25 mL/min），油与甲醇摩尔比（1:6-1:18），以及向微加热器供电（15-35 W）。为了观察超出设定限制的情况，使用与理想解决方案相似的订单性能技术 (TOPSIS) 和 VIKOR 来评估最佳条件。在流量20 mL/min、反应温度45℃、催化剂浓度1.5 wt.%、油甲醇摩尔比1:9、供电功率20 W的最佳条件下，微加热器微反应器的最大生物柴油产率为91.1 %。微加热器微反应器加超声混合，在最佳条件下，收率最高可达94.4%。