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Skin-Interfaced Wearable Sweat Sensors for Precision Medicine
Chemical Reviews ( IF 51.4 ) Pub Date : 2023-03-27 , DOI: 10.1021/acs.chemrev.2c00823
Jihong Min 1 , Jiaobing Tu 1 , Changhao Xu 1 , Heather Lukas 1 , Soyoung Shin 1 , Yiran Yang 1 , Samuel A Solomon 1 , Daniel Mukasa 1 , Wei Gao 1
Affiliation  

Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward personalized healthcare. Advances in flexible electronics, materials science, and electrochemistry have spurred the development of wearable sweat sensors that enable the continuous and noninvasive screening of analytes indicative of health status. Existing major challenges in wearable sensors include: improving the sweat extraction and sweat sensing capabilities, improving the form factor of the wearable device for minimal discomfort and reliable measurements when worn, and understanding the clinical value of sweat analytes toward biomarker discovery. This review provides a comprehensive review of wearable sweat sensors and outlines state-of-the-art technologies and research that strive to bridge these gaps. The physiology of sweat, materials, biosensing mechanisms and advances, and approaches for sweat induction and sampling are introduced. Additionally, design considerations for the system-level development of wearable sweat sensing devices, spanning from strategies for prolonged sweat extraction to efficient powering of wearables, are discussed. Furthermore, the applications, data analytics, commercialization efforts, challenges, and prospects of wearable sweat sensors for precision medicine are discussed.

中文翻译:

用于精准医疗的皮肤接口可穿戴汗液传感器

可穿戴传感器在实现个性化健康监测、预测分析和及时干预个性化医疗保健方面具有巨大潜力。柔性电子、材料科学和电化学的进步促进了可穿戴汗液传感器的发展,这些传感器能够对指示健康状况的分析物进行连续、无创的筛查。可穿戴传感器现有的主要挑战包括:提高汗液提取和汗液传感能力,改进可穿戴设备的外形尺寸以尽量减少佩戴时的不适感和可靠的测量,以及了解汗液分析物对发现生物标志物的临床价值。这篇评论对可穿戴汗液传感器进行了全面的回顾,并概述了努力弥合这些差距的最先进的技术和研究。介绍了汗液的生理学、材料、生物传感机制和进展,以及汗液诱导和采样的方法。此外,还讨论了可穿戴汗液传感设备的系统级开发的设计考虑因素,从延长排汗策略到可穿戴设备的高效供电。此外,还讨论了用于精准医疗的可穿戴汗液传感器的应用、数据分析、商业化工作、挑战和前景。
更新日期:2023-03-27
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