Chemical Synthesis of Proteins with Base-Labile Posttranslational Modifications Enabled by a Boc-SPPS Based General Strategy Towards Peptide C-Terminal Salicylaldehyde Esters,Angewandte Chemie International Edition

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Chemical Synthesis of Proteins with Base-Labile Posttranslational Modifications Enabled by a Boc-SPPS Based General Strategy Towards Peptide C-Terminal Salicylaldehyde Esters
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-07 , DOI: 10.1002/anie.202214053
Wenjie Ma ₁ , Hongxiang Wu ₁ , Sha Liu ₁ , Tongyao Wei ₁ , Xiang David Li ₁ , Han Liu ₁ , Xuechen Li ₁

Affiliation

A Boc-SPPS based method towards the synthesis of peptide C-terminal salicylaldehyde esters compatible with all canonical amino acids was developed. The method could facilitate the synthesis of proteins bearing base-labile post-translational modifications, e.g., O-acetylation and S-palmitoylation.

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