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Facile Fabrication of Starch-Based Microrods by Shear-Assisted Antisolvent-Induced Nanoprecipitation and Solidification
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-10-13 , DOI: 10.1021/acsmacrolett.2c00524 Qimeng Zhang 1, 2 , Xiaopeng Pei 1 , Kepeng Hu 3 , Yating Zhou 1 , Ming-Liang Ma 4 , Mingquan Wang 5 , Huiyong An 2 , Ying Tan 1
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-10-13 , DOI: 10.1021/acsmacrolett.2c00524 Qimeng Zhang 1, 2 , Xiaopeng Pei 1 , Kepeng Hu 3 , Yating Zhou 1 , Ming-Liang Ma 4 , Mingquan Wang 5 , Huiyong An 2 , Ying Tan 1
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Rod-like particles have attracted increasing attention because of their unique shape-dependent properties, which enable their superior performance compared to their isotropic counterparts. Thus, rod-like particles have potential applications in many fields, especially in biomedicine. However, the fabrication of uniform rod-like particles is challenging because of the principle of interfacial energy minimization. Herein, we present a facile, rapid, and cost-effective strategy for preparing starch-based microrods with tunable aspect ratios via shear-assisted antisolvent-induced nanoprecipitation and solidification. The preformed spherical particles swollen by the mixed solvent were elongated by the shear force and solidified in rod-like shape by antisolvent induction. The resulting starch-based microrods can encapsulate hydrophobic active substances and be modified with functional groups, indicating their potential applications as drug carriers and biologically active materials. The formation mechanism of the starch-based microrods discovered in this study provides a new perspective on the fabrication of rod-like polymer particles.
中文翻译：
剪切辅助抗溶剂诱导纳米沉淀和凝固法简便制备淀粉基微棒
棒状颗粒因其独特的形状相关特性而受到越来越多的关注，这使得它们与各向同性对应物相比具有更优越的性能。因此，棒状颗粒在许多领域具有潜在的应用，尤其是在生物医学领域。然而，由于界面能最小化原理，均匀棒状颗粒的制备具有挑战性。在此，我们提出了一种简便、快速且具有成本效益的策略，通过剪切辅助抗溶剂诱导的纳米沉淀和凝固制备具有可调纵横比的淀粉基微棒。被混合溶剂溶胀的预制球形颗粒在剪切力作用下被拉长，并在抗溶剂感应作用下固化成棒状。由此产生的淀粉基微棒可以封装疏水活性物质并用官能团进行修饰，表明它们作为药物载体和生物活性材料的潜在应用。本研究发现的淀粉基微棒的形成机制为棒状聚合物颗粒的制备提供了新的视角。
更新日期：2022-10-13
中文翻译：
剪切辅助抗溶剂诱导纳米沉淀和凝固法简便制备淀粉基微棒
棒状颗粒因其独特的形状相关特性而受到越来越多的关注，这使得它们与各向同性对应物相比具有更优越的性能。因此，棒状颗粒在许多领域具有潜在的应用，尤其是在生物医学领域。然而，由于界面能最小化原理，均匀棒状颗粒的制备具有挑战性。在此，我们提出了一种简便、快速且具有成本效益的策略，通过剪切辅助抗溶剂诱导的纳米沉淀和凝固制备具有可调纵横比的淀粉基微棒。被混合溶剂溶胀的预制球形颗粒在剪切力作用下被拉长，并在抗溶剂感应作用下固化成棒状。由此产生的淀粉基微棒可以封装疏水活性物质并用官能团进行修饰，表明它们作为药物载体和生物活性材料的潜在应用。本研究发现的淀粉基微棒的形成机制为棒状聚合物颗粒的制备提供了新的视角。
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