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Assessment of Exercise-Associated Gastrointestinal Perturbations in Research and Practical Settings: Methodological Concerns and Recommendations for Best Practice
International Journal of Sport Nutrition and Exercise Metabolism ( IF 2.5 ) Pub Date : 2022-08-13 , DOI: 10.1123/ijsnem.2022-0048
Ricardo J S Costa 1 , Pascale Young 1 , Samantha K Gill 2 , Rhiannon M J Snipe 3 , Stephanie Gaskell 1 , Isabella Russo 1 , Louise M Burke 4
Affiliation  

Strenuous exercise is synonymous with disturbing gastrointestinal integrity and function, subsequently prompting systemic immune responses and exercise-associated gastrointestinal symptoms, a condition established as “exercise-induced gastrointestinal syndrome.” When exercise stress and aligned exacerbation factors (i.e., extrinsic and intrinsic) are of substantial magnitude, these exercise-associated gastrointestinal perturbations can cause performance decrements and health implications of clinical significance. This potentially explains the exponential growth in exploratory, mechanistic, and interventional research in exercise gastroenterology to understand, accurately measure and interpret, and prevent or attenuate the performance debilitating and health consequences of exercise-induced gastrointestinal syndrome. Considering the recent advancement in exercise gastroenterology research, it has been highlighted that published literature in the area is consistently affected by substantial experimental limitations that may affect the accuracy of translating study outcomes into practical application/s and/or design of future research. This perspective methodological review attempts to highlight these concerns and provides guidance to improve the validity, reliability, and robustness of the next generation of exercise gastroenterology research. These methodological concerns include participant screening and description, exertional and exertional heat stress load, dietary control, hydration status, food and fluid provisions, circadian variation, biological sex differences, comprehensive assessment of established markers of exercise-induced gastrointestinal syndrome, validity of gastrointestinal symptoms assessment tool, and data reporting and presentation. Standardized experimental procedures are needed for the accurate interpretation of research findings, avoiding misinterpreted (e.g., pathological relevance of response magnitude) and overstated conclusions (e.g., clinical and practical relevance of intervention research outcomes), which will support more accurate translation into safe practice guidelines.



中文翻译:

在研究和实际环境中评估与运动相关的胃肠道紊乱:方法学问题和最佳实践建议

剧烈运动是扰乱胃肠道完整性和功能的同义词,随后会引发全身免疫反应和运动相关的胃肠道症状,这种情况被确立为“运动诱发的胃肠道综合征”。当运动压力和相关的恶化因素(即外在的和内在的)相当大时,这些与运动相关的胃肠道扰动会导致表现下降和具有临床意义的健康影响。这可能解释了运动胃肠病学探索性、机械性和介入性研究的指数增长,以了解、准确测量和解释、预防或减轻运动诱发的胃肠道综合征的表现衰弱和健康后果。考虑到运动胃肠病学研究的最新进展,已经强调该领域已发表的文献一直受到大量实验限制的影响,这些限制可能会影响将研究结果转化为实际应用和/或未来研究设计的准确性。这篇前瞻性方法综述试图强调这些问题,并为提高下一代运动胃肠病学研究的有效性、可靠性和稳健性提供指导。这些方法问题包括参与者筛选和描述、劳累和劳累热应激负荷、饮食控制、水合状态、食物和液体供应、昼夜节律变化、生物性别差异、综合评估运动性胃肠道综合征的既定标志物、胃肠道症状评估工具的有效性以及数据报告和呈现。需要标准化的实验程序来准确解释研究结果,避免误解(例如,反应幅度的病理相关性)和夸大结论(例如,干预研究结果的临床和实践相关性),这将支持更准确地转化为安全实践指南.

更新日期:2022-08-13
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