Ultrasound-Triggered Cascade Amplification of Nanotherapy,Advanced Materials

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Ultrasound-Triggered Cascade Amplification of Nanotherapy
Advanced Materials ( IF 27.4 ) Pub Date : 2023-05-24 , DOI: 10.1002/adma.202303158
Fan Zhuang _{1,

2} , Huijing Xiang ₃ , Beijian Huang _{1,

2} , Yu Chen ₃

Affiliation

Ultrasound (US)-triggered cascade amplification of nanotherapies has attracted considerable attention as an effective strategy for cancer treatment. With the remarkable advances in materials chemistry and nanotechnology, a large number of well-designed nanosystems have emerged that incorporate presupposed cascade amplification processes and can be activated to trigger therapies such as chemotherapy, immunotherapy, and ferroptosis, under exogenous US stimulation or specific substances generated by US actuation, to maximize antitumor efficacy and minimize detrimental effects. Therefore, summarizing the corresponding nanotherapies and applications based on US-triggered cascade amplification is essential. This review comprehensively summarizes and highlights the recent advances in the design of intelligent modalities, consisting of unique components, distinctive properties, and specific cascade processes. These ingenious strategies confer unparalleled potential to nanotherapies based on ultrasound-triggered cascade amplification and provide superior controllability, thus overcoming the unmet requirements of precision medicine and personalized treatment. Finally, the challenges and prospects of this emerging strategy are discussed and it is expected to encourage more innovative ideas and promote their further development.

中文翻译：

超声触发纳米疗法的级联放大

超声（US）触发的纳米疗法级联放大作为癌症治疗的有效策略引起了广泛关注。随着材料化学和纳米技术的显着进步，出现了大量精心设计的纳米系统，它们结合了预设的级联放大过程，并且可以在外源性US刺激或产生的特定物质下被激活以触发化疗、免疫治疗和铁死亡等治疗由美国驱动，以最大限度地提高抗肿瘤功效并最大限度地减少有害影响。因此，总结基于US触发级联放大的相应纳米疗法和应用是至关重要的。这篇综述全面总结并强调了智能模式设计的最新进展，包括独特的组件、独特的属性和特定的级联过程。这些巧妙的策略赋予基于超声触发级联放大的纳米疗法无与伦比的潜力，并提供卓越的可控性，从而克服精准医疗和个性化治疗未满足的要求。最后，讨论了这一新兴战略的挑战和前景，并期望鼓励更多的创新想法并促进其进一步发展。

更新日期：2023-05-24

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