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Redox and Other Biological Activities of Tea Catechins That May Affect Health: Mechanisms and Unresolved Issues
Journal of Agricultural and Food Chemistry ( IF 6.1 ) Pub Date : 2022-06-21 , DOI: 10.1021/acs.jafc.2c02527
Chung S Yang 1 , Tingting Chen 2 , Chi-Tang Ho 3
Affiliation  

The beneficial health effects of green tea have been attributed to tea catechins. However, the molecular mechanisms of action, especially those in vivo, remain unclear. This article reviews the redox and other activities of tea catechins, using (−)-epigallocatechin-3-gallate (EGCG), as an example. EGCG is a well-known antioxidant. However, EGCG can be oxidized to generate reactive oxygen species and EGCG quinone. We propose that EGCG quinone can react with Keap-1 to activate Nrf2-regulated cytoprotective enzymes. Tissue levels of catechins are important for their biological activities; a section is devoted to reviewing the biological fates of tea catechins after ingestion. Possible EGCG oxidation in vivo and whether the oligomeric forms are biologically active in animals are discussed. We also review the effects of EGCG on the activities of enzymes, receptors, and other signaling molecules through binding and raise a question about whether the autoxidation of EGCG in vitro may lead to artifacts or misinterpretation in some studies. Finally, we discuss the challenges in the extrapolation of in vitro results to situations in vivo and the translation of laboratory studies to humans.

中文翻译:

可能影响健康的茶儿茶素的氧化还原和其他生物活性:机制和未解决的问题

绿茶对健康的有益影响归因于茶中的儿茶素。然而,作用的分子机制,尤其是在体内的作用,仍不清楚。本文以 (-)-epigallocatechin-3-gallate (EGCG) 为例,回顾了茶儿茶素的氧化还原和其他活性。EGCG是一种众所周知的抗氧化剂。然而,EGCG 可以被氧化生成活性氧和 EGCG 醌。我们提出EGCG醌可以与Keap-1反应以激活Nrf2调节的细胞保护酶。儿茶素的组织水平对其生物活性很重要;有一节专门回顾茶儿茶素摄入后的生物学命运。讨论了体内可能的 EGCG 氧化以及寡聚形式在动物中是否具有生物活性。我们还回顾了 EGCG 通过结合对酶、受体和其他信号分子活性的影响,并提出了一个问题,即 EGCG 在体外的自氧化是否可能导致一些研究中的伪影或误解。最后,我们讨论了将体外结果外推到体内情况以及将实验室研究转化为人类所面临的挑战。
更新日期:2022-06-21
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