Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and the enrichment of fibroblast populations with a pro-regenerative phenotype. Strain-programmed patches might also be effective for the treatment of other forms of acute and chronic wounds.

糖尿病足溃疡和其他愈合不良的慢性伤口可以用生物工程皮肤或生长因子治疗。然而，大多数患者并没有从这些治疗中获益。在这里，我们报告了应变编程贴片的开发和临床前治疗性能，该贴片可快速牢固地粘附在糖尿病伤口上，并促进伤口闭合和再上皮化。该贴片由结合到预拉伸亲水性弹性体背衬的干燥交联聚合物网络粘合剂层组成，并实施基于水合作用的形状记忆机制，以基于分析和有限元的可编程方式机械收缩糖尿病伤口造型。在小鼠和人类皮肤中，以及在小型猪和人化小鼠中，该贴片通过促进更快的再上皮化和血管生成以及富集具有促再生表型的成纤维细胞群来促进糖尿病伤口的愈合。应变程序贴片也可能对治疗其他形式的急性和慢性伤口有效。